청각 오가노이드 연구 어디까지 진행되었나?

Abstract

The development of auditory organoids represents a groundbreaking advancement in auditoryresearch and regenerative medicine. These three-dimensional tissue structures, derived frompluripotent stem cells, replicate the architecture and function of the human inner ear, includ-ing the key sensory and neural cell types such as hair cells, supporting cells, and neurons. Au-ditory organoids enable researchers to study inner ear development, model genetic hearingdisorders, and evaluate the effects of ototoxic drugs. Recent breakthroughs include the suc-cessful differentiation and functional validation of hair cell-like structures responsive tosound signals, as well as the integration of LGR5+ hair cell progenitor cells to enhance regen-erative capacity. Despite significant progress, there remain many challenges of achieving fullfunctional maturation, improving reproducibility, and scaling production for clinical applica-tions. This emerging technology holds immense potential for understanding the inner ear biol-ogy, advancing personalized medicine, and developing novel therapies for hearing loss andbalance disorders.