두경부 편평세포암에서 Claudin-1 발현의 예후인자적 의미
Prognostic Significance of the Expression of Claudin-1 in Head and Neck Squamous Cell Carcinoma
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Background and Objectives Claudin-1 (CLDN-1) is the major component of tight junctionsand functions in controlling cell to cell adhesion. Certain claudins were expressed aberrantlyand proved to have prognostic significance in various human cancers. However, its clinical significancehas been poorly understood in head and neck squamous cell carcinoma (HNSCC). The aim of this study was to investigate the relationship between CLDN-1 expression and clinicopathologicparameters in HNSCC. Subjects and Method The surgical specimens of primary HNSCCs from a consecutive cohortof 91 patients were retrospectively collected. Immunohistochemical staining for CLDN-1was performed blindly by two pathologists. CLDN-1 staining intensity was scored semi-quantitativelyon a scale of 0 to 3 (0: negative; 1: weak; 2: moderate; 3: strong). For the statistical analysis,the expression levels were classified as low (negative and weak) and high (moderate and strong). Next, the association between CLDN-1 expression and clinicopathological features & clinicaloutcomes was analyzed. Results The increased CLDN-1 expression was significantly associated with lymphatic invasion(p=0.019). The expression level of CLDN-1 was not associated with pathological T stage,lymph node metastasis or recurrence. Kaplan-Meier analysis found that 3-year overall survival(OS) rate was 53% in patients with high level CLDN-1 expression and 74% in patients with lowlevel CLDN-1 expression. It also found that 5-year OS rate was 49% in patients with high levelCLDN-1 expression and 68% in patients with low level CLDN-1 expression. A significantly poorOS rate was recorded in patients with high level of CLDN-1 expression compared to patients withlow level CLDN-1 expression (p=0.022). Conclusion CLDN-1 may serve as useful prognostic marker in patients with HNSCCs.
Abstract
Background and Objectives Claudin-1 (CLDN-1) is the major component of tight junctionsand functions in controlling cell to cell adhesion. Certain claudins were expressed aberrantlyand proved to have prognostic significance in various human cancers. However, its clinical significancehas been poorly understood in head and neck squamous cell carcinoma (HNSCC). The aim of this study was to investigate the relationship between CLDN-1 expression and clinicopathologicparameters in HNSCC. Subjects and Method The surgical specimens of primary HNSCCs from a consecutive cohortof 91 patients were retrospectively collected. Immunohistochemical staining for CLDN-1was performed blindly by two pathologists. CLDN-1 staining intensity was scored semi-quantitativelyon a scale of 0 to 3 (0: negative; 1: weak; 2: moderate; 3: strong). For the statistical analysis,the expression levels were classified as low (negative and weak) and high (moderate and strong). Next, the association between CLDN-1 expression and clinicopathological features & clinicaloutcomes was analyzed. Results The increased CLDN-1 expression was significantly associated with lymphatic invasion(p=0.019). The expression level of CLDN-1 was not associated with pathological T stage,lymph node metastasis or recurrence. Kaplan-Meier analysis found that 3-year overall survival(OS) rate was 53% in patients with high level CLDN-1 expression and 74% in patients with lowlevel CLDN-1 expression. It also found that 5-year OS rate was 49% in patients with high levelCLDN-1 expression and 68% in patients with low level CLDN-1 expression. A significantly poorOS rate was recorded in patients with high level of CLDN-1 expression compared to patients withlow level CLDN-1 expression (p=0.022). Conclusion CLDN-1 may serve as useful prognostic marker in patients with HNSCCs.
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