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돌발성 난청 환자에서 고혈압과 당뇨 유무에 따른 Lipo-Prostaglandin의 치료 효과 비교 연구

A Comparative Study on the Treatment Effect of Lipo-Prostagladin with Hypertension and Diabetes Mellitus in Sudden Sensorineural Hearing Loss Patients

홍성화|서지원|김명구|최철희|허혜정
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2021.08|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제64권 제8호|pp. 540-547|DOI https://doi.org/10.3342/kjorl-hns.2020.01053

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키워드

HypertensionDiabetes mellitusSudden hearing loss.Lipo-PGE1
주제분류이비인후과학

초록

Background and Objectives Several drugs which can improve blood flow have been usedas treatment options for sudden sensorineural hearing loss (SSNHL) based on the theory thatimprovement of perfusion into the inner ear will help restore hearing. Lipo-prostaglandin E1(lipo-PGE1) is a well-known vasodilator that increases peripheral blood flow. The purpose ofthis study was to investigate the effect of lipo-PGE1 on the recovery of the SSNHL patientswith hypertension or diabetes. Subjects and Method We retrospectively analyzed 801 patients who were diagnosed withSSNHL from January 2007 to December 2018. All patients were treated with 48 mg of methylprednisolonefor 5 days; some patients received lipo-PGE1, depending on the attending physician. They were divided into four groups according to the presence or absence of hypertensionand diabetes. Hearing test was performed again one month after treatment and comparedwith the test results at the time of diagnosis. Results As a result of comparing the hearing thresholds before and after the treatment ineach group, there was a significant improvement in hearing thresholds in all groups (p<0.001). However, when comparing the effect of lipo-PGE1 for hearing change, there was a significantdifference only in the group without any underlying diseases (p=0.016). Conclusion In this study, we show that lipo-PGE1 was helpful in hearing recovery whenused in patients without underlying diseases rather than patients with hypertension or diabetes. Further studies will be needed to determine the therapeutic effects of lipo-PGE1 as an adjuvanttreatment in SSNHL patients.

Abstract

Background and Objectives Several drugs which can improve blood flow have been usedas treatment options for sudden sensorineural hearing loss (SSNHL) based on the theory thatimprovement of perfusion into the inner ear will help restore hearing. Lipo-prostaglandin E1(lipo-PGE1) is a well-known vasodilator that increases peripheral blood flow. The purpose ofthis study was to investigate the effect of lipo-PGE1 on the recovery of the SSNHL patientswith hypertension or diabetes. Subjects and Method We retrospectively analyzed 801 patients who were diagnosed withSSNHL from January 2007 to December 2018. All patients were treated with 48 mg of methylprednisolonefor 5 days; some patients received lipo-PGE1, depending on the attending physician. They were divided into four groups according to the presence or absence of hypertensionand diabetes. Hearing test was performed again one month after treatment and comparedwith the test results at the time of diagnosis. Results As a result of comparing the hearing thresholds before and after the treatment ineach group, there was a significant improvement in hearing thresholds in all groups (p<0.001). However, when comparing the effect of lipo-PGE1 for hearing change, there was a significantdifference only in the group without any underlying diseases (p=0.016). Conclusion In this study, we show that lipo-PGE1 was helpful in hearing recovery whenused in patients without underlying diseases rather than patients with hypertension or diabetes. Further studies will be needed to determine the therapeutic effects of lipo-PGE1 as an adjuvanttreatment in SSNHL patients.

참고문헌 (24)

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관련 논문AI추천

Comparative Analysis of the Combined Therapeutic Effects of Lipoprostaglandin E1 on Sudden Idiopathic Sensorineural Hearing Loss김명구, 김준수, 심행선대한청각학회 · Journal of Audiology & Otology2017 · 제21권 제1호돌발성 난청 환자에서 Lipoprostaglandin E1 과 Carbogen 흡입의 병행치료 효과에 관한 연구김명구대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2008 · 제51권 제1호돌발성 난청에서 스테로이드 초치료군과 재치료군의 성적 비교고재범, 권재환, 김창회, 이환호, 조기헌대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2019 · 제62권 제12호Comparison of Intratympanic, Systemic, and Combined Steroid Therapies for Sudden Sensorineural Hearing Loss in Patients with Diabetes Mellitus강현택, 김보경, 김효준, 이세아, 이윤지, 이종대대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2019 · 제62권 제7호심혈관계 위험요인이 돌발성 난청의 회복에 미치는 영향공성호, 박석원, 박주현, 유건희, 임윤성, 조창건, 최세인, 최용준대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2016 · 제59권 제7호돌발성 난청 환자에서 전신 스테로이드 단독요법과 고실 내 스테로이드 병용요법의 치료 효과 비교이현진, 임소연, 장경일, 전은주대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2021 · 제64권 제3호

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