본문 바로가기
KERD
논문KCI 등재

돌발성 난청 환자에서 Lipoprostaglandin E1 과 Carbogen 흡입의 병행치료 효과에 관한 연구

The Study for Combined Therapeutic Effects of Lipoprostaglandin E1 with Carbogen Inhalation on Sudden Sensorineural Hearing Loss

김명구
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2008.01|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제51권 제1호|pp. 22-27

0

조회

0

다운로드

2

인용

0

참고문헌

키워드

Carbogen inhalation·Lipo-PGE1·Sudden hearing loss.
주제분류이비인후과학

초록

Sudden sensorineural hearing loss (SSNHL) is a disease, which occur rapidly within 3 days with unknown causes. Vascular and viral mechanisms are considered as the main cause, but an etiologcal background for vascular factors is more assumed. Carbogen inhalation and lipoprostaglandin E1, both of which have vasodilation effects, are used as treatment modalities in SSNHL. The purpose of this study was to recognize the effectiveness of lipo-PGE1 combined with carbogen inhalation, and to compare with other treatment modalities. Subjects and Method：The study group consisted of 224 patients (110 males, 114 females) diagnosed with SSNHL. We retrospectively reviewed patients who were admitted and treated from January 2001 to December 2005. All patients were treated with carbogen inhalation and drugs. Stellate ganglion block (SGB) and lipo-PGE1 were applied to patients selectively. Eighty-six patients (DCP group) were treated with lipo-PGE1, 49 patient (DCS group) with SGB, and 89 patients (DC group) without SGB. Results：The overall recovery rates after the treatment were 59.8%. Therapeutic results of lipo-PGE1 group were better than those of other groups. Conclusion : Although various treatments for SSNHL have been proposed, lipo-PGE1 and carbogen inhalation were more effective and lipo-PGE1 is considered to be more helpful for SSNHL. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:22-7)

Abstract

Sudden sensorineural hearing loss (SSNHL) is a disease, which occur rapidly within 3 days with unknown causes. Vascular and viral mechanisms are considered as the main cause, but an etiologcal background for vascular factors is more assumed. Carbogen inhalation and lipoprostaglandin E1, both of which have vasodilation effects, are used as treatment modalities in SSNHL. The purpose of this study was to recognize the effectiveness of lipo-PGE1 combined with carbogen inhalation, and to compare with other treatment modalities. Subjects and Method：The study group consisted of 224 patients (110 males, 114 females) diagnosed with SSNHL. We retrospectively reviewed patients who were admitted and treated from January 2001 to December 2005. All patients were treated with carbogen inhalation and drugs. Stellate ganglion block (SGB) and lipo-PGE1 were applied to patients selectively. Eighty-six patients (DCP group) were treated with lipo-PGE1, 49 patient (DCS group) with SGB, and 89 patients (DC group) without SGB. Results：The overall recovery rates after the treatment were 59.8%. Therapeutic results of lipo-PGE1 group were better than those of other groups. Conclusion : Although various treatments for SSNHL have been proposed, lipo-PGE1 and carbogen inhalation were more effective and lipo-PGE1 is considered to be more helpful for SSNHL. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:22-7)

참고문헌 (22)

  1. Wilson WR, "Viral and epidermiologic studies of idiopathic sudden hearing loss", Otolaryngol Head Neck Surg, 91(6), pp.653~658 (1983)
  2. Siegel LG, "The treatment of idiopathic sudden sensorineural hearing loss", Otolaryngol Clin North Am, 8(2), pp.467~473 (1975)
  3. Chandrasekhar SS, "Intratympanic dexamethasone for sudden sensorineural hearing loss: Clinical and laboratory evaluation", Otol Neurotol, 22(1), pp.18~23 (2001)
  4. Hughes GB, "Sudden sensorineural hearing loss", Otolaryngol Clin North Am, 29(3), pp.393~405 (1996)
  5. Mattox DE, "Idiopathic sudden sensorineural hearing loss", Am J Otol, 10(3), pp.242~247 (1989)
  6. Choung YH, "The comparison of hearing recovery of sudden deafness treated with different protocols", Korean J Audiol, 7(1), pp.24~31 (2003)
  7. Ahn JH, "Analysis of prognosis in patients with sudden sensorineural hearing loss and dizziness", Korean J Otolaryngol- Head Neck Surg, 44(10), pp.1032~1037 (2001)
  8. Wilson WR, "The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-bind clinical study", Arch Otolaryngol, 106(12), pp.772~776 (1980)
  9. 박용수, "돌발성 난청 환자에서 고실 내 스테로이드 주입의 효과", 대한이비인후과학회지 두경부외과학, 45(12), pp.1136~1140 (2002), 대한이비인후과학회
  10. Park SY, "The effect of combined antiviral agent therapy and stellate ganglion block for sudden sensorineural hearing loss and appropriate patients to evaluate the therapeutic effect", Korean J Otolaryngol-Head Neck Surg, 44(8), pp.817~821 (2001)
  11. Parnes LS, "Corticosteroid pharmacokinetics in the inner ear fluids: An animal study followed by clinical application", Laryngoscope, 109(7), pp.1~17 (1999)
  12. Stokroos RJ, "Therapy of idiopathic sudden sensorineural hearing loss: Antiviral treatment of experimental herpes simplex virus infection of the inner ear", Ann Otol Rhinol Laryngol, 108(5), pp.423~438 (1999)
  13. Kallinen J, "Sudden deafness: A comparison of anticoagulant therapy and carbogen inhalation therapy", Ann Otol Laryngol, 106(1), pp.22~26 (1997)
  14. Eun SJ, "The efficacy of stellate ganglion block in the treatment of idiopathic sudden sensorineural hearing loss", Korean J Otolaryngol- Head Neck Surg, 34(1), pp.28~33 (1991)
  15. 김학선, "돌발성 난청 환자에서 Carbogen 흡입과 성상신경절 차단술의 동시 치료 효과", 대한이비인후과학회지 두경부외과학, 45(3), pp.219~224 (2002), 대한이비인후과학회
  16. Nishimura T, "Effects of intravenous administration of prostaglandin E(1) and lipo-prostaglandin E(1) on cochlear blood flow in guinea pigs", Eur Arch Otorhinolaryngol, 259(5), pp.253~256 (2002)
  17. Ahn JH, "Therapeutic effect of lipoprostaglandin E1 on sudden hearing loss", Am J Otolaryngol, 26(4), pp.245~258 (2005)
  18. Murray KJ, "Cyclic AMP and mechanism of vasodilation", Pharmacol Ther, 47(3), pp.329~345 (1990)
  19. Salganicoff L, "An hypothesis on the consolidation and PGE1-induced deconsolidation of a platelet plug", Platelets, 14(7), pp.463~471 (2003)
  20. Nakashima T, "Evaluation of prostaglandin E1 therapy for sudden deafness", Laryngoscope, 99(5), pp.542~546 (1989)
  21. 안중호, "제2형 당뇨환자에서 발생한 돌발성 난청의 치료제로서 Lipo-Prostalandin E₁의 효능분석", 대한이비인후과학회지 두경부외과학, 49(10), pp.973~977 (2006), 대한이비인후과학회
  22. Ogawa K, "Effect of prostaglandin E1 on idiopathic sudden sensorineural hearing loss: A double-blinded clinical study", Otol Neurotol, 23(5), pp.665~668 (2002)

이 간행물의 다른 논문 (11건)

만성 화농성 중이염의 세균학적 고찰 : Methicilin-Resistant Staphylococcus Aureus와 Pseudomonas Aeruginosa의 검출률의 변화이영찬, 차창일, 김성완, 홍창기, 홍석민, 여승근, 심주섭, 이선규pp. 9-15기니아 피그 고막에서 성체신경줄기세포의 분리 배양김준규, 이병훈, 김부영, 이창훈, 박시내, 백지혜, 장기홍, 여상원, 배성천, 박경호, 성용해, 배민영pp. 28-32개방동 유양돌기절제술 후 시행한 외이도후벽 재건술과 유양동폐쇄술박종률, 한치성, 오재규, 정을현, 김종애, 김현범, 이원용, 안중기, 강명구, 구태우pp. 33-40사람 코점막 상피세포에서 Interleukin-1β에 의한 Caveolin-1 발현의 감소박창신, 김보묵, 김민욱, 윤셕영, 신미경, 최윤석, 한길수, 장태영pp. 46-50비인강암의 치료방법에서 Docetaxel과 Platinum을 이용한 유도항암요법의 효과홍기환, 공일승, 권삼현, 양윤수, 최동일pp. 58-63
원문 보기