돌발성 난청 환자에서 전신 스테로이드 단독요법과 고실 내 스테로이드 병용요법의 치료 효과 비교
Comparison of Hearing Outcomes of Systemic Steroid Monotherapy and Intratympanic Steroid Combined Treatment in Idiopathic Sudden Sensorineural Hearing Loss
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Background and Objectives Steroid treatment is used as a main treatment modality forsudden sensorineural hearing loss (SSNHL). Intratympanic injection of steroid (ITS) has beenused and its therapeutic efficacy reported as being comparable to the systemic steroid administration(SS). This study compares the hearing outcomes of using ITS and SS simultaneouslyand SS alone. Subjects and Method Retrospective chart review was performed for 146 patients withSSNHL. The patients were divided into 2 groups according to the method of treatment (SSand ITS simultaneously vs. SS alone). The inclusion criteria were starting treatment within 7days after onset, and follow up pure tone audiometry at least 4 weeks after treatment. Hearinggain for pure tone threshold of each frequency and average of 4 frequencies (500 Hz, 1000 Hz,2000 Hz, and 4000 Hz) were compared between both groups. Results The improvement in PTA at 1-month follow-up was 27.3±20.0 dB HL in the simultaneousgroup and 19.1±19.5 dB HL in the SS alone group; this was not statistically significant. Complete or partial recovery at 1-month follow-up was observed in 65.3% of the simultaneousgroup and 69.6% of the SS alone group; this was also not significant. Conclusion There was no significant difference in hearing outcomes between the simultaneousand SS alone group. The simultaneous therapy does not appear to be superior to the SS alonetherapy. Further studies using more population and longer follow-up periods are necessary.
Abstract
Background and Objectives Steroid treatment is used as a main treatment modality forsudden sensorineural hearing loss (SSNHL). Intratympanic injection of steroid (ITS) has beenused and its therapeutic efficacy reported as being comparable to the systemic steroid administration(SS). This study compares the hearing outcomes of using ITS and SS simultaneouslyand SS alone. Subjects and Method Retrospective chart review was performed for 146 patients withSSNHL. The patients were divided into 2 groups according to the method of treatment (SSand ITS simultaneously vs. SS alone). The inclusion criteria were starting treatment within 7days after onset, and follow up pure tone audiometry at least 4 weeks after treatment. Hearinggain for pure tone threshold of each frequency and average of 4 frequencies (500 Hz, 1000 Hz,2000 Hz, and 4000 Hz) were compared between both groups. Results The improvement in PTA at 1-month follow-up was 27.3±20.0 dB HL in the simultaneousgroup and 19.1±19.5 dB HL in the SS alone group; this was not statistically significant. Complete or partial recovery at 1-month follow-up was observed in 65.3% of the simultaneousgroup and 69.6% of the SS alone group; this was also not significant. Conclusion There was no significant difference in hearing outcomes between the simultaneousand SS alone group. The simultaneous therapy does not appear to be superior to the SS alonetherapy. Further studies using more population and longer follow-up periods are necessary.
참고문헌 (19)
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