Analysis Between Kidney Function and Hearing Loss Using Hemodynamic and Physical Characteristics: A Large Cross-Sectional Cohort Study With Health Screening Test
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Background and Objectives A large-scale community-based study of the general populationhas not been conducted. There have been no studies on the relationship between decreasedrenal function and the degree of hearing loss. Thus, the purpose was to evaluate the relationshipbetween hearing loss and impaired renal function with a large number of populations. Subjects and Method We performed a cross-sectional population-based cohort study byenrolling 470718 adults, 18 to 80 years old with pure tone audiometry tests who had regularhealth screening between 2013 and 2018. Hearing loss was defined as a pure-tone average ofthresholds at 500, 1000, and 2000 Hz in both right and left ears. Kidney function was evaluatedbased on eGFR. Chronic kidney disease (CKD) was diagnosed as an eGFR<60 mL/min/1.73 m². Other predictor variables including noise and age that can affect hearing werealso used to evaluate correlation factors. Results Of Participants with CKD, 14.2% had any hearing loss (>25 dB) and 5.0% had abovemoderate hearing loss (>40 dB). But those with normal kidney function, 2.0% either had anyhearing loss and 0.4% had above moderate hearing loss. The odds ratio (OR) of above moderatehearing loss for participants with CKD was 1.51 (95% confidence interval [CI]: 1.15-2.00,p=0.003) but the OR of mild hearing loss for participants with CKD was 0.82 (95% CI: 0.67-1.02, p=0.073). The result suggested that CKD and above moderate hearing loss were relatedeven after correcting for potential confounders, but had no statistical significance with mildhearing loss.
Abstract
Background and Objectives A large-scale community-based study of the general populationhas not been conducted. There have been no studies on the relationship between decreasedrenal function and the degree of hearing loss. Thus, the purpose was to evaluate the relationshipbetween hearing loss and impaired renal function with a large number of populations. Subjects and Method We performed a cross-sectional population-based cohort study byenrolling 470718 adults, 18 to 80 years old with pure tone audiometry tests who had regularhealth screening between 2013 and 2018. Hearing loss was defined as a pure-tone average ofthresholds at 500, 1000, and 2000 Hz in both right and left ears. Kidney function was evaluatedbased on eGFR. Chronic kidney disease (CKD) was diagnosed as an eGFR<60 mL/min/1.73 m². Other predictor variables including noise and age that can affect hearing werealso used to evaluate correlation factors. Results Of Participants with CKD, 14.2% had any hearing loss (>25 dB) and 5.0% had abovemoderate hearing loss (>40 dB). But those with normal kidney function, 2.0% either had anyhearing loss and 0.4% had above moderate hearing loss. The odds ratio (OR) of above moderatehearing loss for participants with CKD was 1.51 (95% confidence interval [CI]: 1.15-2.00,p=0.003) but the OR of mild hearing loss for participants with CKD was 0.82 (95% CI: 0.67-1.02, p=0.073). The result suggested that CKD and above moderate hearing loss were relatedeven after correcting for potential confounders, but had no statistical significance with mildhearing loss.
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