Disability of Hearing Impairment Is Positively Associated With Urine Albumin/Creatinine Ratio in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives. The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. Methods. This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio (ACR) was measured from first-voided spot urine samples. The air-conduction hearing threshold was measured at 0.5, 1, 2, 3, 4, and 6 kHz and pure tone audiogram (PTA) average was calculated as the four-frequency average of 0.5, 1, 2, and 4 kHz. Results. Urine ACR was significantly correlated with the PTA average of better ear in both genders, especially at 3 and 6 kHz in males and at 1, 3, 4, and 6 kHz in females. After adjusting, urine ACR also increased the risk of hearing loss in female, especially if urine ACR was 30 mg/g and more (odds ratio, 1.636–2.229. This study showed that the degree of hearing loss was significantly different according to categories of urine ACR in both genders. Hearing loss without disability was found less but that with bilateral hearing disability was found more as urine ACR increased. In generally, prevalence of hearing loss with disability was higher in males than females. Conclusion. This study demonstrated that urine ACR was significantly correlated with the PTA average of better ear in Korean adults of both genders. This study suggests that clinicians should carefully monitor the hearing level for subjects with elevated urine ACR, even though high urine ACR within the normal range.
Abstract
Objectives. The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. Methods. This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio (ACR) was measured from first-voided spot urine samples. The air-conduction hearing threshold was measured at 0.5, 1, 2, 3, 4, and 6 kHz and pure tone audiogram (PTA) average was calculated as the four-frequency average of 0.5, 1, 2, and 4 kHz. Results. Urine ACR was significantly correlated with the PTA average of better ear in both genders, especially at 3 and 6 kHz in males and at 1, 3, 4, and 6 kHz in females. After adjusting, urine ACR also increased the risk of hearing loss in female, especially if urine ACR was 30 mg/g and more (odds ratio, 1.636–2.229. This study showed that the degree of hearing loss was significantly different according to categories of urine ACR in both genders. Hearing loss without disability was found less but that with bilateral hearing disability was found more as urine ACR increased. In generally, prevalence of hearing loss with disability was higher in males than females. Conclusion. This study demonstrated that urine ACR was significantly correlated with the PTA average of better ear in Korean adults of both genders. This study suggests that clinicians should carefully monitor the hearing level for subjects with elevated urine ACR, even though high urine ACR within the normal range.
참고문헌 (27)
- Fetoni AR., "Pathogenesis of presbycusis in animal models : a review", Exp Gerontol, 46(6), pp.413~425 (2011)
- Yamasoba T., "Current concepts in age-related hearing loss : epidemiology and mechanistic pathways", Hear Res, 303, pp.30~38 (2013)
- Adler D., "Inhibition of Na+,K+-stimulated ATPase in the cochlea of the guinea pig: a potential cause of disturbed inner ear function in terminal renal failure", Acta Otolaryngol, 90(1-2), pp.55~60 (1980)
- Ohashi T., "Cochlear function of guinea pigs with experimental chronic renal failure", Ann Otol Rhinol Laryngol, 108(10), pp.10~ (1999)
- Kang SH., "The association between metabolic syndrome or chronic kidney disease and hearing thresholds in Koreans: the Korean National Health and Nutrition Examination Survey 2009-2012", PLoS One, 10(3), pp.e0120372~ (2015)
- Shen FC., "Severity of hearing impairment is positively associated with urine albumin excretion rate in patients with type 2 diabetes", J Diabetes Investig, 5(6), pp.743~747 (2014)
- Jacobs DR Jr., "Gender-and race-specific determination of albumin excretion rate using albumin-to-creatinine ratio in single, untimed urine specimens : the Coronary Artery Risk Development in Young Adults Study", Am J Epidemiol, 155(12), pp.1114~1119 (2002)
- Mattix HJ., "Use of the albumin", creatinine ratio to detect microalbuminuria : implications of sex and race, 2002, pp.13(4), 1034~1039
- Forman JP., "Higher levels of albuminuria within the normal range predict incident hypertension", J Am Soc Nephrol, 19(10), pp.1983~1988 (2008)
- Wachtell K., "Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy : the LIFE study", Ann Intern Med, 139(11), pp.901~906 (2003)
- Gerstein HC., "Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals", JAMA, 286(4), pp.421~426 (2001)
- Mehta D., "Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus", Metabolism, 63(11), pp.1390~1397 (2014)
- Kweon S., "Data resource profile : the Korea National Health and Nutrition Examination Survey(KNHANES)", Int J Epidemiol, 43(1), pp.69~77 (2014)
- Diaz de Leon-Morales LV., "Auditory impairment in patients with type 2 diabetes mellitus", Arch Med Res, 36(5), pp.507~510 (2005)
- Bainbridge KE., "Diabetes and hearing impairment in the United States : audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004", Ann Intern Med, 149(1), pp.1~10 (2008)
- Lerman-Garber I., "Sensorineural hearing loss : a common finding in early-onset type 2 diabetes mellitus", Endocr Pract, 18(4), pp.549~557 (2012)
- Abd El Dayem SM., "Assessment of hearing in children with type 1 diabetes mellitus", J Pediatr Endocrinol Metab, 27(5-6), pp.393~402 (2014)
- Konrad-Martin D., "Hearing impairment in relation to severity of diabetes in a veteran cohort", Ear Hear, 36(4), pp.381~394 (2015)
- Kang JW., "Dietary vitamin intake correlates with hearing thresholds in the older population : the Korean National Health and Nutrition Examination Survey", Am J Clin Nutr, 99(6), pp.1407~1413 (2014)
- Hong JW., "The prevalence and factors associated with hearing impairment in the Korean adults: the 2010-2012 Korea National Health and Nutrition Examination Survey (observational study)", Medicine (Baltimore), 94(10), pp.e611~ (2015)
- Lee JS., "Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss", PLoS One, 10(4), pp.e0122496~ (2015)
- Ra H., "Predictors for diabetic retinopathy in normoalbuminuric people with type 2 diabetes mellitus", Diabetol Metab Syndr, 4(1), pp.29~ (2012)
- Yoon HE., "High normal albuminuria is associated with arterial stiffness and carotid atherosclerosis in Korean patients with type 2 diabetes", Nutr Metab Cardiovasc Dis, 25(8), pp.787~794 (2015)
- Liu JJ., "High normal albuminuria is independently associated with aortic stiffness in patients with Type 2 diabetes", Diabet Med, 31(10), pp.1199~1204 (2014)
- Leoncini G., "Microalbuminuria is an integrated marker of subclinical organ damage in primary hypertension", J Hum Hypertens, 16(6), pp.399~404 (2002)
- Leoncini G., "Mild renal dysfunction and cardiovascular risk in hypertensive patients", J Am Soc Nephrol, 15(Suppl 1), pp.S88~S90 (2004)
- Whitmer WM., "Proposed norms for the Glasgow hearing-aid benefit profile(Ghabp)questionnaire", Int J Audiol, 53(5), pp.345~351 (2014)