The Relationship Between Chronic Rhinosinusitis Endotype With Peripheral Blood Eosinophil, Eosinophil-Neutrophil Ratio, and Total Serum IgE
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Background and Objectives Chronic rhinosinusitis (CRS) is an inflammatory diseasewhich has a complex etiopathogenesis and can be a significant burden on the patient andhealth systems. Based on European Position Paper on Rhinosinusitis and Nasal Polyps, peripheralblood eosinophil and total serum IgE are markers of inflammation type 2 CRS endotype. However, there is a marked global heterogeneity in inflammatory endotypes among patientswith CRS without nasal polyps (CRSsNP) or CRS with nasal polyps (CRSwNP) amongthe Asians and Caucasians with CRS. To determine the concurrence between CRS endotypesbiomarkers with peripheral blood eosinophil, eosinophil-neutrophil ratio (ENR), and total serumimmunoglobulin E (IgE) in the diagnosis of CRS. Subjects and Method This study used an observational analytic study with a cross-sectionaldesign, with total of 26 patients were included in this study. Examination of endotype biomarkerswas carried out using the enzyme-linked immunosorbent assay method and peripheral bloodeosinophil, ENR, and total serum IgE were taken from routine hematological examinations. Results We found a significant relationship between ENR values and CRS endotypes (p=0.021); however, there was no relationship found between the values of peripheral blood eosinophiland total serum IgE with CRS endotypes (p>0.05). The ENR value ≥0.06 has a 6.14times greater risk of developing type 2 inflammation (95% confidence interval 1.64-23; p<0.001). Conclusion There is s a relationship between ENR values and CRS endotypes.
Abstract
Background and Objectives Chronic rhinosinusitis (CRS) is an inflammatory diseasewhich has a complex etiopathogenesis and can be a significant burden on the patient andhealth systems. Based on European Position Paper on Rhinosinusitis and Nasal Polyps, peripheralblood eosinophil and total serum IgE are markers of inflammation type 2 CRS endotype. However, there is a marked global heterogeneity in inflammatory endotypes among patientswith CRS without nasal polyps (CRSsNP) or CRS with nasal polyps (CRSwNP) amongthe Asians and Caucasians with CRS. To determine the concurrence between CRS endotypesbiomarkers with peripheral blood eosinophil, eosinophil-neutrophil ratio (ENR), and total serumimmunoglobulin E (IgE) in the diagnosis of CRS. Subjects and Method This study used an observational analytic study with a cross-sectionaldesign, with total of 26 patients were included in this study. Examination of endotype biomarkerswas carried out using the enzyme-linked immunosorbent assay method and peripheral bloodeosinophil, ENR, and total serum IgE were taken from routine hematological examinations. Results We found a significant relationship between ENR values and CRS endotypes (p=0.021); however, there was no relationship found between the values of peripheral blood eosinophiland total serum IgE with CRS endotypes (p>0.05). The ENR value ≥0.06 has a 6.14times greater risk of developing type 2 inflammation (95% confidence interval 1.64-23; p<0.001). Conclusion There is s a relationship between ENR values and CRS endotypes.
참고문헌 (30)
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