본문 바로가기
KERD
논문KCI 등재

Clinical and Laboratory Features of Various Criteria of Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis

김성원|황세환|Mohammed Abdullah Basurrah|김도현
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2022.08|Clinical and Experimental Otorhinolaryngology|제15권 제3호|pp. 230-246|DOI https://doi.org/10.21053/ceo.2022.00052

2

조회

0

다운로드

10

인용

0

참고문헌

키워드

BiomarkerTomographySinusitisEndoscopyEosinophilsX-Ray Computed

초록

Objectives. The aim of this study was to evaluate the differences in clinical and laboratory features between eosinophilic chronic rhinosinusitis (ECRS) and non-ECRS and to compare diagnostic criteria for ECRS. Methods. We compared clinical features and/or laboratory findings classified as ECRS and non-ECRS according to various diagnostic criteria (histological and clinical). We also analyzed studies to compare endoscopic findings, symptom scores, laboratory findings, and computed tomography (CT) findings between ECRS and non-ECRS. Results. Our search included 55 studies with 6,143 patients. A comparison of clinical features and/or laboratory criteria with histological criteria showed no significant differences in nasal symptom scores and CT scores according to criteria. Serum eosinophil levels showed differences across the criteria, with ECRS consistently characterized by higher serum eosinophil levels than non-ECRS. Among the four criteria, the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) criteria and tissue eosinophilia (≥70) were associated with decreased olfactory function. In laboratory findings, the eosinophil percentage (standardized mean difference [SMD], 1.561; 95% confidence interval [CI], 1.329–1.794; P<0.001) and eosinophil count (SMD, 1.493; 95% CI, 1.134–1.852; P<0.001) of eosinophils were higher in ECRS than non-ECRS. In clinical findings, nasal symptom scores (SMD, 0.382; 95% CI, 0.156–0.608; P<0.001), endoscopic nasal polyp scores (SMD, 0.581; 95% CI, 0.314–0.848; P<0.001), and olfactory dysfunction (SMD, 0.416; 95% CI, 0.037–0.794; P=0.031) were higher in ECRS than in non-ECRS. With regard to CT findings, the whole-sinus opacification score (SMD, 0.824; 95% CI, 0.588–1.059; P<0.001) was higher in ECRS than in non-ECRS. In particular, there were significant differences in anterior ethmoid sinus and sphenoid sinus opacification. Conclusion. ECRS and non-ECRS differ in their clinical and laboratory features. When histological confirmation is difficult on an outpatient basis, ECRS could be diagnosed using clinical features and/or laboratory findings.

Abstract

Objectives. The aim of this study was to evaluate the differences in clinical and laboratory features between eosinophilic chronic rhinosinusitis (ECRS) and non-ECRS and to compare diagnostic criteria for ECRS. Methods. We compared clinical features and/or laboratory findings classified as ECRS and non-ECRS according to various diagnostic criteria (histological and clinical). We also analyzed studies to compare endoscopic findings, symptom scores, laboratory findings, and computed tomography (CT) findings between ECRS and non-ECRS. Results. Our search included 55 studies with 6,143 patients. A comparison of clinical features and/or laboratory criteria with histological criteria showed no significant differences in nasal symptom scores and CT scores according to criteria. Serum eosinophil levels showed differences across the criteria, with ECRS consistently characterized by higher serum eosinophil levels than non-ECRS. Among the four criteria, the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) criteria and tissue eosinophilia (≥70) were associated with decreased olfactory function. In laboratory findings, the eosinophil percentage (standardized mean difference [SMD], 1.561; 95% confidence interval [CI], 1.329–1.794; P<0.001) and eosinophil count (SMD, 1.493; 95% CI, 1.134–1.852; P<0.001) of eosinophils were higher in ECRS than non-ECRS. In clinical findings, nasal symptom scores (SMD, 0.382; 95% CI, 0.156–0.608; P<0.001), endoscopic nasal polyp scores (SMD, 0.581; 95% CI, 0.314–0.848; P<0.001), and olfactory dysfunction (SMD, 0.416; 95% CI, 0.037–0.794; P=0.031) were higher in ECRS than in non-ECRS. With regard to CT findings, the whole-sinus opacification score (SMD, 0.824; 95% CI, 0.588–1.059; P<0.001) was higher in ECRS than in non-ECRS. In particular, there were significant differences in anterior ethmoid sinus and sphenoid sinus opacification. Conclusion. ECRS and non-ECRS differ in their clinical and laboratory features. When histological confirmation is difficult on an outpatient basis, ECRS could be diagnosed using clinical features and/or laboratory findings.

참고문헌 (73)

  1. McHugh T, "Comorbidities associated with eosinophilic chronic rhinosinusitis : a systematic review and meta-analysis", Clin Otolaryngol, 45(4), pp.574~583 (2020)
  2. Wang ET, "Eosinophilic chronic rhinosinusitis in East Asians", World J Clin Cases, 2(12), pp.873~882 (2014)
  3. Hu Y, "Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults", Laryngoscope, 122(3), pp.498~503 (2012)
  4. Sakuma Y, "New clinical diagnostic criteria for eosinophilic chronic rhinosinusitis", Auris Nasus Larynx, 38(5), pp.583~588 (2011)
  5. Tokunaga T, "Novel scoring system and algorithm for classifying chronic rhinosinusitis : the JESREC Study", Allergy, 70(8), pp.995~1003 (2015)
  6. Moher D, "Preferred reporting items for systematic reviews and meta-analyses : the PRISMA statement", BMJ, 339, pp.b2535~ (2009)
  7. 김도현, "Predictive Value of Olfactory and Taste Symptoms in the Diagnosis of COVID-19: A Systematic Review and Meta-Analysis", Clinical and Experimental Otorhinolaryngology, 14(3), pp.312~320 (2021), 대한이비인후과학회[DOI]
  8. 김도현, "The Efficacy of Hypotensive Agents on Intraoperative Bleeding and Recovery Following General Anesthesia for Nasal Surgery: A Network Meta-Analysis", Clinical and Experimental Otorhinolaryngology, 14(2), pp.200~209 (2021), 대한이비인후과학회[DOI]
  9. Ky LM, "Pathogenesis of eosinophilic vs. non-eosinophilic chronic rhinosinusitis with nasal polyposis in Vietnamese", Genet Mol Res, 20(1), pp.gmr18733~ (2021)
  10. Takeno S, "Increased exhaled nitric oxide and its oxidation metabolism in eosinophilic chronic rhinosinusitis", Auris Nasus Larynx, 40(5), pp.458~464 (2013)
  11. Kim DK, "Non-eosinophilic nasal polyps shows increased epithelial proliferation and localized disease pattern in the early stage", PLoS One, 10(10), pp.e0139945~ (2015)
  12. Meng Y, "Predictive significance of computed tomography in eosinophilic chronic rhinosinusitis with nasal polyps", Int Forum Allergy Rhinol, 6(8), pp.812~819 (2016)
  13. Tojima I, "Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis", Clin Immunol, 170, pp.1~8 (2016)
  14. Baba S, "Distribution, subtype population, and IgE positivity of mast cells in chronic rhinosinusitis with nasal polyps", Ann Allergy Asthma Immunol, 119(2), pp.120~128 (2017)
  15. Kambara R, "Lower airway inflammation in eosinophilic chronic rhinosinusitis as determined by exhaled nitric oxide", Int Arch Allergy Immunol, 173(4), pp.225~232 (2017)
  16. Kubota K, "IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients", J Otolaryngol Head Neck Surg, 46(1), pp.36~ (2017)
  17. Sreeparvathi A, "Significance of blood eosinophil count in patients with chronic rhinosinusitis with nasal polyposis", J Clin Diagn Res, 11(2), pp.MC08~MC11 (2017)
  18. Xu M, "The role of periostin in the occurrence and progression of eosinophilic chronic sinusitis with nasal polyps", Sci Rep, 7(1), pp.9479~ (2017)
  19. Ho J, "Systemic predictors of eosinophilic chronic rhinosinusitis", Am J Rhinol Allergy, 32(4), pp.252~257 (2018)
  20. Tsuda T, "Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity", Int Immunol, 31(1), pp.33~40 (2019)
  21. Uraguchi K, "Pulmonary function in patients with eosinophilic chronic rhinosinusitis", Auris Nasus Larynx, 45(3), pp.476~481 (2018)
  22. Wakayama N, "Delayed type of allergic skin reaction to Candida albicans in eosinophilic rhinosinusitis cases", Auris Nasus Larynx, 45(1), pp.111~115 (2018)
  23. Hwang CS, "Eosinophil extracellular trap formation is closely associated with disease severity in chronic rhinosinusitis regardless of nasal polyp status", Sci Rep, 9(1), pp.8061~ (2019)
  24. Ito T, "Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps", Braz J Otorhinolaryngol, 85(6), pp.760~765 (2019)
  25. Kashiwagi T, "Postoperative evaluation of olfactory dysfunction in eosinophilic chronic rhinosinusitis : comparison of histopathological and clinical findings", Acta Otolaryngol, 139(10), pp.881~889 (2019)
  26. 김진엽, "Revisiting the Clinical Scoring System for the Prognosis of Chronic Rhinosinusitis with Nasal Polyps", Yonsei Medical Journal, 60(6), pp.578~584 (2019), 연세대학교의과대학[DOI]
  27. Liu C, "Predictive significance of Charcot-Leyden crystals for eosinophilic chronic rhinosinusitis with nasal polyps", Am J Rhinol Allergy, 33(6), pp.671~680 (2019)
  28. Nakayama T, "JESREC score and mucosal eosinophilia can predict endotypes of chronic rhinosinusitis with nasal polyps", Auris Nasus Larynx, 46(3), pp.374~383 (2019)
  29. Shen KH, "Differential effects of postoperative oral corticosteroid on eosinophilic vs. non-eosinophilic CRSwNP subtypes", Am J Otolaryngol, 40(1), pp.22~29 (2019)
  30. Tsuzuki K, "Predictors of disease progression after endoscopic sinus surgery in patients with chronic rhinosinusitis", J Laryngol Otol, 133(8), pp.678~684 (2019)
  31. Wang F, "Histopathologic analysis in chronic rhinosinusitis : impact on quality of life outcomes", Am J Otolaryngol, 40(3), pp.423~426 (2019)
  32. Yoshida K, "Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis", Allergol Int, 68(2), pp.225~232 (2019)
  33. Fadda GL, "Multiparametric analysis of factors associated with eosinophilic chronic rhinosinusitis with nasal polyps", Ear Nose Throat J (2020)[DOI]
  34. Imoto Y, "Enhanced 15-lipoxygenase 1 production is related to periostin expression and eosinophil recruitment in eosinophilic chronic rhinosinusitis", Biomolecules, 10(11), pp.1568~ (2020)
  35. Lv H, "Predictive and diagnostic value of nasal nitric oxide in eosinophilic chronic rhinosinusitis with nasal polyps", Int Arch Allergy Immunol, 181(11), pp.853~861 (2020)
  36. Sivrice ME, "Can the systemic immune inflammation index preoperatively predict nasal polyp subtypes?", Eur Arch Otorhinolaryngol, 277(11), pp.3045~3050 (2020)
  37. Xu Q, "Application of clinical scores in the differential diagnosis of chronic rhinosinusitis with nasal polyps in a chinese population", Am J Rhinol Allergy, 34(3), pp.401~408 (2020)
  38. Yao Y, "Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis", Biosci Rep, 40(2), pp.BSR20193101~ (2020)
  39. Yun Y, "Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings", Allergol Int, 69(2), pp.232~238 (2020)
  40. Zhu M, "The roles of nasal nitric oxide in diagnosis and endotypes of chronic rhinosinusitis with nasal polyps", J Otolaryngol Head Neck Surg, 49(1), pp.68~ (2020)
  41. Zhu Z, "Nasal fluid cytology and cytokine profiles of eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps", Rhinology, 58(4), pp.314~322 (2020)
  42. Ahn SH, "Comparison of olfactory and taste functions between eosinophilic and non-eosinophilic chronic rhinosinusitis", Auris Nasus Larynx, 47(5), pp.820~827 (2020)
  43. Abbas EE, "Distinct clinical pathology and microbiota in chronic rhinosinusitis with nasal polyps endotypes", Laryngoscope, 131(1), pp.E34~E44 (2021)
  44. Feng T, "Sinus microbiota in patients with eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps", Front Cell Infect Microbiol, 11, pp.672355~ (2021)
  45. Kawasumi T, "Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitis", J Laryngol Otol, 135(9), pp.773~778 (2021)
  46. Kowalik K, "The SWI", SNF complex in eosinophilic and non eosinophilic chronic rhinosinusitis, 2021, pp.41(2), 159~167
  47. Rha MS, "IL-17A-producing sinonasal MAIT cells in patients with chronic rhinosinusitis with nasal polyps", J Allergy Clin Immunol, 149(2), pp.599~609 (2022)
  48. Takahashi K, "Evaluation of olfactory dysfunction to estimate the presence of eosinophilic chronic rhinosinusitis in patients with asthma", Respir Investig, 59(1), pp.126~134 (2021)
  49. Terada T, "Effects of endoscopic sinus surgery for eosinophilic chronic rhinosinusitis on respiratory functions and FeNO production in the lower respiratory tract", Ear Nose Throat J (2021)[DOI]
  50. Wang Y, "Role of P2X7R in eosinophilic and non‑eosinophilic chronic rhinosinusitis with nasal polyps", Mol Med Rep, 24(1), pp.521~ (2021)
  51. Zhong B, "The role of preoperative blood eosinophil counts in distinguishing chronic rhinosinusitis with nasal polyps phenotypes", Int Forum Allergy Rhinol, 11(1), pp.16~23 (2021)
  52. Nakayama T, "Mucosal eosinophilia and recurrence of nasal polyps : new classification of chronic rhinosinusitis", Rhinology, 49(4), pp.392~396 (2011)
  53. Kouzaki H, "Epithelial cell-derived cytokines contribute to the pathophysiology of eosinophilic chronic rhinosinusitis", J Interferon Cytokine Res, 36(3), pp.169~179 (2016)
  54. Okada N, "Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non-eosinophilic chronic rhinosinusitis", Int Forum Allergy Rhinol, 8(5), pp.592~604 (2018)
  55. Snidvongs K, "Structured histopathology profiling of chronic rhinosinusitis in routine practice", Int Forum Allergy Rhinol, 2(5), pp.376~385 (2012)
  56. Cao PP, "Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non-eosinophilic, chronic rhinosinusitis with nasal polyps", Clin Exp Allergy, 44(5), pp.690~700 (2014)
  57. Lin D, "Expression and role of BAG-1 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps", Inflammation, 37(6), pp.1912~1918 (2014)
  58. Lin H, "Role of NLRP3 inflammasome in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps", Inflammation, 39(6), pp.2045~2052 (2016)
  59. Aslan F, "Could eosinophilia predict clinical severity in nasal polyps?", Multidiscip Respir Med, 12, pp.21~ (2017)
  60. Liao B, "Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps", Allergy, 70(9), pp.1169~1180 (2015)
  61. Snidvongs K, "Eosinophilic rhinosinusitis is not a disease of ostiomeatal occlusion", Laryngoscope, 123(5), pp.1070~1074 (2013)
  62. Chitsuthipakorn W, "Endotypes of chronic rhinosinusitis across ancestry and geographic regions", Curr Allergy Asthma Rep, 18(9), pp.46~ (2018)
  63. Lin H, "Increased expression of TXNIP facilitates oxidative stress in nasal epithelial cells of patients with chronic rhinosinusitis with nasal polyps", Am J Rhinol Allergy, 35(5), pp.607~614 (2021)
  64. Topal O, "Oxidative stress and nasal polyposis: does it affect the severity of the disease?", Am J Rhinol Allergy, 28(1), pp.e1~e4 (2014)
  65. Bosnjak B, "Treatment of allergic asthma : modulation of Th2 cells and their responses", Respir Res, 12(1), pp.114~ (2011)
  66. Deo SS, "Role played by Th2 type cytokines in IgE mediated allergy and asthma", Lung India, 27(2), pp.66~71 (2010)
  67. Ryu G, "Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis", Curr Opin Allergy Clin Immunol, 20(1), pp.1~8 (2020)
  68. Lotsch J, "Clinical usefulness of self-rated olfactory performance : a data science-based assessment of 6000 patients", Chem Senses, 44(6), pp.357~364 (2019)
  69. Lin SH, "Survey of the frequency of olfactory dysfunction in Taiwan", J Chin Med Assoc, 72(2), pp.68~71 (2009)
  70. McHugh T, "High tissue eosinophilia as a marker to predict recurrence for eosinophilic chronic rhinosinusitis : a systematic review and meta-analysis", Int Forum Allergy Rhinol, 8(12), pp.1421~1429 (2018)
  71. Toro MD, "Achieving the best method to classify eosinophilic chronic rhinosinusitis : a systematic review", Rhinology, 59(4), pp.330~339 (2021)
  72. Ortega H, "Effects of systemic corticosteroids on blood eosinophil counts in asthma : real-world data", J Asthma, 56(8), pp.808~815 (2019)
  73. Vaidyanathan S, "Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids : a randomized trial", Ann Intern Med, 154(5), pp.293~302 (2011)

관련 논문AI추천

Differences in Clinical and Immunological Characteristics According to the Various Criteria for Tissue Eosinophilia in Chronic Rhinosinusitis With Nasal Polyps김정훈, 양승구, 원태빈, 이재서, 조성우, 한연비대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2023 · 제16권 제4호Do Eosinophilic Polyps Act as a Reliable Predictor of Olfactory Dysfunction and Postoperative Recovery in Chronic Rhinosinusitis?김진국, 양영수, 임동혁, 조재훈, 최혜랑, 한규진, 홍석찬대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2018 · 제61권 제6호Categorization and Clinicopathological Features of Chronic Rhinosinusitis With Eosinophilic Mucin in a Korean Population김용민, 김학준, 나기상, 윤영훈, 이석호, 이진우대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2015 · 제8권 제1호The Relationship Between Chronic Rhinosinusitis Endotype With Peripheral Blood Eosinophil, Eosinophil-Neutrophil Ratio, and Total Serum IgEHendradi Surjotomo, Iriana Maharani, Nanik Setijowati, Widia Isa Aprillia Sujana대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2024 · 제67권 제10호The Correlation of Tissue’s Endotype Biomarkers and Dominant Inflammation Cell in Chronic RhinosinusitisDyah Indrasworo, Iriana Maharani, Kenty Wantri Anita, Monica Intan대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2024 · 제67권 제3호한국 환자를 대상으로 한 비용종이 있는 호산구 및 중성구성 만성 비부비동염의 임상적 특징 및치료 후 예후 분석김은희, 김채영, 모지훈, 배준상, 변광현, 유신혁대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2024 · 제67권 제6호

이 간행물의 다른 논문 (9건)

Tinnitus and the Triple Network Model: A PerspectiveDirk De Ridder, Divya Adhia, Sven Vanneste, 송재진pp. 205-212Saccular Pathology Is Most Commonly Found in Patients With General Vestibular Disorders김정기, 신승호, 김성헌, 심대보, 나지나, 이전미, 이현진pp. 213-219Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss김태경, 최영미, 이성수, 이창준, 조형호, Alphonse Umugirepp. 220-229Presentation Patterns and Surgical Management of the Complications of Thread Rhinoplasty진홍률, 김수진pp. 247-253Aeroallergen Sensitization Status in South Korea From 2018 to 2021조재훈, 김진국, 김수현, 김인태, 민도식pp. 254-263
원문 보기