본문 바로가기
KERD
논문KCI 등재

Anti-vascular endothelial growth factor receptor in colorectal cancer: A review

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

In recent years, the treatment of metastatic colorectal cancer (mCRC) has dramatically changed thanks to the advent of new drugs called molecular targeted therapies such as anti-vascular endothelial growth factor (anti-VEGF) and anti-epidermal growth factor (anti-EGFR). Bevacizumab, aflibercept and ramucirumab which belong to the first category, have been used for many years in clinical practice, achieving improvements in progression- free survival and overall survival in many phase III trials. These agents act by blocking the growth of the tumor vascular bed via the inhibition of neoangiogenesis. This review summarizes all available data in the literature on bevacizumab, aflibercept, and ramucirumab and describes their use in the continuum of care of mCRC.

Abstract

In recent years, the treatment of metastatic colorectal cancer (mCRC) has dramatically changed thanks to the advent of new drugs called molecular targeted therapies such as anti-vascular endothelial growth factor (anti-VEGF) and anti-epidermal growth factor (anti-EGFR). Bevacizumab, aflibercept and ramucirumab which belong to the first category, have been used for many years in clinical practice, achieving improvements in progression- free survival and overall survival in many phase III trials. These agents act by blocking the growth of the tumor vascular bed via the inhibition of neoangiogenesis. This review summarizes all available data in the literature on bevacizumab, aflibercept, and ramucirumab and describes their use in the continuum of care of mCRC.

참고문헌 (62)

  1. Ortega J, "Current progress in targeted therapy for colorectal cancer", Cancer Control, 17, pp.7~15 (2010)
  2. Jemal A, "Cancer statistics, 2008", CA Cancer J Clin, 58, pp.71~96 (2008)
  3. Hurwitz H, "Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer", N Engl J Med, 350, pp.2335~2342 (2004)
  4. Karamysheva AF, "Mechanisms of angiogenesis", Biochemistry(Mosc), 73, pp.751~762 (2008)
  5. Döme B, "Alternative vascularization mechanisms in cancer : pathology and therapeutic implications", Am J Pathol, 170, pp.1~15 (2007)
  6. Folkman J, "Is angiogenesis an organizing principle in biology and medicine?", J Pediatr Surg, 42, pp.1~11 (2007)
  7. Van Cutsem E, "O-0024 Intravenous(IV)aflibercept versus placebo in combination with irinotecan", 5-FU(FOLFIRI)for secondline treatment of metastatic colorectal cancer(MCRC) : results of a multinational phase III trial(EFC10262-VELOUR), 2011, pp.22(Suppl 5), v18~
  8. Folkman J, "Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis", N Engl J Med, 333, pp.1757~1763 (1995)
  9. Zetter BR, "Angiogenesis and tumor metastasis", Annu Rev Med, 49, pp.407~424 (1998)
  10. Bergers G, "Tumorigenesis and the angiogenic switch", Nat Rev Cancer, 3, pp.401~410 (2003)
  11. Hicklin DJ, "Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis", J Clin Oncol, 23, pp.1011~1027 (2005)
  12. Ferrara N., "Vascular endothelial growth factor as a target for anticancer therapy", Oncologist, 9(Suppl 1), pp.2~10 (2004)
  13. Ferrara N, "Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer", Nat Rev Drug Discov, 3, pp.391~400 (2004)
  14. Carrato A, "Anti-VEGF therapy : a new approach to colorectal cancer therapy", Expert Rev Anticancer Ther, 6, pp.1385~1396 (2006)
  15. Ishigami SI, "Predictive value of vascular endothelial growth factor(VEGF)in metastasis and prognosis of human colorectal cancer", Br J Cancer, 78, pp.1379~1384 (1998)
  16. Wong MP, "Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression", Int J Cancer, 81, pp.845~850 (1999)
  17. Martins SF, "Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies", World J Clin Oncol, 2, pp.272~280 (2011)
  18. Jain RK, "Normalization of tumor vasculature : an emerging concept in antiangiogenic therapy", Science, 307, pp.58~62 (2005)
  19. Kerbel RS, "Antiangiogenic therapy : a universal chemosensitization strategy for cancer?", Science, 312, pp.1171~1175 (2006)
  20. Shaked Y, "Rapid chemotherapy-induced acute endothelial progenitor cell mobilization : implications for antiangiogenic drugs as chemosensitizing agents", Cancer Cell, 14, pp.263~273 (2008)
  21. Gordon MS, "Phase I safety and pharmacokinetic study of recombinant human antivascular endothelial growth factor in patients with advanced cancer", J Clin Oncol, 19, pp.843~850 (2001)
  22. Scheithauer W, "Bevacizumab plus oxaliplatin-based regimens for the treatment of colorectal cancer", Onkologie, 32, pp.431~439 (2009)
  23. Fuchs CS, "Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer : results from the BICC-C Study", J Clin Oncol, 25, pp.4779~4786 (2007)
  24. Fuchs CS, "Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer : updated results from the BICC-C study", J Clin Oncol, 26, pp.689~690 (2008)
  25. Saltz LB, "Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer : a randomized phase III study", J Clin Oncol, 26, pp.2013~2019 (2008)
  26. Giantonio BJ, "Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200", J Clin Oncol, 25, pp.1539~1544 (2007)
  27. Kabbinavar FF, "Combined analysis of efficacy : the addition of bevacizumab to fluorouracil", leucovorin improves survival for patients with metastatic colorectal cancer, 2005, pp.23, 3706~3712
  28. Hurwitz H, "Bevacizumab combined with standard fluoropyrimidinebased chemotherapy regimens to treat colorectal cancer", Oncology, 69(Suppl 3), pp.17~24 (2005)
  29. Chu E, "An update on the current and emerging targeted agents in metastatic colorectal cancer", Clin Colorectal Cancer, 11, pp.1~13 (2012)
  30. Kozloff M, "Clinical outcomes associated with bevacizumabcontaining treatment of metastatic colorectal cancer: the BRiTE observational cohort study", Oncologist, 14, pp.862~870 (2009)
  31. Bennouna J, "Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial", Lancet Oncol, 14, pp.29~37 (2013)
  32. Shaheen RM, "Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors", Br J Cancer, 85, pp.584~589 (2001)
  33. Ellis LM, "Epidermal growth factor receptor in tumor angiogenesis", Hematol Oncol Clin North Am, 18, pp.1007~1021 (2004)
  34. Hecht JR, "A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer", J Clin Oncol, 27, pp.672~680 (2009)
  35. Tol J, "Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer", N Engl J Med, 363, pp.563~572 (2010)
  36. Saltz L, "Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil", leucovorin vs. FOLFOXbevacizumab in colorectal cancer, 2012, pp.11, 101~111
  37. De Gramont A, "AVANT: results from a randomized, three-arm multinational phase III study to investigate bevacizumab with either XELOX or FOLFOX4 versus FOLFOX4alone as adjuvant treatment for colon cancer", J Clin Oncol, 29(4 Suppl), pp.362~ (2011)
  38. Wolmark N, "A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP protocol C-08", J Clin Oncol, 27(18 Suppl), pp.LBA4~ (2009)
  39. Holash J, "VEGFTrap : a VEGF blocker with potent antitumor effects", Proc Natl Acad Sci U S A, 99, pp.11393~11398 (2002)
  40. Stewart MW, "Aflibercept(VEGF-TRAP) : the next anti-VEGF drug", Inflamm Allergy Drug Targets, 10, pp.497~508 (2011)
  41. Cursiefen C, "VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment", J Clin Invest, 113, pp.1040~1050 (2004)
  42. Kim ES, "Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma", Proc Natl Acad Sci U S A, 99, pp.11399~11404 (2002)
  43. Teng LS, "Clinical applications of VEGFtrap(aflibercept)in cancer treatment", J Chin Med Assoc, 73, pp.449~456 (2010)
  44. Lal D, "Aflibercept exerts antivascular effects and enhances levels of anthracycline chemotherapy in vivo in human acute myeloid leukemia models", Mol Cancer Ther, 9, pp.2737~2751 (2010)
  45. Hu L, "Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model", Clin Cancer Res, 11(19 Pt 1), pp.6966~6971 (2005)
  46. Lockhart AC, "Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors", J Clin Oncol, 28, pp.207~214 (2010)
  47. Tew WP, "Phase 1study of aflibercept administered subcutaneously to patients with advanced solid tumors", Clin Cancer Res, 16, pp.358~366 (2010)
  48. de Groot JF, "Phase II study of aflibercept in recurrent malignant glioma : a North American Brain Tumor Consortium study", J Clin Oncol, 29, pp.2689~2695 (2011)
  49. Jin K, "Aflibercept(VEGF Trap) : one more double-edged sword of anti-VEGF therapy for cancer?", Clin Transl Oncol, 12, pp.526~532 (2010)
  50. Rudge JS, "VEGF trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade", Proc Natl Acad Sci U S A, 104, pp.18363~18370 (2007)
  51. Reichert JM, "Antibody-based therapeutics to watch in 2011", MAbs, 3, pp.76~99 (2011)
  52. "Two year results of phase 3 studies with EYLEATM (aflibercept) injection in wet AMD show sustained improvement in visual acuity" (2011)[URL]
  53. Tabernero J, "Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study", Lancet Oncol, 16, pp.499~508 (2015)
  54. Grothey A, "Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer : results from a large observational cohort study(BRiTE)", J Clin Oncol, 26, pp.5326~5334 (2008)
  55. Mass RD, "Clinical benefit from bevacizumab(BV)in responding(R)and non-responding(NR)patients(pts)with metastatic colorectal cancer(mCRC)", J Clin Oncol, 23(16 Suppl), pp.3514~ (2005)
  56. Kopetz S, "Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer : efficacy and circulating angiogenic biomarkers associated with therapeutic resistance", J Clin Oncol, 28, pp.453~459 (2010)
  57. "Combination chemotherapy and bevacizumab with or without erlotinib in treating patients with metastatic colorectal cancer that cannot be removed by surgery" (2005)[URL]
  58. Chaplin DJ, "Current development status of smallmolecule vascular disrupting agents", Curr Opin Investig Drugs, 7, pp.522~528 (2006)
  59. Kerbel RS, "The anti-angiogenic basis of metronomic chemotherapy", Nat Rev Cancer, 4, pp.423~436 (2004)
  60. Pohl M, "Biomarkers of anti-angiogenic therapy in metastatic colorectal cancer(mCRC) : original data and review of the literature", Z Gastroenterol, 49, pp.1398~1406 (2011)
  61. Loupakis F, "Targeting vascular endothelial growth factor pathway in first-line treatment of metastatic colorectal cancer : state-of-the-art and future perspectives in clinical and molecular selection of patients", Curr Cancer Drug Targets, 10, pp.37~45 (2010)
  62. Matsusaka S, "Circulating endothelial cells predict for response to bevacizumab-based chemotherapy in metastatic colorectal cancer", Cancer Chemother Pharmacol, 68, pp.763~768 (2011)

관련 논문AI추천

Anti-angiogenic Therapy in Patients with Advanced Gastric and Gastroesophageal Junction Cancer: A Systematic Review강윤구, 김종석, 류민희, 오도연, Kun-Huei Yeh, Li-Tzong Chen, Mauro Orlando, Rebecca Cheng, Roberto Carlesi, Winnie Yeo대한암학회 · Cancer Research and Treatment2017 · 제49권 제4호Dose KRAS Mutation Status Affect on the Effect of VEGF Therapy in Metastatic Colon Cancer Patients?김승태, 김열홍, 박경화, 신상원대한암학회 · Cancer Research and Treatment2014 · 제46권 제1호Optimal Maintenance Strategy for First-Line Oxaliplatin-Containing Therapy with or without Bevacizumab in Patients with Metastatic Colorectal Cancer: A Meta-AnalysisAkinori Sugaya, Ichinosuke Hyodo, Masahiko Gosho, Takeshi Yamada, Toshikazu Moriwaki, Yoshiyuki Yamamoto대한암학회 · Cancer Research and Treatment2021 · 제53권 제3호Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-AnalysisAlfredo Falcone, Beatrice Borelli, Carlotta Antoniotti, Chiara Baratelli, Chiara Cremolini, Cristina Sonetto, Federica Marmorino, Federico Nichetti, Filippo de Braud, Filippo Pietrantonio, Fotios Loupakis, Lisa Salvatore, Marco Tampellini, Maria Di Bartolomeo, Massimo Di Maio, Paolo Bironzo, Rosa Berenato대한암학회 · Cancer Research and Treatment2017 · 제49권 제3호Evaluating the recent developments in palliative chemotherapy for metastatic colorectal cancer배상병, 백선경, 이규택, 이상철대한내과학회 · The Korean Journal of Internal Medicine2019 · 제34권 제6호Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Surrogate Biomarker for Bevacizumab in Colorectal Cancer Liver Metastasis: A Single-Arm, Exploratory Trial김명진, 김여은, 박미숙, 신상준, 안중배, Bio Joo대한암학회 · Cancer Research and Treatment2016 · 제48권 제4호

이 간행물의 다른 논문 (9건)