본문 바로가기
KERD
논문KCI 등재

Evaluating the recent developments in palliative chemotherapy for metastatic colorectal cancer

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

The incidence of colorectal cancer (CRC) has increased. CRC is the third most common cancer and the fourth most common cause of cancer-related deaths in Korea. Palliative chemotherapy can be used to shrink tumors and ease symptoms caused by the cancer when cure is not possible. It is important to identify chemotherapeutic agents that can be used to effectively treat metastatic CRC (mCRC) and thus improve the survival and quality of life of patients with mCRC. This review aimed to evaluate the recent developments in palliative chemotherapy for mCRC and the biological or targeted agents used based on genetic alterations.

Abstract

The incidence of colorectal cancer (CRC) has increased. CRC is the third most common cancer and the fourth most common cause of cancer-related deaths in Korea. Palliative chemotherapy can be used to shrink tumors and ease symptoms caused by the cancer when cure is not possible. It is important to identify chemotherapeutic agents that can be used to effectively treat metastatic CRC (mCRC) and thus improve the survival and quality of life of patients with mCRC. This review aimed to evaluate the recent developments in palliative chemotherapy for mCRC and the biological or targeted agents used based on genetic alterations.

참고문헌 (66)

  1. 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012", Cancer Research and Treatment, 47(2), pp.127~141 (2015), 대한암학회[DOI]
  2. Watanabe T, "Japanese Society for Cancer of the Colon and Rectum(JSCCR)guidelines 2010 for the treatment of colorectal cancer", Int J Clin Oncol, 17, pp.1~29 (2012)
  3. Andre T, "Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer", N Engl J Med, 350, pp.2343~2351 (2004)
  4. Seo SI, "Comparison of recurrence patterns between ≤5 years and >5 years after curative operations in colorectal cancer patients", J Surg Oncol, 108, pp.9~13 (2013)
  5. Sobrero AF, "Fluorouracil in colorectal cancer : a tale of two drugs : implications for biochemical modulation", J Clin Oncol, 15, pp.368~381 (1997)
  6. "Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project", J Clin Oncol, 10, pp.896~903 (1992)
  7. de Gramont A, "Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer : a French intergroup study", J Clin Oncol, 15, pp.808~815 (1997)
  8. de Gramont A, "Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer", J Clin Oncol, 18, pp.2938~2947 (2000)
  9. Douillard JY, "Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer : a multicentre randomised trial", Lancet, 355, pp.1041~1047 (2000)
  10. Tournigand C, "FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer : a randomized GERCOR study", J Clin Oncol, 22, pp.229~237 (2004)
  11. Hoff PM, "Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer : results of a randomized phase III study", J Clin Oncol, 19, pp.2282~2292 (2001)
  12. Van Cutsem E, "Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer : results of a large phase III study", J Clin Oncol, 19, pp.4097~4106 (2001)
  13. Kwakman JJM, "Randomized phase III trial of S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer : SALTO study by the Dutch Colorectal Cancer Group", Ann Oncol, 28, pp.1288~1293 (2017)
  14. Mayer RJ, "Randomized trial of TAS-102 for refractory metastatic colorectal cancer", N Engl J Med, 372, pp.1909~1919 (2015)
  15. Cassidy J, "Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil", folinic acid plus oxaliplatin as firstline therapy for metastatic colorectal cancer, 2008, pp.26, 2006~2012
  16. Falcone A, "Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan(FOLFOXIRI)compared with infusional fluorouracil, leucovorin, and irinotecan(FOLFIRI)as first-line treatment for metastatic colorectal cancer : the Gruppo Oncologico Nord Ovest", J Clin Oncol, 25, pp.1670~1676 (2007)
  17. Hurwitz H, "Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer", N Engl J Med, 350, pp.2335~2342 (2004)
  18. Passardi A, "Effectiveness of bevacizumab added to standard chemotherapy in metastatic colorectal cancer : final results for first-line treatment from the ITACa randomized clinical trial", Ann Oncol, 26, pp.1201~1207 (2015)
  19. Stathopoulos GP, "Treatment of colorectal cancer with and without bevacizumab : a phase III study", Oncology, 78, pp.376~381 (2010)
  20. Cunningham D, "Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer(AVEX) : an open-label, randomised phase 3 trial", Lancet Oncol, 14, pp.1077~1085 (2013)
  21. Saltz LB, "Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer : a randomized phase III study", J Clin Oncol, 26, pp.2013~2019 (2008)
  22. Tebbutt NC, "Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer : results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study", J Clin Oncol, 28, pp.3191~3198 (2010)
  23. Loupakis F, "Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer", N Engl J Med, 371, pp.1609~1618 (2014)
  24. Giantonio BJ, "Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin(FOLFOX4)for previously treated metastatic colorectal cancer : results from the Eastern Cooperative Oncology Group Study E3200", J Clin Oncol, 25, pp.1539~1544 (2007)
  25. Bennouna J, "Continuation of bevacizumab after first progression in metastatic colorectal cancer(ML18147) : a randomised phase 3 trial", Lancet Oncol, 14, pp.29~37 (2013)
  26. Van Cutsem E, "Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen", J Clin Oncol, 30, pp.3499~3506 (2012)
  27. Tabernero J, "Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine(RAISE) : a randomised, double-blind, multicentre, phase 3 study", Lancet Oncol, 16, pp.499~508 (2015)
  28. Grothey A, "Regorafenib monotherapy for previously treated metastatic colorectal cancer(CORRECT) : an international, multicentre, randomised, placebo-controlled, phase 3 trial", Lancet, 381, pp.303~312 (2013)
  29. Jonker DJ, "Cetuximab for the treatment of colorectal cancer", N Engl J Med, 357, pp.2040~2048 (2007)
  30. Karapetis CS, "K-ras mutations and benefit from cetuximab in advanced colorectal cancer", N Engl J Med, 359, pp.1757~1765 (2008)
  31. Bokemeyer C, "FOLFOX4plus cetuximab treatment and RAS mutations in colorectal cancer", Eur J Cancer, 51, pp.1243~1252 (2015)
  32. Douillard JY, "Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer", N Engl J Med, 369, pp.1023~1034 (2013)
  33. Van Cutsem E, "Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer", J Clin Oncol, 33, pp.692~700 (2015)
  34. Misale S, "Resistance to anti-EGFR therapy in colorectal cancer : from heterogeneity to convergent evolution", Cancer Discov, 4, pp.1269~1280 (2014)
  35. Maughan TS, "Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer : results of the randomised phase 3 MRC COIN trial", Lancet, 377, pp.2103~2114 (2011)
  36. Tveit KM, "Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin(Nordic FLOX)versus FLOX alone in first-line treatment of metastatic colorectal cancer : the NORDIC-VII study", J Clin Oncol, 30, pp.1755~1762 (2012)
  37. Van Cutsem E, "Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer", N Engl J Med, 360, pp.1408~1417 (2009)
  38. Van Cutsem E, "Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer : updated analysis of overall survival according to tumor KRAS and BRAF mutation status", J Clin Oncol, 29, pp.2011~2019 (2011)
  39. Douillard JY, "Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin(FOLFOX4)versus FOLFOX4alone as first-line treatment in patients with previously untreated metastatic colorectal cancer : the PRIME study", J Clin Oncol, 28, pp.4697~4705 (2010)
  40. Stintzing S, "FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab for metastatic colorectal cancer(FIRE-3) : a post-hoc analysis of tumour dynamics in the final RAS wild-type subgroup of this randomised open-label phase 3 trial", Lancet Oncol, 17, pp.1426~1434 (2016)
  41. Schwartzberg LS, "PEAK : a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin(mFOLFOX6)or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer", J Clin Oncol, 32, pp.2240~2247 (2014)
  42. Venook AP, "Effect of first-line chemotherapy combined with cetuximab or bevacizumab on overall survival in patients with KRAS wild-type advanced or metastatic colorectal cancer : a randomized clinical trial", JAMA, 317, pp.2392~2401 (2017)
  43. Arnold D, "Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials", Ann Oncol, 28, pp.1713~1729 (2017)
  44. Tejpar S, "Prognostic and predictive relevance of primary tumor location in patients with RAS wild-type metastatic colorectal cancer : retrospective analyses of the CRYSTAL and FIRE-3 trials", JAMA Oncol, 3, pp.194~201 (2017)
  45. Morgan CT, "Systemic chemotherapy for resectable hepatic colorectal metastases: adjuvant, neoadjuvant, or not at all?", Curr Surg Rep, 2, pp.52~ (2014)
  46. Portier G, "Multicenter randomized trial of adjuvant fluorouracil and folinic acid compared with surgery alone after resection of colorectal liver metastases : FFCD ACHBTH AURC 9002 trial", J Clin Oncol, 24, pp.4976~4982 (2006)
  47. Mitry E, "Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer : a pooled analysis of two randomized trials", J Clin Oncol, 26, pp.4906~4911 (2008)
  48. Primrose J, "Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis : the New EPOC randomised controlled trial", Lancet Oncol, 15, pp.601~611 (2014)
  49. Chun YS, "Management of chemotherapy-associated hepatotoxicity in colorectal liver metastases", Lancet Oncol, 10, pp.278~286 (2009)
  50. Karoui M, "Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases", Ann Surg, 243, pp.1~7 (2006)
  51. Gruenberger T, "Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer : the OLIVIA multinational randomised phase II trial", Ann Oncol, 26, pp.702~708 (2015)
  52. Blazer DG 3rd, "Pathologic response to preoperative chemotherapy : a new outcome end point after resection of hepatic colorectal metastases", J Clin Oncol, 26, pp.5344~5351 (2008)
  53. Folprecht G, "Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX", cetuximab or FOLFIRI, Ann Oncol, pp.2014, 25[DOI]
  54. Ye LC, "Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases", J Clin Oncol, 31, pp.1931~1938 (2013)
  55. Tournigand C, "OPTIMOX1 : a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer : a GERCOR study", J Clin Oncol, 24, pp.394~400 (2006)
  56. Simkens LH, "Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer(CAIRO3) : a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group", Lancet, 385, pp.1843~1852 (2015)
  57. Hegewisch-Becker S, "Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer(AIO 0207) : a randomised, non-inferiority, open-label, phase 3 trial", Lancet Oncol, 16, pp.1355~1369 (2015)
  58. Cancer Genome Atlas Network, "Comprehensive molecular characterization of human colon and rectal cancer", Nature, 487, pp.330~337 (2012)
  59. Sanz-Garcia E, "BRAF mutant colorectal cancer : prognosis, treatment, and new perspectives", Ann Oncol, 28, pp.2648~2657 (2017)
  60. Van Cutsem E, "ESMO consensus guidelines for the management of patients with metastatic colorectal cancer", Ann Oncol, 27, pp.1386~1422 (2016)
  61. Kopetz S, "Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer", J Clin Oncol, 33, pp.4032~4038 (2015)
  62. Greally M, "HER2 : an emerging target in colorectal cancer", Curr Probl Cancer, 42, pp.560~571 (2018)
  63. Sartore-Bianchi A, "Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12", 13 wild-type, HER2-positive metastatic colorectal cancer(HERACLES) : a proofof-concept, multicentre, open-label, phase 2 trial, 2016, pp.17, 738~746
  64. Le DT, "PD-1 blockade in tumors with mismatch-repair deficiency", N Engl J Med, 372, pp.2509~2520 (2015)
  65. Overman MJ, "Durable clinical benefit with nivolumab plus ipilimumab in DNA mismatch repair-deficient", microsatellite instability-high metastatic colorectal cancer, 2018, pp.36, 773~779
  66. Lee JJ, "Recent advances in the clinical development of immune checkpoint blockade therapy for mismatch repair proficient(pMMR)", non-MSI-H metastatic colorectal cancer, 2018, pp.17, 258~273

관련 논문AI추천

대장암에 대한 항암화학요법 사용평가김원규, 박윤희, 방은미, 임금숙한국병원약사회 · 병원약사회지2010 · 제27권 제2호Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer강병욱, 고윤호, 구동회, 김종광, 김진원, 김태유, 백진호, 송은기, 송홍석, 오소연, 이경희, 이근욱, 장대영, 정익주, 조하나, 홍영선대한암학회 · Cancer Research and Treatment2019 · 제51권 제1호Optimal Maintenance Strategy for First-Line Oxaliplatin-Containing Therapy with or without Bevacizumab in Patients with Metastatic Colorectal Cancer: A Meta-AnalysisAkinori Sugaya, Ichinosuke Hyodo, Masahiko Gosho, Takeshi Yamada, Toshikazu Moriwaki, Yoshiyuki Yamamoto대한암학회 · Cancer Research and Treatment2021 · 제53권 제3호대장암의 표적치료이경희영남대학교 의과대학 · Journal of Yeungnam Medical Science2006 · 제23권 제2호A Retrospective Study of First-Line Combination Chemotherapy in Advanced Colorectal Cancer: A Korean Single-Center Experience강원기, 박건우, 박세훈, 박영석, 박준오, 이순일, 이지연, 임도형, 임호영대한암학회 · Cancer Research and Treatment2011 · 제43권 제2호Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-AnalysisAlfredo Falcone, Beatrice Borelli, Carlotta Antoniotti, Chiara Baratelli, Chiara Cremolini, Cristina Sonetto, Federica Marmorino, Federico Nichetti, Filippo de Braud, Filippo Pietrantonio, Fotios Loupakis, Lisa Salvatore, Marco Tampellini, Maria Di Bartolomeo, Massimo Di Maio, Paolo Bironzo, Rosa Berenato대한암학회 · Cancer Research and Treatment2017 · 제49권 제3호

이 간행물의 다른 논문 (26건)