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Thyroxine (T4) Autoantibody Interference of Free T4 Concentration Measurement in a Patient With Hashimoto’s Thyroiditis

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Dear Editor, Interactions of thyroid hormone autoantibodies (THAAs) with thyroxine (T4) or triiodothyronine (T3) are less common than interactions of antibodies to thyroglobulin, microsomal thyroid peroxidase, and thyroid-stimulating hormone (TSH) receptor. Nevertheless, these THAAs have been reported to cause spurious thyroid function test (TFT) results, indicating that TFT results do not always accurately reflect the clinical status of the patient and are not necessarily consistent [1, 2].

Abstract

Dear Editor, Interactions of thyroid hormone autoantibodies (THAAs) with thyroxine (T4) or triiodothyronine (T3) are less common than interactions of antibodies to thyroglobulin, microsomal thyroid peroxidase, and thyroid-stimulating hormone (TSH) receptor. Nevertheless, these THAAs have been reported to cause spurious thyroid function test (TFT) results, indicating that TFT results do not always accurately reflect the clinical status of the patient and are not necessarily consistent [1, 2].

참고문헌 (7)

  1. Despres N, "Antibody interference in thyroid assays: a potential for clinical misinformation", Clin Chem, 44, pp.440~454 (1998)
  2. Zouwail SA, "Influence of thyroid hormone autoantibodies on 7 thyroid hormone assays", Clin Chem, 54, pp.927~928 (2008)
  3. van der Watt G, "Euthyroid patient with elevated serum free thyroxine", Clin Chem, 54, pp.1239~1241 (2008)
  4. Ismail AA, "Wrong biochemistry results", BMJ, 323, pp.705~706 (2001)
  5. Chung YE, "A Case of Hashimotos Thyroiditis with Anti-Triiodothyronine Autoantibody", J Kore Table an Soc Endocrinol, 16, pp.245~251 (2001)
  6. 박재호, "삼요오드티로닌 자가항체가 동반된 일차성 갑상선기능저하증 1예", Endocrinology and Metabolism, 21(5), pp.428~432 (2006), 대한내분비학회
  7. Sakata S, "Prevalence of thyroid hormone autoantibodies in healthy subjects", Clin Endocrinol (Oxf), 41, pp.365~370 (1994)

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