Spurious Thyroid Function Test Results due to Biotin Interference: a Report of Three Cases and a Literature Review
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Biotin (vitamin B7) is a water-soluble vitamin used as a co-enzyme for carboxylases essential for humanmetabolism. The high affinity to streptavidin makes biotin an important substance in immunoassays. Excessivebiotin intake due to over-the counter supplements has become problematic because of the effects on laboratorytest results. There have been no reports of biotin-induced thyroid immunoassay interference in Korea. We reportthree patients with papillary thyroid cancer who showed false thyrotoxicosis on follow-up laboratory examinationswith a literature review. The patients’ medical history should be thoroughly questioned and patients should beinformed to curtail consuming biotin before laboratory tests to avoid assay interference. Non-biotinylated assayscan be considered if it is impossible to withhold the supplements. These methods will prevent physicians frommaking incorrect decisions that could result in an inappropriate treatment for their patients.
Abstract
Biotin (vitamin B7) is a water-soluble vitamin used as a co-enzyme for carboxylases essential for humanmetabolism. The high affinity to streptavidin makes biotin an important substance in immunoassays. Excessivebiotin intake due to over-the counter supplements has become problematic because of the effects on laboratorytest results. There have been no reports of biotin-induced thyroid immunoassay interference in Korea. We reportthree patients with papillary thyroid cancer who showed false thyrotoxicosis on follow-up laboratory examinationswith a literature review. The patients’ medical history should be thoroughly questioned and patients should beinformed to curtail consuming biotin before laboratory tests to avoid assay interference. Non-biotinylated assayscan be considered if it is impossible to withhold the supplements. These methods will prevent physicians frommaking incorrect decisions that could result in an inappropriate treatment for their patients.
참고문헌 (19)
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