Extended Red Blood Cell Genotyping to Investigate Immunohematology Problems
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초록
Red blood cell (RBC) genotyping is recommended to limit alloimmunization in patients with sickle cell disease or thalassemia [1]. RBC genotyping can resolve the serologic weak D phenotype and inconclusive RhD typing in obstetrics and identify the RBC phenotype in patients with autoantibodies or a positive direct antiglobulin test (DAT) [2]. DNA-based RBC typing has better accuracy and provides more information on RBC antigens than typical phenotyping [1]. We report a challenging case of a pregnant patient in whom a lack of compatible RBCs, based on RBC genotyping, suggested the presence of anti-Dib and anti-E specificities. To our knowledge, extended RBC genotyping was used to obtain compatible RBC units for the first time in Korea.
Abstract
Red blood cell (RBC) genotyping is recommended to limit alloimmunization in patients with sickle cell disease or thalassemia [1]. RBC genotyping can resolve the serologic weak D phenotype and inconclusive RhD typing in obstetrics and identify the RBC phenotype in patients with autoantibodies or a positive direct antiglobulin test (DAT) [2]. DNA-based RBC typing has better accuracy and provides more information on RBC antigens than typical phenotyping [1]. We report a challenging case of a pregnant patient in whom a lack of compatible RBCs, based on RBC genotyping, suggested the presence of anti-Dib and anti-E specificities. To our knowledge, extended RBC genotyping was used to obtain compatible RBC units for the first time in Korea.
참고문헌 (10)
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