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Antioxidant activities of hot water extract of Syneilesis palmata root and aerial part

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주제분류식품과학

초록

This study was performed in order to investigate the antioxidant properties of hot water extract from the root and aerial part of the Syneilesis palmata in respect to its potential use as food, cosmetics material, or medicinal resource. The results showed that the S. palmata root hot water extract (RHW) possessed a higher content of total flavonoid compounds (4.58 mg/g) and total polyphenol compounds (59.11 mg/g). The SOD-like activities of the RHW and APHW were 23.74% and 21.61%, respectively, at a concentration 2,000 ug/mL. In the nitrite scavenging ability of a 2,000 μg/mL concentration, the RHW showed 63.06% (pH 1.2) and 47.16% (pH 3.0). The IC50 values of the nitrite scavenging abilities were 99.93 μg/mL (ascorbic acid), 1,150.85 μg/mL (RHW), and 1,610.25 μg/mL (APHW). The IC50 values of DPPH free radical scavenging abilities were 99.87 μg/mL (RHW) and 118.29 μg/mL (APHW). The inhibition values (IC50) of xanthine oxidase were 139.62 μg/mL (RHW) and 111.11 μg/mL (APHW). In all of the experiments, the S. palmata root hot water extracts have higher activities than the aerial hot water extract, except for the xanthine oxidase inhibitory activity. These results suggest that the S. palmata is a potentially useful antioxidant source for the development of functional nutraceuticals, cosmetics and medicine.

Abstract

This study was performed in order to investigate the antioxidant properties of hot water extract from the root and aerial part of the Syneilesis palmata in respect to its potential use as food, cosmetics material, or medicinal resource. The results showed that the S. palmata root hot water extract (RHW) possessed a higher content of total flavonoid compounds (4.58 mg/g) and total polyphenol compounds (59.11 mg/g). The SOD-like activities of the RHW and APHW were 23.74% and 21.61%, respectively, at a concentration 2,000 ug/mL. In the nitrite scavenging ability of a 2,000 μg/mL concentration, the RHW showed 63.06% (pH 1.2) and 47.16% (pH 3.0). The IC50 values of the nitrite scavenging abilities were 99.93 μg/mL (ascorbic acid), 1,150.85 μg/mL (RHW), and 1,610.25 μg/mL (APHW). The IC50 values of DPPH free radical scavenging abilities were 99.87 μg/mL (RHW) and 118.29 μg/mL (APHW). The inhibition values (IC50) of xanthine oxidase were 139.62 μg/mL (RHW) and 111.11 μg/mL (APHW). In all of the experiments, the S. palmata root hot water extracts have higher activities than the aerial hot water extract, except for the xanthine oxidase inhibitory activity. These results suggest that the S. palmata is a potentially useful antioxidant source for the development of functional nutraceuticals, cosmetics and medicine.

참고문헌 (44)

  1. Torel J, "Antioxidant activity of flavonoids and reactivity with peroxy radical", Phytochem, 2, pp.383~385 (1986)
  2. Halliwell B, "Oxygen toxicity, oxygen radicals, transition metals and disease", Biochem J, 219, pp.1~14 (1984)
  3. Lipworth L, "Olive oil and human cancer; an assessment of evidence", Prev Med, 26, pp.181~190 (1997)
  4. Bashan N, "Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species", Physiol Rev, 89, pp.27~71 (2009)
  5. Diplock AT, "Functional food science and defence against reactive oxidative species", Brit J Nutr, 80, pp.77~112 (1998)
  6. Hu FB, "Dietary pattern analysis: a new direction in nutritional epidemiology", Curr Opin Lipidol, 13, pp.3~9 (2000)
  7. Lee YN, "Flora of Korea 3th edition" (1998), Kyohaksa
  8. An DK, "Illustrated book of Korean medicinal herbs", pp.347~ (1998), Kyohaksa
  9. Kim H, "Medicinal efficacy of plants utilized as temple food in traditional Korean Buddhism", J Ethnopharm, 104, pp.32~46 (2006)
  10. Kuroda C, "New 14-oxofuranoeremophilanes and related sesquiterpenes from Syneilesis palmata(Thunb. )Maxim", Chem Lett, pp.1313~1316 (1978)
  11. Manabu H, "Syneilesine, a new pyrrolizine alkaloid from Syneilesis palmata", Tetrahedron Lett, 41, pp.3657~3660 (1974)
  12. Bolhmann F, "Terpeneglucoside aus Syneilesis aconitifolia", Phytochem, 16, pp.1057~1059 (1977)
  13. Bolhmann F, "Neue furaneremophilane und andere sesquiterpene aus vertretern gattung Europs", Phytochem, 17, pp.1135~1153 (1978)
  14. 이양숙, "우산나물(Syneilesis palmata)의 성분 분석", 한국식품저장유통학회지, 16(3), pp.412~418 (2009), 한국식품저장유통학회
  15. 이양숙, "우산나물(Syneilesis palmata) 추출물의 항산화 활성", 한국식품영양과학회지, 38(11), pp.1471~1477 (2009), 한국식품영양과학회
  16. Kyu Ha Lee, "Sesquiterpenes from Syneilesis palmata and Their Cytotoxicity Against Human Cancer Cell Lines In Vitro", Archives of Pharmacal Research, 28(3), pp.280~284 (2005), 대한약학회
  17. 권정숙, "식용 및 약용 산채류로부터 트롬빈 저해물질의 탐색", 생명과학회지, 14(3), pp.509~513 (2004), 한국생명과학회
  18. Nieva Moreno MI, "Comparison of the free radical-scavenging activity of propolis from several regions of Argentina", J Ethnopharmacol, 71, pp.109~114 (2000)
  19. AOAC, "Official method of analysis", pp.21~22 (2005), Association of official analytical Chemists
  20. Marklund S, "Involvement of superoxide amino radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase", Eur J Biochem, 47, pp.468~474 (1975)
  21. Kato H, "Inhibition of nitrosamine formation by nondialyzable melanoidins", Agric Biol Chem, 51, pp.1333~1338 (1987)
  22. Blois MS, "Antioxidant determination by the use of a stable free radical", Nature, 181, pp.1199~1200 (1958)
  23. Stirpe F, "The regulation of rat liver xanthine oxidase", J Biol Chem, 244, pp.3855~3861 (1969)
  24. Shahidi F, "Phenolic antioxidant", Crit Rev Food Sci, 32, pp.67~103 (1992)
  25. Velioglu YS, "Antioxidant activity and total phenolics in selected fruits, vegetables. and grain products", J Agri Food Chem, 46, pp.413~417 (1998)
  26. Cai Y, "Antioxidant activity and phenolic compounds of 112 Chinese medicinal plants associated with anticancer", Life Sci, 74, pp.2157~2184 (2004)
  27. Matkowski A, "Plant in vitro culture for the production of antioxidants", Rev Biotech Adv, 26, pp.548~560 (2008)
  28. Vinson JA, "Determination of quantify and quality of polyphenol antioxidants in foods and beverages", Method Enzymol, 335, pp.103~114 (2001)
  29. Duan X, "Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention", Molecules, 12, pp.759~771 (2007)
  30. Conner EM, "Inflammation, free radicals, and antioxidants", Nutrition, 12, pp.274~280 (1996)
  31. Zielinski H, "The effect of germination process on the superoxide dismutase-like activity and thiamine, riboflavin and mineral contents of rapeseeds", Food Chem, 99, pp.516~521 (2006)
  32. Fridovich I, "Superoxide anion radical(O2-), superoxide dismutases, and related matters", J Biol Chem, 272, pp.18515~18517 (1997)
  33. 신승렬, "한방재료 열수 추출물의 항산화 효과", 한국식품영양과학회지, 35(2), pp.187~191 (2006), 한국식품영양과학회
  34. Bartsch H, "Relevance of nitrosamines to human cancer", Carcinogenesis, 5, pp.1381~1393 (1984)
  35. Mirivish SS, "Ascorbate nitrite reaction: Possible means of the formation of carcinogenic N-nitroso compounds", Science, 177, pp.65~67 (1972)
  36. Yokozawa T, "Study on the inhibitory effect of tannins and flavonoids against the 1, 1-diphenyl-2-picrylhydrazyl radical", Biochem Pharmacol, 56, pp.213~222 (1998)
  37. Kang YH, "The nitrite scavenging and electron donating ability of phenolic compounds", Korean J Food Sci Technol, 28, pp.232~239 (1996)
  38. Stroch J, "Amplifies chemiluminescence of lucigenin for determination of superoxide anion production by NADPH oxidase and xanthine oxidase", Analytical Biochem, 169, pp.262~266 (1988)
  39. Chiang HC, "Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa(Hook)Tryon", J Enzyme Inhib, 8, pp.61~71 (1994)
  40. Borges F, "Progress towards the discovery of xanthine oxidase inhibitors", Cur Med Chem, 9, pp.195~217 (2002)
  41. Cos P, "Structure activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and super oxide scavengers", J Nat Prod, 61, pp.71~76 (1998)
  42. Adkins WK, "Role of xanthine oxidase and neutrophils in ischemia-reperfusion injury in rabbit lung", J Appl Physiol, 69, pp.2012~2019 (1990)
  43. Hande KR, "Severe allopurinol toxicity: description and guidelines for prevention in patients with renal insufficiency", Am J Med, 76, pp.47~52 (1984)
  44. Urban T, "Allopurinol hypersensitivity. A possible cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment", Rev Mal Respir, 12, pp.314~316 (1995)

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