Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The purpose of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using 18F-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region. The amyloid deposition of the whole brain region was significantly negatively correlated with immediate memory.
Abstract
The purpose of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using 18F-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region. The amyloid deposition of the whole brain region was significantly negatively correlated with immediate memory.
참고문헌 (30)
- Christensen H, "A quantitative review of cognitive deficits in depression and Alzheimer-type dementia", J Int Neuropsychol Soc, 3, pp.631~651 (1997)
- Steffens DC, "Geriatric depression and cognitive impairment", Psychol Med, 38, pp.163~175 (2008)
- Zubenko GS, "A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease", Am J Psychiatry, 160, pp.857~866 (2003)
- 김재민, "Development of a Korean Version of the Perceived Deficits Questionnaire-Depression for Patients with Major Depressive Disorder", Clinical Psychopharmacology and Neuroscience, 14(1), pp.26~32 (2016), 대한정신약물학회
- Barnes DE, "The projected effect of risk factor reduction on Alzheimer's disease prevalence", Lancet Neurol, 10, pp.819~828 (2011)
- Ownby RL, "Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis", Arch Gen Psychiatry, 63, pp.530~538 (2006)
- Panza F, "Late-life depression, mild cognitive impairment, and dementia: possible continuum?", Am J Geriatr Psychiatry, 18, pp.98~116 (2010)
- Jorm AF, "History of depression as a risk factor for dementia: an updated review", Aust N Z J Psychiatry, 35, pp.776~781 (2011)
- Butters MA, "Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B", Alzheimer Dis Assoc Disord, 22, pp.261~268 (2008)
- Nascimento KK, "Plasma and cerebrospinal fluid amyloid- levels in late-life depression: A systematic review and meta-analysis", J Psychiatr Res, 69, pp.35~41 (2015)
- Sperling RA, "Toward defining the preclinical stages ofAlzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease", Alzheimers Dement, 7, pp.280~292 (2011)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders", American Psychiatric Association, ~ (2013)
- Randolph C, "The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity", J Clin Exp Neuropsychol, 20, pp.310~319 (1998)
- Fleisher AS, "Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease", Arch Neurol, 68, pp.1404~1411 (2011)
- Tzourio-Mazoyer N, "Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain", Neuroimage, 15, pp.273~289 (2002)
- Weiner MW, "The Alzheimer's Disease Neuroimaging Initiative:a review of papers published since its inception", Alzheimers Dement, 8(1 Suppl), pp.S1~S68 (2012)
- 하일호, "Mild Cognitive Impairment (MCI): Pathogenesis and Treatments", Clinical Psychopharmacology and Neuroscience, 7(1), pp.3~8 (2009), 대한정신약물학회
- Chung JK, "Lifetime history of depression predicts increased amyloid- accumulation in patients with mild cognitive impairment", J Alzheimers Dis, 45, pp.907~919 (2015)
- Brendel M, "Alzheimer’s Disease Neuroimaging Initiative. Depressive symptoms accelerate cognitive decline in amyloidpositive MCI patients", Eur J Nucl Med Mol Imaging, 42, pp.716~724 (2015)
- Zakzanis KK, "On the nature and pattern of neurocognitive function in major depressive disorder", Neuropsychiatry Neuropsychol Behav Neurol, 11, pp.111~119 (1998)
- 우영섭, "Cognitive Deficits as a Mediator of Poor Occupational Function in Remitted Major Depressive Disorder Patients", Clinical Psychopharmacology and Neuroscience, 14(1), pp.1~16 (2016), 대한정신약물학회
- McDermott LM, "A meta-analysis of depression severity and cognitive function", J Affect Disord, 119, pp.1~18 (2009)
- Bensamoun D, "Associations between neuropsychiatric symptoms and cerebral amyloid deposition in cognitively impaired elderly people", J Alzheimers Dis, 49, pp.387~398 (2015)
- Petkus AJ, "Anxiety is associated with increased risk of dementia in older Swedish twins", Alzheimers Dement, 12, pp.399~406 (2016)
- Murray J, "FDG and amyloid PET in cognitively normal individuals at risk for late-onset Alzheimer's disease", Adv J Mol Imaging, 4, pp.15~26 (2014)
- Espinosa A, "A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved", J Alzheimers Dis, 34, pp.769~780 (2013)
- Kurth F, "A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis", Brain Struct Funct, 214, pp.519~534 (2010)
- Kirchhoff BA, "Prefrontaltemporal circuitry for episodic encoding and subsequent memory", J Neurosci, 20, pp.6173~6180 (2000)
- Sarter M, "Involvement of the amygdala in learning and memory: a critical review, with emphasis on anatomical relations", Behav Neurosci, 99, pp.342~380 (1985)
- White NM, "Mnemonic functions of the basal ganglia", Curr Opin Neurobiol, 7, pp.164~169 (1997)
