Impact of White Matter Lesions on Depression in the Patients with Alzheimer’s Disease
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
ObjectiveaaComorbid depression is common in patients with Alzheimer’s disease (AD). An increase in white matter lesions (WMLs) has been associated with depression in both elderly individuals with normal cognition and patients with Alzheimer’s disease. We investigated whether the severity and location of WMLs influence the association between WMLs and comorbid depression in AD. MethodsaaWe enrolled 93 AD patients from Seoul National University Bundang Hospital. We administered both the Mini International Neuropsychiatric Inventory (MINI) and the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K) clinical and neuropsychological battery. Subjects also underwent brain magnetic resonance imaging (MRI). We diagnosed AD according to the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association. We diagnosed depressive disorders according to the DSM-IV diagnostic criteria, and evaluated the severity of depressive symptoms using the Korean version of the Geriatric Depression Scale (GDS-K). We quantified the WML volumes from the brain MRI using a fully automated segmentation algorithm. ResultsaaThe log of the WML volume in the frontal lobe was significantly associated with depressive disorders (odds ratio=1.905, 95% CI=1.027–3.533, p=0.041), but not with the severity of depressive symptoms as measured by the GDS-K. ConclusionaaThe WML volume in the frontal lobe conferred a risk of comorbid depressive disorders in AD, which implies that comorbid depression in AD may be attributed to vascular causes.
Abstract
ObjectiveaaComorbid depression is common in patients with Alzheimer’s disease (AD). An increase in white matter lesions (WMLs) has been associated with depression in both elderly individuals with normal cognition and patients with Alzheimer’s disease. We investigated whether the severity and location of WMLs influence the association between WMLs and comorbid depression in AD. MethodsaaWe enrolled 93 AD patients from Seoul National University Bundang Hospital. We administered both the Mini International Neuropsychiatric Inventory (MINI) and the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K) clinical and neuropsychological battery. Subjects also underwent brain magnetic resonance imaging (MRI). We diagnosed AD according to the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association. We diagnosed depressive disorders according to the DSM-IV diagnostic criteria, and evaluated the severity of depressive symptoms using the Korean version of the Geriatric Depression Scale (GDS-K). We quantified the WML volumes from the brain MRI using a fully automated segmentation algorithm. ResultsaaThe log of the WML volume in the frontal lobe was significantly associated with depressive disorders (odds ratio=1.905, 95% CI=1.027–3.533, p=0.041), but not with the severity of depressive symptoms as measured by the GDS-K. ConclusionaaThe WML volume in the frontal lobe conferred a risk of comorbid depressive disorders in AD, which implies that comorbid depression in AD may be attributed to vascular causes.
참고문헌 (64)
- Schmidt R, "Neuropsychologic correlates of MRI white matter hyperintensities: a study of 150 normal volunteers", Neurology, 43, pp.2490~2494 (1993)
- O’Brien J, "A magnetic resonance imaging study of white matter lesions in depression and Alzheimer’s disease", Br J Psychiatry, 168, pp.477~485 (1996)
- Almkvist O, "White-matter hyperintensity and neuropsychological functions in dementia and healthy aging", Arch Neurol, 49, pp.626~632 (1992)
- Schmidt R, "Comparison of magnetic resonance imaging in Alzheimer’s disease, vascular dementia and normal aging", Eur Neurol, 32, pp.164~169 (1992)
- Alexopoulos GS, "‘Vascular depression’ hypothesis", Arch Gen Psychiatry, 54, pp.915~922 (1997)
- Krishnan KR, "MRI-defined vascular depression", Am J Psychiatry, 154, pp.497~501 (1997)
- Lesser IM, "Late-onset depression with white matter lesions", Psychosomatics, 34, pp.364~367 (1993)
- Longstreth WT Jr, "Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study", Stroke, 27, pp.1274~1282 (1996)
- de Leeuw FE, "Hypertension and cerebral white matter lesions in a prospective cohort study", Brain, 125, pp.765~772 (2002)
- Englund E, "Neuropathology of white matter changes in Alzheimer’s disease and vascular dementia", Dement Geriatr Cogn Disord, 9(Suppl 1), pp.6~12 (1998)
- Ogata J, "Vascular dementia: the role of changes in the vessels", Alzheimer Dis Assoc Disord, 13(Suppl 3), pp.S55~S58 (1999)
- Thomas AJ, "A neuropathological study of periventricular white matter hyperintensities in major depression", J Affect Disord, 76, pp.49~54 (2003)
- van Swieten JC, "Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces", Brain, 114(Pt 2), pp.761~774 (1991)
- Prins ND, "Cerebral white matter lesions and the risk of dementia", Arch Neurol, 61, pp.1531~1534 (2004)
- Vermeer SE, "Silent brain infarcts and the risk of dementia and cognitive decline", N Engl J Med, 348, pp.1215~1222 (2003)
- Stout JC, "Association of dementia severity with cortical gray matter and abnormal white matter volumes in dementia of the Alzheimer type", Arch Neurol, 53, pp.742~749 (1996)
- Diaz JF, "Improved recognition of leukoaraiosis and cognitive impairment in Alzheimer’s disease", Arch Neurol, 48, pp.1022~1025 (1991)
- Barber R, "White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging", J Neurol Neurosurg Psychiatry, 67, pp.66~72 (1999)
- O’Brien J, "The association between white matter lesions on magnetic resonance imaging and noncognitive symptoms", Ann N Y Acad Sci, 903, pp.482~489 (2000)
- Soennesyn H, "White matter hyperintensities and the course of depressive symptoms in elderly people with mild dementia", Dement Geriatr Cogn Dis Extra, 2, pp.97~111 (2012)
- Clark LM, "Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer’s disease", Biol Psychiatry, 44, pp.592~599 (1998)
- Harrell LE, "The relationship of high-intensity signals on magnetic resonance images to cognitive and psychiatric state in Alzheimer’s disease", Arch Neurol, 48, pp.1136~1140 (1991)
- Lind K, "Depressive symptoms and white matter changes in patients with dementia", Int J Geriatr Psychiatry, 21, pp.119~125 (2006)
- Park JH, "An overview of the Korean longitudinal study on health and aging", Psychiatry Investig, 4, pp.84~95 (2007)
- Lee JH, "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.47~53 (2002)
- The Atherosclerosis Risk in Communities, "Study: design and objectives. The ARIC investigators", Am J Epidemiol, 129, pp.687~702 (1989)
- Yoo SW, "Validity of Korean version of the Mini-International Neruopsychiatric Interview", Anxiety Mood, 2, pp.50~55 (2006)
- Americn Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" (1994), American Psychiatric Association
- McKhann G, "Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
- Cho MJ, "Validation of Geriatric Depression Scale, Korean Version (GDS) in the Assessment of DSM-III-R Major depression", J Korean Neuropsychiatr Assoc, 31, pp.48~63 (1999)
- Lee DY, "A normative study of the CERAD neuropsychological assessment battery in the Korean elderly", J Int Neuropsychol Soc, 10, pp.72~81 (2004)
- Yoo BI, "Application of variable threshold intensity to segmentation for white matter hyperintensities in fluid attenuated inversion recovery magnetic resonance images", Neuroradiology, 56, pp.265~281 (2014)
- Lichtenberg PA, "The relationship between depression and cognition in older adults: a cross-validation study", J Gerontol B Psychol Sci Soc Sci, 50, pp.25~32 (1995)
- Wilson RS, "Depressive symptoms, cognitive decline, and risk of AD in older persons", Neurology, 59, pp.364~370 (2002)
- Park JH, "A nationwide survey on the prevalence and risk factors of late life depression in South Korea", J Affect Disord, 138, pp.34~40 (2012)
- Park JH, "Prevalence of major depressive disorder and minor depressive disorder in an elderly Korean population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA)", J Affect Disord, 125, pp.234~240 (2010)
- Djernes JK, "Prevalence and predictors of depression in populations of elderly: a review", Acta Psychiatr Scand, 113, pp.372~387 (2006)
- Alexopoulos GS, "Depression in the elderly", Lancet, 365, pp.1961~1970 (2005)
- Teodorczuk A, "White matter changes and late-life depressive symptoms: longitudinal study", Br J Psychiatry, 191, pp.212~217 (2007)
- Lyketsos CG, "Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging", Am J Psychiatry, 157, pp.708~714 (2000)
- Olin JT, "Provisional diagnostic criteria for depression of Alzheimer disease: rationale and background", Am J Geriatr Psychiatry, 10, pp.129~141 (2002)
- Olin JT, "Provisional diagnostic criteria for depression of Alzheimer disease", Am J Geriatr Psychiatry, 10, pp.125~128 (2002)
- Gonzalez-Salvador T, "Quality of life in dementia patients in long-term care", Int J Geriatr Psychiatry, 15, pp.181~189 (2000)
- Bassuk SS, "Depressive symptomatology and in cident cognitive decline in an elderly community sample", Arch Gen Psychiatry, 55, pp.1073~1081 (1998)
- Lyketsos CG, "Major and minor depression in Alzheimer’s disease: prevalence and impact", J Neuropsychiatry Clin Neurosci, 9, pp.556~561 (1997)
- Gonzalez-Salvador MT, "The stress and psychological morbidity of the Alzheimer patient caregiver", Int J Geriatr Psychiatry, 14, pp.701~710 (1999)
- Janzing JG, "The relationship between depression and mortality in elderly subjects with less severe dementia", Psychol Med, 29, pp.979~983 (1999)
- O’Brien JT, "White matter lesions in depression and Alzheimer’s disease", Br J Psychiatry, 169, pp.671~ (1996)
- Forstl H, "Clinical and neuropathological correlates of depression in Alzheimer’s disease", Psychol Med, 22, pp.877~884 (1992)
- Zweig RM, "The neuropathology of aminergic nuclei in Alzheimer’s disease", Ann Neurol, 24, pp.233~242 (1988)
- Leonard BE, "Inflammation, depression and dementia: are they connected?", Neurochem Res, 32, pp.1749~1756 (2007)
- Brickman AM, "Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated", Neurosci Lett, 592, pp.54~58 (2015)
- Hickie I, "Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression--a longitudinal evaluation", Biol Psychiatry, 42, pp.367~374 (1997)
- Greenwald BS, "Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression", Stroke, 29, pp.613~617 (1998)
- Naarding P, "Post-stroke dementia and depression: frontosubcortical dysfunction as missing link?", Int J Geriatr Psychiatry, 22, pp.1~8 (2007)
- Mantyla R, "Variable agreement between visual rating scales for white matter hyperintensities on MRI. Comparison of 13 rating scales in a poststroke cohort", Stroke, 28, pp.1614~1623 (1997)
- van Straaten EC, "Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study", Stroke, 37, pp.836~840 (2006)
- Fazekas F, "MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging", AJR Am J Roentgenol, 149, pp.351~356 (1987)
- Melhem ER, "Defining thresholds for changes in size of simulated T2-hyperintense brain lesions on the basis of qualitative comparisons", AJR Am J Roentgenol, 180, pp.65~69 (2003)
- Burke WJ, "Symptoms of “depression” in dementia of the Alzheimer type", Alzheimer Dis Assoc Disord, 2, pp.356~362 (1988)
- Burke WJ, "Disagreement in the reporting of depressive symptoms between patients with dementia of the Alzheimer type and their collateral sources", Am J Geriatr Psychiatry, 6, pp.308~319 (1998)
- Teri L, "Assessment of depression in patients with Alzheimer’s disease: concordance among informants", Psychol Aging, 6, pp.280~285 (1991)
- Janzing JG, "Depression in subjects with and without dementia: a comparison using GMS-AGECAT", Int J Geriatr Psychiatry, 17, pp.1~5 (2002)
- Zubenko GS, "A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer’s disease", Am J Psychiatry, 160, pp.857~866 (2003)
