Increased Bone Mineral Density after Abstinence in Male Patients with Alcohol Dependence
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Objective: This study aimed to compare the bone mineral density of male patients with alcohol dependence with that in healthy controls and to assess changes in bone density after abstinence. Methods: Forty-four inpatients with confirmed the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnosis of alcohol abuse and 42 controls were recruited. Bone density was determined with dual-energy X-ray absorptiometry in the lumbar spine as well as in the femoral neck, trochanter, and Ward’s triangle regions of the proximal right femur. Results: There were no significant differences in age and body mass index between patients with alcohol dependence and healthy controls. In the alcohol dependence group, osteopenia and osteoporosis were found in 54.5% and 34.1% of the patients, respectively, whereas in the control group, the corresponding values were 45.2% and 11.9% (p=0.001). Although the actual bone density in the femur and the corresponding T-scores were significantly lower in the alcohol dependence group, no significant differences were found in the lumbar spine. In both groups, body mass index showed a significant correlation with bone mineral density in all areas. After 3 to 4 years of abstinence, bone density significantly increased in the lumbar and femur. Conclusion: We conclude that bone mineral density in patients with alcohol dependence was significantly lower than that in healthy controls, and the rates of osteopenia and osteoporosis are higher. Importantly, abstinence from alcohol increases bone density.
Abstract
Objective: This study aimed to compare the bone mineral density of male patients with alcohol dependence with that in healthy controls and to assess changes in bone density after abstinence. Methods: Forty-four inpatients with confirmed the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnosis of alcohol abuse and 42 controls were recruited. Bone density was determined with dual-energy X-ray absorptiometry in the lumbar spine as well as in the femoral neck, trochanter, and Ward’s triangle regions of the proximal right femur. Results: There were no significant differences in age and body mass index between patients with alcohol dependence and healthy controls. In the alcohol dependence group, osteopenia and osteoporosis were found in 54.5% and 34.1% of the patients, respectively, whereas in the control group, the corresponding values were 45.2% and 11.9% (p=0.001). Although the actual bone density in the femur and the corresponding T-scores were significantly lower in the alcohol dependence group, no significant differences were found in the lumbar spine. In both groups, body mass index showed a significant correlation with bone mineral density in all areas. After 3 to 4 years of abstinence, bone density significantly increased in the lumbar and femur. Conclusion: We conclude that bone mineral density in patients with alcohol dependence was significantly lower than that in healthy controls, and the rates of osteopenia and osteoporosis are higher. Importantly, abstinence from alcohol increases bone density.
참고문헌 (49)
- World Health Organization, "Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group", World Health Organ Tech Rep Ser, 843, pp.1~129 (1994)
- Hagino H, "Changing incidence of hip, distal radius, and proximal humerus fractures in Tottori Prefecture, Japan", Bone, 24, pp.265~270 (1999)[DOI]
- Lippuner K, "Epidemiology and direct medical costs of osteoporotic fractures in men and women in Switzerland", Osteoporos Int, 16(Suppl 2), pp.S8~S17 (2005)[DOI]
- Kanis JA, "Alcohol intake as a risk factor for fracture", Osteoporos Int, 16, pp.737~742 (2005)[DOI]
- Jung DU, "Prevalence of bone mineral density loss in Korean patients with schizophrenia: a cross-sectional study", J Clin Psychiatry, 67, pp.1391~1396 (2006)[DOI]
- Chien-Yu Chen, "Effects of Antipsychotics on Bone Mineral Density in Patients with Schizophrenia: Gender Differences", Clinical Psychopharmacology and Neuroscience, 14(3), pp.238~249 (2016), 대한정신약물학회
- Sidlauskas KM, "Osteoporosis in men: epidemiology and treatment with denosumab", Clin Interv Aging, 9, pp.593~601 (2014)
- Felson DT, "Alcohol intake and bone mineral density in elderly men and women. The Framingham Study", Am J Epidemiol, 142, pp.485~492 (1995)[DOI]
- Kouda K, "Alcohol intake and bone status in elderly Japanese men: baseline data from the Fujiwara-kyo osteoporosis risk in men (FORMEN) study", Bone, 49, pp.275~280 (2011)[DOI]
- Bikle DD, "Bone disease in alcohol abuse", Ann Intern Med, 103, pp.42~48 (1985)[DOI]
- Spencer H, "Chronic alcoholism. Frequently overlooked cause of osteoporosis in men", Am J Med, 80, pp.393~397 (1986)[DOI]
- Berg KM, "Association between alcohol consumption and both osteoporotic fracture and bone density", Am J Med, 121, pp.406~418 (2008)[DOI]
- Gonzalez-Calvin JL, "Mineral metabolism, osteoblastic function and bone mass in chronic alcoholism", Alcohol Alcohol, 28, pp.571~579 (1993)
- Peris P, "Bone mass improves in alcoholics after 2 years of abstinence", J Bone Miner Res, 9, pp.1607~1612 (1994)
- Peris P, "Vertebral fractures and osteopenia in chronic alcoholic patients", Calcif Tissue Int, 57, pp.111~114 (1995)[DOI]
- Nyquist F, "Osteopenia in alcoholics after tibia shaft fractures", Alcohol Alcohol, 32, pp.599~604 (1997)[DOI]
- Pitts TO, "Disorders of divalent ions and vitamin D metabolism in chronic alcoholism", Recent Dev Alcohol, 4, pp.357~377 (1986)
- Chakkalakal DA, "Alcohol-induced bone loss and deficient bone repair", Alcohol Clin Exp Res, 29, pp.2077~2090 (2005)[DOI]
- Callaci JJ, "Binge alcohol treatment increases vertebral bone loss following ovariectomy: compensation by intermittent parathyroid hormone", Alcohol Clin Exp Res, 30, pp.665~672 (2006)[DOI]
- Giuliani N, "Ethanol and acetaldehyde inhibit the formation of early osteoblast progenitors in murine and human bone marrow cultures", Alcohol Clin Exp Res, 23, pp.381~385 (1999)[DOI]
- Turner RT, "Skeletal response to alcohol", Alcohol Clin Exp Res, 24, pp.1693~1701 (2000)[DOI]
- Clark MK, "Bone mineral density and fractures among alcohol-dependent women in treatment and in recovery", Osteoporos Int, 14, pp.396~403 (2003)[DOI]
- Chan AW, "Racial differences in alcohol sensitivity", Alcohol Alcohol, 21, pp.93~104 (1986)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorder: DSM-IV", American Psychiatric Association, ~ (1994)
- "Dietary guidelines for Americans 2015-2020" (2015)[URL]
- Kanis JA, "The diagnosis of osteoporosis", J Bone Miner Res, 9, pp.1137~1141 (1994)
- Agrawal NK, "Prevalence of osteoporosis in otherwise healthy Indian males aged 50 years and above", Arch Osteoporos, 8, pp.116~ (2013)[DOI]
- Rhee EJ, "Age, body mass index, current smoking history, and serum insulin-like growth factor-I levels associated with bone mineral density in middle-aged Korean men", J Bone Miner Metab, 22, pp.392~398 (2004)
- 김미진, "간경변이 없는 알코올성 간질환 남자 환자에서 알코올이 골밀도에 미치는 영향", 대한내과학회지, 63(4), pp.3~378 (2002), 대한내과학회
- Khosla S, "Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen", J Clin Endocrinol Metab, 83, pp.2266~2274 (1998)
- Stepan JJ, "Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling", J Clin Endocrinol Metab, 69, pp.523~527 (1989)[DOI]
- Jarque-Lopez A, "Prevalence and mortality of heavy drinkers in a general medical hospital unit", Alcohol Alcohol, 36, pp.335~338 (2001)[DOI]
- Kimble RB, "Alcohol, cytokines, and estrogen in the control of bone remodeling", Alcohol Clin Exp Res, 21, pp.385~391 (1997)[DOI]
- Boonen S, "The diagnosis and treatment of male osteoporosis: Defining, assessing, and preventing skeletal fragility in men", Eur J Intern Med, 18, pp.6~17 (2007)[DOI]
- Korpi-Steiner N, "Osteoporosis in men", Clin Biochem, 47, pp.950~959 (2014)[DOI]
- Moayyeri A, "Preferred skeletal site for osteoporosis screening in high-risk populations", Public Health, 120, pp.863~871 (2006)[DOI]
- Kanis JA, "Diagnosis of osteoporosis and assessment of fracture risk", Lancet, 359, pp.1929~1936 (2002)[DOI]
- Nishiguchi S, "Effect of ethanol on bone mineral density of rats evaluated by dual-photon X-ray absorptiometry", J Bone Miner Metab, 18, pp.317~320 (2000)[DOI]
- Lucas R, "Early initiation of smoking and alcohol drinking as a predictor of lower forearm bone mineral density in late adolescence: a cohort study in girls", PLoS One, 7, pp.e46940~ (2012)[DOI]
- Cauley JA, "Factors associated with the lumbar spine and proximal femur bone mineral density in older men", Osteoporos Int, 16, pp.1525~1537 (2005)[DOI]
- Bendavid EJ, "Factors associated with bone mineral density in middle-aged men", J Bone Miner Res, 11, pp.1185~1190 (1996)
- Nielson CM, "BMI and fracture risk in older men: the osteoporotic fractures in men study (MrOS)", J Bone Miner Res, 26, pp.496~502 (2011)[DOI]
- Burger H, "Risk factors for increased bone loss in an elderly population: the Rotterdam Study", Am J Epidemiol, 147, pp.871~879 (1998)[DOI]
- Eleftheriou KI, "Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity", Bone, 52, pp.17~26 (2013)[DOI]
- Kelly KN, "Pattern and cause of fractures in patients who abuse alcohol: what should we do about it?", Postgrad Med J, 89, pp.578~583 (2013)[DOI]
- Alvisa-Negrin J, "Osteopenia in alcoholics: effect of alcohol abstinence", Alcohol Alcohol, 44, pp.468~475 (2009)[DOI]
- Malik P, "Markers of bone resorption and formation during abstinence in male alcoholic patients", Alcohol Clin Exp Res, 36, pp.2059~2064 (2012)[DOI]
- Malik P, "Osteoprotegerin levels decrease in abstinent alcohol-dependent patients", Alcohol Clin Exp Res, 40, pp.1235~1240 (2016)[DOI]
- Trouvin AP, "Receptor activator of nuclear factor-<TEX>${\kappa}B$<", TEX> ligand and osteoprotegerin: maintaining the balance to prevent bone loss, 2010, pp.5, 345~354