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Plasma Apelin, Visfatin and Resistin Levels in Patients with First Episode Psychosis and Chronic Schizophrenia

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Objective: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. Methods: A total number of 29 untreated patients with first episode psychosis, 30 chronic schizophrenia and 29 randomly selected weight- and body mass index-matched healthy volunteers were included. The Diagnostic and Statistical Manual of Mental Disorders 4th edition, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression Scale were applied to the patient groups. The enzyme-linked immunosorbent assay method was used to measure plasma apelin, visfatin and resistin levels. Results: There was no difference in age, marital status, occupation, and BMI between the groups. Plasma apelin levels were significantly higher in first episode psychosis group than chronic schizophrenia and control group. There was no statistically significant difference in plasma visfatin levels between the groups: first episode psychosis group, chronic schizophrenia and control group. Plasma resistin levels were higher in both first episode psychosis group and chronic schizophrenia group than the control group. There was no statistically significant correlation between plasma apelin and resistin levels and total PANSS scores in the group of patients. Conclusion: To our knowledge, this study is the first which investigates the plasma apelin, visfatin and resistin levels in patients with first episode psychosis and chronic schizophrenia. Based on the results of this study, apelin and resistin may be related with some central nervous system pathologies, including the severity of a psychiatric disorder.

Abstract

Objective: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. Methods: A total number of 29 untreated patients with first episode psychosis, 30 chronic schizophrenia and 29 randomly selected weight- and body mass index-matched healthy volunteers were included. The Diagnostic and Statistical Manual of Mental Disorders 4th edition, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression Scale were applied to the patient groups. The enzyme-linked immunosorbent assay method was used to measure plasma apelin, visfatin and resistin levels. Results: There was no difference in age, marital status, occupation, and BMI between the groups. Plasma apelin levels were significantly higher in first episode psychosis group than chronic schizophrenia and control group. There was no statistically significant difference in plasma visfatin levels between the groups: first episode psychosis group, chronic schizophrenia and control group. Plasma resistin levels were higher in both first episode psychosis group and chronic schizophrenia group than the control group. There was no statistically significant correlation between plasma apelin and resistin levels and total PANSS scores in the group of patients. Conclusion: To our knowledge, this study is the first which investigates the plasma apelin, visfatin and resistin levels in patients with first episode psychosis and chronic schizophrenia. Based on the results of this study, apelin and resistin may be related with some central nervous system pathologies, including the severity of a psychiatric disorder.

참고문헌 (48)

  1. Abdullah Bolu, "Serum Levels of High Sensitivity C-reactive Protein in Drug-naïve First-episode Psychosis and Acute Exacerbation of Schizophrenia", Clinical Psychopharmacology and Neuroscience, 17(2), pp.244~249 (2019), 대한정신약물학회[DOI]
  2. Beumer W, "Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome", Psychoneuroendocrinology, 37, pp.1901~1911 (2012)
  3. Strous RD, "Schizophrenia, autoimmunity and immune system dysregulation : a comprehensive model updated and revisited", J Autoimmun, 27, pp.71~80 (2006)
  4. Nillni EA, "Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways", J Biol Chem, 275, pp.36124~36133 (2000)
  5. Rybakowski F, "Inverse relationship between leptin increase and improvement in depressive symptoms in anorexia nervosa", Neuro Endocrinol Lett, 35, pp.64~67 (2014)
  6. Beumer W, "The immune theory of psychiatric diseases : a key role for activated microglia and circulating monocytes", J Leukoc Biol, 92, pp.959~975 (2012)
  7. Shelton RC, "Inflammation in depression : is adiposity a cause", Dialogues Clin Neurosci, 13, pp.41~53 (2011)
  8. Antoniades C, "Adiponectin : from obesity to cardiovascular disease", Obes Rev, 10, pp.269~279 (2009)
  9. Ronti T, "The endocrine function of adipose tissue: an update", Clin Endocrinol (Oxf), 64, pp.355~365 (2006)
  10. Tatemoto K, "Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor", Biochem Biophys Res Commun, 251, pp.471~476 (1998)
  11. Reaux A, "Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain", J Neurochem, 77, pp.1085~1096 (2001)
  12. Filippatos TD, "Increased plasma visfatin levels in subjects with the metabolic syndrome", Eur J Clin Invest, 38, pp.71~72 (2008)
  13. Ognjanovic S, "Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes", Am J Obstet Gynecol, 187, pp.1051~1058 (2002)
  14. Moschen AR, "Visfatin, an adipocytokine with proinflammatory and immunomodulating properties", J Immunol, 178, pp.1748~1758 (2007)
  15. Seden Demirci, "The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer’s Disease", Clinical Psychopharmacology and Neuroscience, 15(1), pp.59~63 (2017), 대한정신약물학회[DOI]
  16. Brunetti L, "Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings", Eur J Pharmacol, 372, pp.237~240 (1999)
  17. Kay SR, "The positive and negative syndrome scale(PANSS)for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
  18. Guy W, "ECDEU assessment manual for psychopharmacology", US Department of Health and Human Services Publication, 218~222 (1976)
  19. O’Carroll AM, "The apelin receptor APJ : journey from an orphan to a multifaceted regulator of homeostasis", J Endocrinol, 219, pp.R13~R35 (2013)
  20. Kleinz MJ, "Emerging roles of apelin in biology and medicine", Pharmacol Ther, 107, pp.198~211 (2005)
  21. Cheng B, "Neuroprotection of apelin and its signaling pathway", Peptides, 37, pp.171~173 (2012)
  22. Lv SY, "Central apelin-13 inhibits food intake via the CRF receptor in mice", Peptides, 33, pp.132~138 (2012)
  23. Sunter D, "Intracerebroventricular injection of apelin-13 reduces food intake in the rat", Neurosci Lett, 353, pp.1~4 (2003)
  24. Christensen L, "The effect of food intake on mood", Clin Nutr, 20, pp.161~166 (2001)
  25. Licinio-Paixao J, "Hyperinsulinemia; a mediator of decreased food intake and weight loss in anorexia nervosa and major depression", Med Hypotheses, 28, pp.125~130 (1989)
  26. Kokare DM, "Involvement of alpha-MSH in the social isolation induced anxiety-and depression-like behaviors in rat", Neuropharmacology, 58, pp.1009~1018 (2010)
  27. Holsboer F, "The rationale for corticotropin-releasing hormone receptor(CRH-R)antagonists to treat depression and anxiety", J Psychiatr Res, 33, pp.181~214 (1999)
  28. Stogner KA, "Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats", Eur J Pharmacol, 387, pp.R9~R10 (2000)
  29. Lutter M, "The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress", Nat Neurosci, 11, pp.752~753 (2008)
  30. Newson MJF, "The effects of apelin on hypothalamic−pituitary−adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor-and vasopressin-dependent mechanisms", J Endocrinol, 202, pp.123~129 (2009)
  31. Zeng XJ, "Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons", Exp Cell Res, 316, pp.1773~1783 (2010)
  32. O’Donnell LA, "Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury", J Neurochem, 102, pp.1905~1917 (2007)
  33. Kitani T, "Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor", FEBS Lett, 544, pp.74~78 (2003)
  34. Samal B, "Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor", Mol Cell Biol, 14, pp.1431~1437 (1994)
  35. Lu LF, "Elevated visfatin", pre-B-cell colony-enhancing factor plasma concentration in ischemic stroke, 2009, pp.18, 354~359
  36. Zhang W, "Neuronal protective role of PBEF in a mouse model of cerebral ischemia", J Cereb Blood Flow Metab, 30, pp.1962~1971 (2010)
  37. Ghaffari MA, "Increased serum levels of tumor necrosis factor-alpha, resistin, and visfatin in the children with autism spectrum disorders : a case-control study", Neurol Res Int, 2016, pp.9060751~ (2016)
  38. Dostálová I, "Serum visfatin levels in patients with anorexia nervosa and bulimia nervosa", Physiol Res, 58, pp.903~907 (2009)
  39. Ziora K, "Assessment of serum visfatin levels in girls with anorexia nervosa", Clin Endocrinol(Oxf), 76, pp.514~519 (2012)
  40. Patel L, "Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators", Biochem Biophys Res Commun, 300, pp.472~476 (2003)
  41. Zeugmann S, "Inflammatory biomarkers in 70 depressed inpatients with and without the metabolic syndrome", J Clin Psychiatry, 71, pp.1007~1016 (2010)
  42. Weber-Hamann B, "Resistin and adiponectin in major depression : the association with free cortisol and effects of antidepressant treatment", J Psychiatr Res, 41, pp.344~350 (2007)
  43. Brunetti L, "Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus", Eur J Pharmacol, 493, pp.41~44 (2004)
  44. Yumru M, "Serum resistin levels and metabolic changes in bipolar disorder", J Mood Disord, 2, pp.47~50 (2012)
  45. Dostalova I, "Adipose tissue resistin levels in patients with anorexia nervosa", Nutrition, 22, pp.977~983 (2006)
  46. Rodrigues DH, "Changes in adipokine levels in autism spectrum disorders", Neuropsychobiology, 69, pp.6~10 (2014)
  47. Ari M, "Serum adiponectin and resistin levels in patients with obsessive compulsive disorder", J Affect Disord, 136, pp.979~982 (2012)
  48. Balõtšev R, "Antipsychotic treatment is associated with inflammatory and metabolic biomarkers alterations among first-episode psychosis patients : a 7-month follow-up study", Early Interv Psychiatry, 13, pp.101~109 (2019)

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