Serum Levels of High Sensitivity C-reactive Protein in Drug-naïve First-episode Psychosis and Acute Exacerbation of Schizophrenia
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Objective: Findings about inflammatory processes in schizophrenia are increasing day by day. Inflammatory processes in schizophrenia are associated with both its etiology and clinical symptoms. Serum high-sensitivity C-reactive protein (hsCRP) is also one of these inflammatory processes. Particularly, it is thought to be closely related to clinical findings of patients with schizophrenia. Methods: In this study, the relationship between clinical findings of hsCRP levels of patients with drug-naïve first-episode psychosis (FEP) and patients with schizophrenia in acute exacerbation phase is investigated. Clinical findings, psychometric properties (the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, Brief Psychiatric Rating Scale), and hsCRP levels of patients were compared. Results: Forty-eight patients with FEP, 74 patients with schizophrenia in acute exacerbation phase and 54 healthy controlled volunteers are included in the study. The most substantial finding in the study is that there is a positive correlation between hsCRP levels and severity of positive symptoms of both patient groups, with FEP and with schizophrenia. The second most substantial finding is there is no significant difference between patients with FEP and schizophrenia, in terms of hsCRP. Conclusion: The relationship between hsCRP and positive symptom severity in two groups of patients supports the inflammatory hypothesis in the etiopathogenesis of schizophrenia. This finding is supportive of close relation between inflammatory processes and clinical findings of patient with schizophrenia.
Abstract
Objective: Findings about inflammatory processes in schizophrenia are increasing day by day. Inflammatory processes in schizophrenia are associated with both its etiology and clinical symptoms. Serum high-sensitivity C-reactive protein (hsCRP) is also one of these inflammatory processes. Particularly, it is thought to be closely related to clinical findings of patients with schizophrenia. Methods: In this study, the relationship between clinical findings of hsCRP levels of patients with drug-naïve first-episode psychosis (FEP) and patients with schizophrenia in acute exacerbation phase is investigated. Clinical findings, psychometric properties (the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, Brief Psychiatric Rating Scale), and hsCRP levels of patients were compared. Results: Forty-eight patients with FEP, 74 patients with schizophrenia in acute exacerbation phase and 54 healthy controlled volunteers are included in the study. The most substantial finding in the study is that there is a positive correlation between hsCRP levels and severity of positive symptoms of both patient groups, with FEP and with schizophrenia. The second most substantial finding is there is no significant difference between patients with FEP and schizophrenia, in terms of hsCRP. Conclusion: The relationship between hsCRP and positive symptom severity in two groups of patients supports the inflammatory hypothesis in the etiopathogenesis of schizophrenia. This finding is supportive of close relation between inflammatory processes and clinical findings of patient with schizophrenia.
참고문헌 (31)
- Porteous D, "Genetic causality in schizophrenia and bipolar disorder : out with the old and in with the new", Curr Opin Genet Dev, 18, pp.229~234 (2008)
- Singh B, "Role of C-reactive protein in schizophrenia : an overview", Psychiatry Res, 216, pp.277~285 (2014)
- Khandaker GM, "Inflammation and immunity in schizophrenia : implications for pathophysiology and treatment", Lancet Psychiatry, 2, pp.258~270 (2015)
- Wium-Andersen MK, "Elevated C-reactive protein associated with late-and very-late-onset schizophrenia in the general population : a prospective study", Schizophr Bull, 40, pp.1117~1127 (2014)
- Pepys MB, "C-reactive protein : a critical update", J Clin Invest, 111, pp.1805~1812 (2003)
- Ruth MR, "Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein cholesterol in obese subjects", Metabolism, 62, pp.1779~1787 (2013)
- Capuron L, "Relationship between adiposity, emotional status and eating behaviour in obese women : role of inflammation", Psychol Med, 41, pp.1517~1528 (2011)
- Miller BJ, "C-reactive protein levels in schizophrenia : a review and meta-analysis", Clin Schizophr Relat Psychoses, 7, pp.223~230 (2014)
- Fernandes BS, "C-reactive protein is increased in schizophrenia but is not altered by antipsychotics : meta-analysis and implications", Mol Psychiatry, 21, pp.554~564 (2016)
- Akanji AO, "Association of blood levels of C-reactive protein with clinical phenotypes in Arab schizophrenic patients", Psychiatry Res, 169, pp.56~61 (2009)
- Fawzi MH, "C-reactive protein serum level in drug-free male Egyptian patients with schizophrenia", Psychiatry Res, 190, pp.91~97 (2011)
- Dickerson F, "C-reactive protein is elevated in schizophrenia", Schizophr Res, 143, pp.198~202 (2013)
- Joseph J, "Associations of high sensitivity C-reactive protein levels in schizophrenia and comparison groups", Schizophr Res, 168, pp.456~460 (2015)
- Inoshita M, "A significant causal association between C-reactive protein levels and schizophrenia", Sci Rep, 6, pp.26105~ (2016)
- Lukoff D, "Brief Psychiatric Rating Scale (BPRS) Version 4.0, Expanded Version", UCLA Department of Psychiatry and Biobehaviriol Sciences, West Los Angeles Medical Center, ~ (1993)
- Soykan C, "Institutional differences, and case typicality as related to diagnosis system severity, prognosis and treatment", Master's, pp.1989
- Andreasen NC, "Schizophrenia: Positive and negative symptoms and syndromes", pp.73~78 (1990), Karger
- Erkoc S, "Negatif semptomları değerlendirme ölçeğinin güvenilirliği ve geçerliliği", Düşünen Adam, 4, pp.16~19 (1991)
- Erkoc S, "Pozitif semptomları değerlendirme ölçeğinin güvenilirliği ve geçerliliği", Düşünen Adam, 4, pp.20~24 (1991)
- Gibney SM, "Evidence for a dysregulated immune system in the etiology of psychiatric disorders", J Neuroimmune Pharmacol, 8, pp.900~920 (2013)
- Annya M. Smyth, "The Neuroimmunology of Schizophrenia", Clinical Psychopharmacology and Neuroscience, 11(3), pp.107~117 (2013), 대한정신약물학회
- Ganesan Venkatasubramanian, "Neuroimmunological Aberrations and Cerebral Asymmetry Abnormalities in Schizophrenia: Select Perspectives on Pathogenesis", Clinical Psychopharmacology and Neuroscience, 12(1), pp.8~18 (2014), 대한정신약물학회
- Strous RD, "Schizophrenia, autoimmunity and immune system dysregulation : a comprehensive model updated and revisited", J Autoimmune, 27, pp.71~80 (2006)
- Potvin S, "Inflammatory cytokine alterations in schizophrenia : a systematic quantitative review", Biol Psychiatry, 63, pp.801~808 (2008)
- Zhang Q, "Increased ratio of high sensitivity C-reactive protein to interleukin-10 as a potential peripheral biomarker of schizophrenia and aggression", Int J Psychophysiol, 114, pp.9~15 (2017)
- Fan X, "Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia", Psychiatry Res, 149, pp.267~271 (2007)
- Garcia-Rizo C, "Inflammatory markers in antipsychotic- naive patients with nonaffective psychosis and deficit vs. nondeflcit features", Psychiatry Res, 198, pp.212~215 (2012)
- Dickerson F, "Additive effects of elevated C-reactive protein and exposure to Herpes simplex virus type 1 on cognitive impairment in individuals with schizophrenia", Schizophr Res, 134, pp.83~88 (2012)
- Dimitrov DH, "Elevated serum levels of high-sensitivity C-reactive proteins are associated with severe delusional symptoms in a subgroup of patients with schizophrenia", J Clin Psychiatry, 77, pp.131~132 (2016)
- Barzilay R, "Elevated C-reactive protein levels in schizophrenia inpatients is associated with aggressive behavior", Eur Psychiatry, 31, pp.8~12 (2016)
- De Berardis D, "C-reactive protein level and its relationship with suicide risk and alexithymia among newly diagnosed, drug-naive patients with non-affective psychosis", Eur J Inflamm, 11, pp.215~221 (2013)