Anorectal Manometric Dysfunctions in Newly Diagnosed, Early-Stage Parkinson’s Disease
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Background and Purpose Anorectal dysmotility is common in advanced Parkinson’s disease (PD), but there have been few evaluations in newly diagnosed PD patients. Methods We conducted anorectal manometric evaluations in 19 newly diagnosed, drug-naïve,early-stage PD patients. All of the PD patients were questioned regarding the presence of anorectal symptoms. Results Anorectal manometry was abnormal in 12 of the 19 patients. These abnormalities were more common in patients with more severe anorectal symptoms, as measured using a self-reported scale. However, more than 40% of patients with no or minimal symptoms also exhibited manometric abnormalities. Conclusions These results suggest that anorectal dysmotility manifests in many early-stage PD patients, which this represent evidence for the involvement of neuronal structures in such nonmotor manifestations in PD.
Abstract
Background and Purpose Anorectal dysmotility is common in advanced Parkinson’s disease (PD), but there have been few evaluations in newly diagnosed PD patients. Methods We conducted anorectal manometric evaluations in 19 newly diagnosed, drug-naïve,early-stage PD patients. All of the PD patients were questioned regarding the presence of anorectal symptoms. Results Anorectal manometry was abnormal in 12 of the 19 patients. These abnormalities were more common in patients with more severe anorectal symptoms, as measured using a self-reported scale. However, more than 40% of patients with no or minimal symptoms also exhibited manometric abnormalities. Conclusions These results suggest that anorectal dysmotility manifests in many early-stage PD patients, which this represent evidence for the involvement of neuronal structures in such nonmotor manifestations in PD.
참고문헌 (17)
- Abbott RD, "Frequency of bowel movements and the future risk of Parkinson’s disease", Neurology, 57, pp.456~462 (2001)
- Braak H, "Gastric alpha-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology", Neurosci Lett, 396, pp.67~72 (2006)
- Hawkes CH, "Parkinson’s disease: a dual-hit hypothesis", Neuropathol Appl Neurobiol, 33, pp.599~614 (2007)
- Ashraf W, "Anorectal manometry in the assessment of anorectal function in Parkinson’s disease: a comparison with chronic idiopathic constipation", Mov Disord, 9, pp.655~663 (1994)
- Edwards LL, "Characterization of swallowing and defecation in Parkinson’s disease", Am J Gastroenterol, 89, pp.15~25 (1994)
- Stocchi F, "Anorectal function in multiple system atrophy and Parkinson’s disease", Mov Disord, 15, pp.71~76 (2000)
- Kim JS, "Anorectal dysfunctions in Parkinson’s disease", J Neurol Sci, 310, pp.144~151 (2011)
- Bassotti G, "Manometric investigation of anorectal function in early and late stage Parkinson’s disease", J Neurol Neurosurg Psychiatry, 68, pp.768~770 (2000)
- Gibb WR, "The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease", J Neurol Neurosurg Psychiatry, 51, pp.745~752 (1988)
- Rao SS, "Minimum standards of anorectal manometry", Neurogastroenterol Motil, 14, pp.553~559 (2002)
- Mathers SE, "Constipation and paradoxical puborectalis contraction in anismus and Parkinson’s disease: a dystonic phenomenon?", J Neurol Neurosurg Psychiatry, 51, pp.1503~1507 (1988)
- Mathers SE, "Anal sphincter dysfunction in Parkinson’s disease", Arch Neurol, 46, pp.1061~1064 (1989)
- Jost WH, "Gastrointestinal dysfunction in Parkinson’s Disease", J Neurol Sci, 289, pp.69~73 (2010)
- Bharucha AE, "Constipation", Best Pract Res Clin Gastroenterol, 21, pp.709~731 (2007)
- Meagher AP, "The cough response of the anal sphincter", Int J Colorectal Dis, 8, pp.217~219 (1993)
- Amarenco G, "Cough anal reflex: strict relationship between intravesical pressure and pelvic floor muscle electromyographic activity during cough. Urodynamic and electrophysiological study", J Urol, 173, pp.149~152 (2005)
- Deffieux X, "External anal sphincter contraction during cough: not a simple spinal reflex", Neurourol Urodyn, 25, pp.782~787 (2006)