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Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

김동수|최한규|류재숙|오상태|박갑만|이석준
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2005.09|Parasites, Hosts and Diseases|제43권 제3호|pp. 123-126

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참고문헌

주제분류예방의학/직업환경의학

초록

Abstract

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized fromartemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falci-parum. Three of the four tested compounds were found to be effective. Especially, 10β-benzenesulfonyl-dihy-droartemisinin showed stronger antimalarial activity than artemisinin.

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