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First Report of Neutrophil Involvement of Exflagellated Plasmodium vivax Microgametes

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주제분류병리학

초록

Dear editor Malarial infections pass through multiple stages, beginning in the hepatic parenchymal cells where invading sporozoites ma- ture into schizonts. On maturation, these schizonts rupture and release merozoites into the bloodstream, which, in turn, target erythrocytes, leading to the clinical manifestations of the disease [1]. Exflagellation is characterized by thin, flagella-shaped mi- crogametes emerging from male malaria gametocytes; occurs in the midgut of the Anopheles mosquito; and has rarely been observed in peripheral blood specimens.

Abstract

Dear editor Malarial infections pass through multiple stages, beginning in the hepatic parenchymal cells where invading sporozoites ma- ture into schizonts. On maturation, these schizonts rupture and release merozoites into the bloodstream, which, in turn, target erythrocytes, leading to the clinical manifestations of the disease [1]. Exflagellation is characterized by thin, flagella-shaped mi- crogametes emerging from male malaria gametocytes; occurs in the midgut of the Anopheles mosquito; and has rarely been observed in peripheral blood specimens.

참고문헌 (9)

  1. McPherson RA, "Henry’s clinical diagnosis and management by laboratory methods. 22nd ed", pp.1197~1204 (2011), Saunders
  2. MacCallum WG, "On the flagellated form of the malarial parasite", The Lancet, 11, pp.1240~1241 (1897)
  3. Harish Chandra, "Gametocytes of Plasmodium falciparum in the megakaryocytes", Blood Research, 46(2), pp.68~68 (2011), 대한혈액학회
  4. Carter R, "Control of gamete formation (exflagellation) in malaria parasites", Science, 195, pp.407~409 (1977)
  5. Ogwan’g RA, "Factors affecting exflagellation of in vitro-cultivated Plasmodium falciparum gametocytes", Am J Trop Med Hyg, 49, pp.25~29 (1993)
  6. McPherson RA, "Henry’s clinical diagnosis and management by laboratory methods. 22nd ed", pp.1242~ (2011), Saunders
  7. Trubowitz S, "Plasmodium falciparum: phagocytosis by polymorphonuclear leukocytes", Science, 162, pp.273~274 (1968)
  8. Ritter U, "Are neutrophils important host cells for Leishmania parasites?", Trends Parasitol, 25, pp.505~510 (2009)
  9. Squier MK, "Apoptosis in leukocytes", J Leukoc Biol, 57, pp.2~10 (1995)

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