Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice
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Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the ma- laria parasite Plasmodium berghei is similar to that of Toxoplasma gondii. Inner membrane complex is known to be in- volved in cell invasion and replication. In this study, we investigated the resistance against T. gondii (ME49) infection in- duced by previously infected P. berghei (ANKA) in mice. Levels of T. gondii-specific IgG, IgG1, IgG2a, and IgG2b antibody responses, CD4+ and CD8+ T cell populations were found higher in the mice infected with P. berghei (ANKA) and chal- lenged with T. gondii (ME49) compared to that in control mice infected with T. gondii alone (ME49). P. berghei (ANKA) + T. gondii (ME49) group showed significantly reduced the number and size of T. gondii (ME49) cysts in the brains of mice, re- sulting in lower body weight loss compared to ME49 control group. These results indicate that previous exposure to P. berghei (ANKA) induce resistance to subsequent T. gondii (ME49) infection.
Abstract
Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the ma- laria parasite Plasmodium berghei is similar to that of Toxoplasma gondii. Inner membrane complex is known to be in- volved in cell invasion and replication. In this study, we investigated the resistance against T. gondii (ME49) infection in- duced by previously infected P. berghei (ANKA) in mice. Levels of T. gondii-specific IgG, IgG1, IgG2a, and IgG2b antibody responses, CD4+ and CD8+ T cell populations were found higher in the mice infected with P. berghei (ANKA) and chal- lenged with T. gondii (ME49) compared to that in control mice infected with T. gondii alone (ME49). P. berghei (ANKA) + T. gondii (ME49) group showed significantly reduced the number and size of T. gondii (ME49) cysts in the brains of mice, re- sulting in lower body weight loss compared to ME49 control group. These results indicate that previous exposure to P. berghei (ANKA) induce resistance to subsequent T. gondii (ME49) infection.
참고문헌 (27)
- "Water-related Diseases: Malaria"[URL]
- Mueller I, "Development of vaccines for Plasmodium vivax malaria", Vaccine, 33, pp.7489~7495 (2015)
- Lee DH, "Cross-protection induced by Toxoplasma gondii virus-like particle vaccine upon intraperitoneal route challenge", Acta Trop, 164, pp.77~83 (2016)
- Lee SH, "Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection", PLoS One, 12, pp.e0175644~ (2017)
- Kono M, "Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite", Mol Biol Evol, 29, pp.2113~2132 (2012)
- Ouologuem DT, "Dynamics of the Toxoplasma gondii inner membrane complex", J Cell Sci, 127, pp.3320~3330 (2014)
- Lee DH, "Virus-like nanoparticle vaccine confers protection against Toxoplasma gondii", PLoS One, 11, pp.e0161231~ (2016)
- Parkyn Schneider M, "Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development", PLoS Pathog, 13, pp.e1006659~ (2017)
- Harding CR, "The inner membrane complex through development of Toxoplasma gondii and Plasmodium", Cell Microbiol, 16, pp.632~641 (2014)
- Butler NS, "Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections : more parallels than distinctions", Trends Parasitol, 29, pp.593~602 (2013)
- Onkoba NW, "Malaria endemicity and co-infection with tissue-dwelling parasites in Sub-Saharan Africa : a review", Infect Dis Poverty, 4, pp.35~ (2015)
- Mengs U, "The course of Plasmodium berghei infection in mice latently infected with Toxoplasma gondii", Experientia, 38, pp.570~571 (1982)
- 강해지, "Virus-Like Particles Expressing Toxoplasma gondii Rhoptry Protein 18 Induces Better Protection Than Rhoptry Protein 4 against T. gondii Infection", Parasites, Hosts and Diseases, 56(5), pp.429~435 (2018), 대한기생충학ㆍ열대의학회
- Fairlie-Clarke KJ, "Antibody isotype analysis of malaria-nematode co-infection : problems and solutions associated with cross-reactivity", BMC Immunol, 11, pp.6~ (2010)
- Cao Y, "Construction of transgenic Plasmodium berghei as a model for evaluation of blood-stage vaccine candidate of Plasmodium falciparum chimeric protein 2.9", PLoS One, 4, pp.e6894~ (2009)
- Somsak V, "Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I", Acta Trop, 122, pp.113~118 (2012)
- Susanto L, "Preparation of Toxoplasma gondii RH strain antigen, antigen analysis and antigen detection in sera : a review", Southeast Asian J Trop Med Public Health, 32, pp.195~201 (2001)
- 이수화, "Influenza M1 Virus-Like Particles Consisting of Toxoplasma gondii Rhoptry Protein 4", Parasites, Hosts and Diseases, 55(2), pp.143~148 (2017), 대한기생충학ㆍ열대의학회[DOI]
- Chu KB, "The resistance against Trichinella spiralis infection induced by primary infection with respiratory syncytial virus", Parasitology, 146, pp.634~642 (2019)
- Rifaat MA, "Experimental concomitant toxoplasma and malaria infection in rats", Folia Parasitol, 31, pp.97~104 (1984)
- Omata Y, "Different appearance of parasitized erythrocytes in blood between normal and toxoplasma-infected rats after infection of Plasmodium berghei", Zentralbl Bakteriol Orig A, 244, pp.362~373 (1979)
- White WI, "Antimalarial antibodies of the immunoglobulin G2a isotype modulate parasitemias in mice infected with Plasmodium yoelii", Infect Immun, 59, pp.3547~3554 (1991)
- Ahmed N, "Toxoplasma co-infection prevents Th2 differentiation and leads to a helminth-specific Th1 response", Front Cell Infect Microbiol, 7, pp.341~ (2017)
- Chew WK, "Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis", Antimicrob Agents Chemother, 56, pp.1762~1768 (2012)
- Charest H, "Recombinant attenuated Toxoplasma gondii expressing the Plasmodium yoelii circumsporozoite protein provides highly effective priming for CD8+ T cell-dependent protective immunity against malaria", J Immunol, 165, pp.2084~2092 (2000)
- Ademola IO, "Co-infection with Plasmodium berghei and Trypanosoma brucei increases severity of malaria and trypanosomiasis in mice", Acta Trop, 159, pp.29~35 (2016)
- Santiago HC, "Coinfection with Toxoplasma gondii inhibits antigen-specific Th2 immune responses, tissue inflammation, and parasitism in BALB", c mice infected with Leishmania major, 1999, pp.67, 4939~4944