본문 바로가기
KERD
논문KCI 등재

Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part I-Development

3

조회

0

다운로드

7

인용

0

참고문헌

키워드

주제분류병리학

초록

The process of method development for a diagnostic assay based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) involves several disparate technologies and specialties. Additionally, method development details are typically not disclosed in journal publications. Method developers may need to search widely for pertinent information on their assay(s). This review summarizes the current practices and procedures in method development. Additionally, it probes aspects of method development that are generally not discussed, such as how exactly to calibrate an assay or where to place quality controls, using examples from the literature. This review intends to provide a comprehensive resource and induce critical thinking around the experiments for and execution of developing a clinically meaningful LC-MS/MS assay.

Abstract

The process of method development for a diagnostic assay based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) involves several disparate technologies and specialties. Additionally, method development details are typically not disclosed in journal publications. Method developers may need to search widely for pertinent information on their assay(s). This review summarizes the current practices and procedures in method development. Additionally, it probes aspects of method development that are generally not discussed, such as how exactly to calibrate an assay or where to place quality controls, using examples from the literature. This review intends to provide a comprehensive resource and induce critical thinking around the experiments for and execution of developing a clinically meaningful LC-MS/MS assay.

참고문헌 (149)

  1. Benton SC, "Evaluation of the 25-hydroxy vitamin D assay on a fully automated liquid chromatography mass spectrometry system, the Thermo Scientific Cascadion SM Clinical Analyzer with the Cascadion 25-hydroxy vitamin D assay in a routine clinical laboratory", Clin Chem Lab Med, 58, pp.1010~1017 (2020)
  2. Metz TF, "Evaluation of a novel, commercially available mass spectrometry kit for newborn screening including succinylacetone without hydrazine", Clin Chim Acta, 413, pp.1259~1264 (2012)
  3. Polledri E, "Immunosuppressive drugs in whole blood : validation of a commercially available liquid chromatography", tandem mass spectrometry kit and comparison with immunochemical assays, 2017, pp.31, 1111~1120
  4. Duncan MW, "Applications of MALDI mass spectrometry in clinical chemistry", Clin Chem, 62, pp.134~143 (2016)
  5. Croxatto A, "Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology", FEMS Microbiol Rev, 36, pp.380~407 (2012)
  6. Millington DS, "Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography", mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue, 1989, pp.180, 331~339
  7. Jones PM, "Clinical Applications of Mass Spectrometry", pp.423~431 (2010), Humana Press
  8. Singh RJ, "Precisely wrong? Urinary fractionated metanephrines and peer-based laboratory proficiency testing", Clin Chem, 51, pp.472~473 (2005)
  9. Hanari N, "Variation in concentration of perfluorooctanoic acid in methanol solutions during storage", Chemosphere, 94, pp.116~120 (2014)
  10. Wise SA, "What is novel about certified reference materials?", Anal Bioanal Chem, 410, pp.2045~2049 (2018)
  11. 최기환, "Purity assessment using quantitative NMR: establishment of SI traceability in organic analysis", Journal of the Korean Magnetic Resonance Society, 24(1), pp.30~37 (2020), 한국자기공명학회[DOI]
  12. Malz F, "Validation of quantitative NMR", J Pharm Biomed Anal, 38, pp.813~823 (2005)
  13. "Everything you wanted to know about internal standards but were too afraid to ask. Part 1: What, why, and how" (2020)[URL]
  14. Shuford CM, "Absolute protein quantification by mass spectrometry : not as simple as advertised", Anal Chem, 89, pp.7406~7415 (2017)
  15. Leinenbach A, "Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal fluid", Clin Chem, 60, pp.987~994 (2014)
  16. Tai SS, "Development and evaluation of a reference measurement procedure for the determination of estradiol-17β in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry", Anal Chem, 77, pp.6359~6363 (2005)
  17. Tai SS, "Development and evaluation of a candidate reference method for the determination of total cortisol in human serum using isotope dilution liquid chromatography", mass spectrometry and liquid chromatography, Anal Chem, pp.2004, 76[DOI]
  18. Lindegardh N, "Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma : stable isotope labeled internal standard does not always compensate for matrix effects", J Chromatogr B Analyt Technol Biomed Life Sci, 862, pp.227~236 (2008)
  19. Berg T, "13C labelled internal standards-a solution to minimize ion suppression effects in liquid chromatography-tandem mass spectrometry analyses of drugs in biological samples?", J Chromatogr A, 1218, pp.9366~9374 (2011)
  20. Davison AS, "Potential problems with using deuterated internal standards for liquid chromatography-tandem mass spectrometry", Ann Clin Biochem, 50, pp.274~ (2013)
  21. "How to pipette small volumes with handheld manual pipettes" (2020)[URL]
  22. Liigand J, "pH effects on electrospray ionization efficiency", J Am Soc Mass Spectrom, 28, pp.461~469 (2017)
  23. Rauha JP, "Effect of eluent on the ionization efficiency of flavonoids by ion spray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization mass spectrometry", J Mass Spectrom, 36, pp.1269~1280 (2001)
  24. Deventer K, "Development and validation of an LC-MS", MS method for the quantification of ephedrines in urine, 2009, pp.877, 369~374
  25. Eyles D, "A sensitive LC", MS, Clin Chim Acta, pp.2009, 403[DOI]
  26. Ferreiro-Vera C, "Standard operation protocol for analysis of lipid hydroperoxides in human serum using a fully automated method based on solid-phase extraction and liquid chromatography-mass spectrometry in selected reaction monitoring", J Chromatogr A, 1218, pp.6720~6726 (2011)
  27. Kuhn J, "Sample cleanup-free determination of mycophenolic acid and its glucuronide in serum and plasma using the novel technology of ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry", Talanta, 80, pp.1894~1898 (2010)
  28. Bittersohl H, "A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples", J Chromatogr A, 1547, pp.45~52 (2018)
  29. Rappold BA, "Mass spectrometry selectivity, specifically", Clin Chem, 62, pp.154~156 (2016)
  30. Bunch DR, "Investigation of transition ion ratio variation for liquid chromatography-tandem mass spectrometry : a case study approach", Clin Chim Acta, 486, pp.205~208 (2018)
  31. Kushnir MM, "Assessing analytical specificity in quantitative analysis using tandem mass spectrometry", Clin Biochem, 38, pp.319~327 (2005)
  32. Rappold BA, "Transition ratios for the product-ion-poor : activation energy modulation in the absence of distinct neutral losses", Presented at ASMS 2019 (2019)
  33. Scherer M, "Rapid quantification of bile acids and their conjugates in serum by liquid chromatography-tandem mass spectrometry", J Chromatogr B Analyt Technol Biomed Life Sci, 877, pp.3920~3925 (2009)
  34. Peris-Vicente J, "Analytical Separation Science", pp.1757~1808 (2015), Wiley
  35. Hewitt EF, "Implementation of a rapid and automated high performance liquid chromatography method development strategy for pharmaceutical drug candidates", J Chromatogr A, 1107, pp.79~87 (2006)
  36. Dong MW, "Ultra-high-pressure liquid chromatography(UHPLC)in method development", TrAC Trends Anal Chem, 63, pp.21~30 (2014)
  37. Debrus B, "Improved quality-by-design compliant methodology for method development in reversed-phase liquid chromatography", J Pharm Biomed Anal, 84, pp.215~223 (2013)
  38. He X, "Ultra-sensitive measurements of 11-Nor-δ(9)-tetrahydrocannabinol-9-carboxylic acid in oral fluid by microflow liquid chromatography-tandem mass spectrometry using a benchtop quadrupole", orbitrap mass spectrometer, 2012, pp.84, 7643~7647
  39. Christianson CC, "The advantages of microflow LC-MS", MS compared with conventional HPLC-MS, Bioanalysis, pp.2013, 5[DOI]
  40. Remane D, "Recent advances of liquid chromatography-(tandem)mass spectrometry in clinical and forensic toxicology-an update", Clin Biochem, 49, pp.1051~1071 (2016)
  41. Reising AE, "Larger voids in mechanically stable, loose packings of 1.3 μm frictional, cohesive particles: their reconstruction, statistical analysis, and impact on separation efficiency", J Chromatogr A, 1436, pp.118~132 (2016)
  42. Stanley BJ, "On the reproducibility of column performance in liquid chromatography and the role of the packing density", J Chromatogr A, 761, pp.41~51 (1997)
  43. Schwope DM, "Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography-tandem mass spectrometry", Anal Bioanal Chem, 401, pp.1273~1283 (2011)
  44. Saba A, "Quantification of thyroxine and 3,5,3′-triiodo-thyronine in human and animal hearts by a novel liquid chromatography-tandem mass spectrometry method", Horm Metab Res, 46, pp.628~634 (2014)
  45. 유인영, "Evaluation of Stability of Thiopurine Metabolites Using a Validated LC-MS", MS Method, 2018, pp.38(3), 255~260[DOI]
  46. 이새미, "Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Plasma Metanephrines for Differential Diagnosis of Adrenal Incidentaloma", Annals of Laboratory Medicine, 35(5), pp.519~522 (2015), 대한진단검사의학회
  47. Vogeser M, "Candidate reference method for the quantification of circulating 25-hydroxyvitamin D3 by liquid chromatography-tandem mass spectrometry", Clin Chem, 50, pp.1415~1417 (2004)
  48. Kushnir MM, "Liquid chromatography-tandem mass spectrometry assay for androstenedione, dehydroepiandrosterone, and testosterone with pediatric and adult reference intervals", Clin Chem, 56, pp.1138~1147 (2010)
  49. Kim H, "Clinical assay for AFP-L3 by using multiple reaction monitoring-mass spectrometry for diagnosing hepatocellular carcinoma", Clin Chem, 64, pp.1230~1238 (2018)
  50. van den Ouweland JM, "Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparison to radioimmunoassay and automated immunoassay", J Chromatogr B Analyt Technol Biomed Life Sci, 878, pp.1163~1168 (2010)
  51. Lakso HA, "Quantification of methylmalonic acid in human plasma with hydrophilic interaction liquid chromatography separation and mass spectrometric detection", Clin Chem, 54, pp.2028~2035 (2008)
  52. Oßwald A, "Performance of LC-MS", MS and immunoassay based 24-h urine free cortisol in the diagnosis of Cushing’s syndrome, 2019, pp.190, 193~197
  53. Keevil BG, "Salivary testosterone measurement by liquid chromatography tandem mass spectrometry in adult males and females", Ann Clin Biochem, 51, pp.368~378 (2014)
  54. Lenk A, "Solvents : an overlooked ally for liquid chromatography-mass spectrometry", The Column, 14, pp.19~21 (2018)
  55. Rebane R, "Ionization efficiency ladders as tools for choosing ionization mode and solvent in liquid chromatography", mass spectrometry, 2019, pp.33, 1834~1843
  56. Grant RP, "Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens", pp.115~179 (2018), Elsevier
  57. Bennett PK, "Identification of the major endogenous and persistent compounds in plasma, serum and tissue that cause matrix effects with electrospray LC", MS techniques, 2003, ~
  58. Bonfiglio R, "The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds", Rapid Commun Mass Spectrom, 13, pp.1175~1185 (1999)
  59. Little JL, "Liquid chromatography-mass spectrometry", mass spectrometry method development for drug metabolism studies : examining lipid matrix ionization effects in plasma, 2006, pp.833, 219~230
  60. Little JL, "Identification of"known unknowns"utilizing accurate mass data and ChemSpider", J Am Soc Mass Spectrom, 23, pp.179~185 (2012)
  61. Rappold BA, "Special considerations for liquid chromatography-tandem mass spectrometry method development", Clin Lab Med, 38, pp.539~551 (2018)
  62. Clinical and Laboratory Standards Institute, "Interference testing in Clin Chem; approved guideline" (2018), Clinical and Laboratory Standards Institute
  63. Haidar Ahmad IA, "Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances", Analyst, 144, pp.2872~2880 (2019)
  64. Rappold BA, "HILIC-MS", MS method development for targeted quantitation of metabolites : practical considerations from a clinical diagnostic perspective, 2011, pp.34, 3527~3537
  65. Hennion MC, "Solid-phase extraction: method development, sorbents, and coupling with liquid chromatography", J Chromatogr A, 856, pp.3~54 (1999)
  66. Buszewski B, "Past, present, and future of solid phase extraction: a review", Crit Rev Anal Chem, 42, pp.198~213 (2012)
  67. Chambers E, "Systematic and comprehensive strategy for reducing matrix effects in LC", MS, J Chromatogr B Analyt Technol Biomed Life Sci, pp.2007, 852[DOI]
  68. Živanović L, "Application of experimental design in optimization of solid phase extraction of mycophenolic acid and mycophenolic acid glucuronide from human urine and plasma and SPE-RP-HPLC method validation", J Pharm Biomed Anal, 47, pp.575~585 (2008)
  69. Covaci A, "Optimization of the determination of polybrominated diphenyl ethers in human serum using solid-phase extraction and gas chromatography-electron capture negative ionization mass spectrometry", J Chromatogr B Analyt Technol Biomed Life Sci, 827, pp.216~223 (2005)
  70. Yuan L, "Systematic investigation of orthogonal SPE sample preparation for the LC-MS", MS bioanalysis of a monoclonal antibody after pellet digestion, 2013, pp.5, 2379~2391
  71. Nemeškalová A, "Salting out assisted liquid-liquid extraction for liquid chromatography tandem-mass spectrometry determination of amphetamine-like stimulants in meconium", J Pharm Biomed Anal, 172, pp.42~49 (2019)
  72. Tang YQ, "Salting-out assisted liquid-liquid extraction for bioanalysis", Bioanalysis, 5, pp.1583~1598 (2013)
  73. Rashidipour M, "Salt-assisted liquid-liquid extraction coupled with reversed-phase dispersive liquid-liquid microextraction for sensitive HPLC determination of paraquat in environmental and food samples", J Food Meas Char, 13, pp.269~276 (2019)
  74. Tölgyesi Á, "Screening and confirmation of steroids and nitroimidazoles in urine, blood, and food matrices: sample preparation methods and liquid chromatography tandem mass spectrometric separations", J Pharm Biomed Anal, 145, pp.805~813 (2017)
  75. Meunier C, "Development and validation of a method using supported liquid extraction for aldosterone determination in human plasma by LC-MS", MS, 2015, pp.447, 8~15
  76. Jagerdeo E, "Rapid screening for drugs of abuse in biological fluids by ultra high performance liquid chromatography", orbitrap mass spectrometry, 2016, pp.1027, 11~18
  77. Dotsikas Y, "Development of a rapid method for the determination of glimepiride in human plasma using liquid-liquid extraction based on 96-well format micro-tubes and liquid chromatography", tandem mass spectrometry, 2005, pp.19, 2055~2061
  78. Tweed JA, "Automated supported liquid extraction using 2D barcode processing for routine toxicokinetic portfolio support", Bioanalysis, 4, pp.249~262 (2012)
  79. Khan A, "Determination of lipoic acid in human plasma by HPLC-ECD using liquid-liquid and solid-phase extraction: method development, validation and optimization of experimental parameters", J Chromatogr B Analyt Technol Biomed Life Sci, 878, pp.2782~2788 (2010)
  80. Halvorsen TG, "Antibody based affinity capture LC-MS", MS in quantitative determination of proteins in biological matrices, 2017, pp.95, 132~139
  81. Lowenthal MS, "A quantitative LC-MS", MS method for comparative analysis of capture-antibody affinity toward protein antigens, 2011, pp.879, 2726~2732
  82. Lund H, "Epitope analysis and detection of human chorionic gonadotropin(hCG)variants by monoclonal antibodies and mass spectrometry", Tumour Biol, 35, pp.1013~1022 (2014)
  83. Becker JO, "Replacing immunoassays with tryptic digestion-peptide immunoaffinity enrichment and LC-MS", MS, 2012, pp.4, 281~290
  84. van den Broek I, "Evaluation of interspecimen trypsin digestion efficiency prior to multiple reaction monitoring-based absolute protein quantification with native protein calibrators", J Proteome Res, 12, pp.5760~5774 (2013)
  85. Neubert H, "Protein biomarker quantification by immunoaffinity liquid chromatography-tandem mass spectrometry : current state and future vision", Clin Chem, 66, pp.282~301 (2020)
  86. Cobbaert CM, "Towards an SI-traceable reference measurement system for seven serum apolipoproteins using bottom-up quantitative proteomics : conceptual approach enabled by cross-disciplinary", cross-sector collaboration, 2021, pp.67, 478~489
  87. Marcovina SM, "Development of an LC-MS", MS proposed candidate reference method for the standardization of analytical methods to measure lipoprotein(a), 2021, pp.67, 490~499
  88. Nielsen MK, "Determination of olanzapine in whole blood using simple protein precipitation and liquid chromatography-tandem mass spectrometry", J Anal Toxicol, 33, pp.212~217 (2009)
  89. Strathmann FG, "Quantification of 1α, 25-dihydroxy vitamin D by immunoextraction and liquid chromatography-tandem mass spectrometry", Clin Chem, 57, pp.1279~1285 (2011)
  90. Martens-Lobenhoffer J, "Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry", Clin Chem, 52, pp.488~493 (2006)
  91. Polson C, "Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography-tandem mass spectrometry", J Chromatogr B Analyt Technol Biomed Life Sci, 785, pp.263~275 (2003)
  92. Marney LC, "Isopropanol protein precipitation for the analysis of plasma free metanephrines by liquid chromatography-tandem mass spectrometry", Clin Chem, 54, pp.1729~1732 (2008)
  93. Gao H, "Bioanalytical solutions to acetonitrile shortages", Bioanalysis, 2, pp.1627~1640 (2010)
  94. Johnson DW, "Free amino acid quantification by LC-MS", MS using derivatization generated isotope-labelled standards, 2011, pp.879, 1345~1352
  95. Higashi T, "Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry", Anal Bioanal Chem, 378, pp.875~882 (2004)
  96. Phipps WS, "Quantitative amino acid analysis by liquid chromatography-tandem mass spectrometry using low cost derivatization and an automated liquid handler", JIMD Rep, 51, pp.62~69 (2020)
  97. Aronov PA, "Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry", Anal Bioanal Chem, 391, pp.1917~1930 (2008)
  98. Held PK, "Quantitative urine amino acid analysis using liquid chromatography tandem mass spectrometry and aTRAQ® reagents", J Chromatogr B, 879, pp.2695~2703 (2011)
  99. CLSI, "Evaluation of the linearity of quantitative measurement procedures: A statistical approach; approved Guideline" (2003), Clinical and Laboratory Standards Institute
  100. Kushnir MM, "Analysis of catecholamines in urine by positive-ion electrospray tandem mass spectrometry", Clin Chem, 48, pp.323~331 (2002)
  101. Johansen SS, "Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry", J Chromatogr B Analyt Technol Biomed Life Sci, 852, pp.338~344 (2007)
  102. Carobene A, "Creatinine measurement proficiency testing : assignment of matrix-adjusted ID GC-MS target values", Clin Chem, 43, pp.1342~1347 (1997)
  103. Colletti JD, "Sample multiplexing : increased throughput for quantification of total testosterone in serum by liquid chromatography-tandem mass spectrometry", Clin Chem, 66, pp.1181~1189 (2020)
  104. Campbell MT, "When matrix matched calibration systems don’t match truth : distinguishing trueness from accuracy for THC-COOH in urine", Presented at ASMS 2019 (2019)
  105. Kaufmann M, "Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24, 25-dihydroxyvitamin D by LC-MS", MS involving derivatization with DMEQ-TAD, 2014, pp.99, 2567~2574
  106. Li W, "Troubleshooting non-specific binding (NSB) of analyte in a quantitative LC-MS", MS urine assay, 2008, ~
  107. Lame ME, "Quantitation of amyloid beta peptides Aβ(1-38), Aβ(1-40), and Aβ(1-42) in human cerebrospinal fluid by ultra-performance liquid chromatography-tandem mass spectrometry", Anal Biochem, 419, pp.133~139 (2011)
  108. "Guideline on bioanalytical method validation" (2020)[URL]
  109. "Bioanalytical method validation: guidance for industry 2018" (2018)[URL]
  110. Clinical and Laboratory Standards Institute, "Evaluation of detection capability for clinical laboratory measurement procedures" (2012), Clinical and Laboratory Standards Institute
  111. Hoofnagle AN, "Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry", Clin Chem, 54, pp.1796~1804 (2008)
  112. Clarke NJ, "A novel mass spectrometry-based assay for the accurate measurement of thyroglobulin from patient samples containing antithyroglobulin autoantibodies", J Investig Med, 60, pp.1157~1163 (2012)
  113. Kushnir MM, "Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies", Clin Chem, 59, pp.982~990 (2013)
  114. Shuford CM, "More sensitivity is always better : measuring sub-clinical levels of serum thyroglobulin on a μLC-MS", MS system, 2020, pp.15, 29~35
  115. Shiraishi S, "Simultaneous measurement of serum testosterone and dihydrotestosterone by liquid chromatography-tandem mass spectrometry", Clin Chem, 54, pp.1855~1863 (2008)
  116. Kushnir MM, "Performance characteristics of a novel tandem mass spectrometry assay for serum testosterone", Clin Chem, 52, pp.120~128 (2006)
  117. Pauwels S, "Sensitive routine liquid chromatography-tandem mass spectrometry method for serum estradiol and estrone without derivatization", Anal Bioanal Chem, 405, pp.8569~8577 (2013)
  118. Kushnir MM, "High-sensitivity tandem mass spectrometry assay for serum estrone and estradiol", Am J Clin Pathol, 129, pp.530~539 (2008)
  119. Maunsell ZO, "Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3", Clin Chem, 51, pp.1683~1690 (2005)
  120. Shah I, "Misleading measures in Vitamin D analysis : a novel LC-MS", MS assay to account for epimers and isobars, 2011, pp.10, 46~
  121. Wang S, "A fast and simple high-performance liquid chromatography", mass spectrometry method for simultaneous measurement of whole blood tacrolimus and sirolimus, 2005, pp.129, 661~665
  122. Seger C, "A rapid HPLC-MS", MS method for the simultaneous quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human blood samples, 2009, pp.4, 526~534
  123. Koster RA, "Robust, high-throughput LC-MS", MS method for therapeutic drug monitoring of cyclosporine, tacrolimus, everolimus, and sirolimus in whole blood, 2009, pp.31, 116~125
  124. Adam BW, "The stability of markers in dried-blood spots for recommended newborn screening disorders in the United States", Clin Biochem, 44, pp.1445~1450 (2011)
  125. Anderson G, "Determination of product shelf life and activation energy for five drugs of abuse", Clin Chem, 37, pp.398~402 (1991)
  126. Kerns EH, "Accelerated stability profiling in drug discovery", Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Lipophilicity Symposium, pp.281~306 (2006)
  127. Peleg M, "The Arrhenius equation revisited", Crit Rev Food Sci Nutr, 52, pp.830~851 (2012)
  128. Fink HA, "Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men", J Clin Endocrinol Metab, 91, pp.3908~3915 (2006)
  129. Sheehan MT, "Polycystic ovarian syndrome : diagnosis and management", Clin Med Res, 2, pp.13~27 (2004)
  130. Wu FC, "Identification of late-onset hypogonadism in middle-aged and elderly men", N Engl J Med, 363, pp.123~135 (2010)
  131. Sharma A, "Diagnostic thresholds for androgen-producing tumors or pathologic hyperandrogenism in women by use of total testosterone concentrations measured by liquid chromatography-tandem mass spectrometry", Clin Chem, 64, pp.1636~1645 (2018)
  132. Trost LW, "Challenges in testosterone measurement, data interpretation, and methodological appraisal of interventional trials", J Sex Med, 13, pp.1029~1046 (2016)
  133. Substance Abuse and Mental Health Services Administration, "Mandatory Guidelines for Federal Workplace Drug Testing Programs", Federal Register 2008;73:71858-907, ~ (2008)
  134. De Jesús VR, "The newborn screening quality assurance program at the centers for disease control and prevention : thirty-five year experience assuring newborn screening laboratory quality", Int J Neonatal Screen, 1, pp.13~26 (2015)
  135. Trufelli H, "An overview of matrix effects in liquid chromatography-mass spectrometry", Mass Spectrom Rev, 30, pp.491~509 (2011)
  136. Schuhmacher J, "Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry : practical approaches to their elimination", Rapid Commun Mass Spectrom, 17, pp.1950~1957 (2003)
  137. Ismaiel OA, "Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography", mass spectrometry, 2010, pp.878, 3303~3316
  138. Cappiello A, "Overcoming matrix effects in liquid chromatography-mass spectrometry", Anal Chem, 80, pp.9343~9348 (2008)
  139. Baduel C, "Development of sample extraction and clean-up strategies for target and non-target analysis of environmental contaminants in biological matrices", J Chromatogr A, 1426, pp.33~47 (2015)
  140. Carmical J, "The impact of phospholipids and phospholipid removal on bioanalytical method performance", Biomed Chromatogr, 30, pp.710~720 (2016)
  141. Choi BK, "Effect of liquid chromatography separation of complex matrices on liquid chromatography-tandem mass spectrometry signal suppression", J Chromatogr A, 907, pp.337~342 (2001)
  142. Gritti F, "Critical contribution of nonlinear chromatography to the understanding of retention mechanism in reversed-phase liquid chromatography", J Chromatogr A, 1099, pp.1~42 (2005)
  143. Ouakhssase A, "Optimization and validation of a liquid chromatography", tandem mass spectrometry(LC-MS, Heliyon, pp.2019, 5[DOI]
  144. Goeury K, "Data supporting the optimization of liquid chromatography tandem mass spectrometry conditions to analyze EPA-priority hormones and bisphenol A in water samples", Data Brief, 24, pp.103958~ (2019)
  145. Bheemanapally K, "Ultra-high-performance liquid chromatography-electrospray ionization-mass spectrometry for high-neuroanatomical resolution quantification of brain estradiol concentrations", J Pharm Biomed Anal, 191, pp.113606~ (2020)
  146. Davies NH, "Study of overload for basic compounds in reversed-phase high performance liquid chromatography as a function of mobile phase pH", J Chromatogr A, 1119, pp.11~19 (2006)
  147. Riter LS, "Statistical design of experiments as a tool in mass spectrometry", J Mass Spectrom, 40, pp.565~579 (2005)
  148. Moreiras G, "Design of experiments for the optimization of electrospray ionization in the LC-MS", MS analysis of ciguatoxins, 2018, pp.53, 1059~1069
  149. Lickteig A, "Design of optimization : how to improve performance of high-volume clinical LC", MS, Presented at ASMS 2015, pp.2015[DOI]

관련 논문AI추천

Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part II–OperationsRappold Brian A.대한진단검사의학회 · Annals of Laboratory Medicine2022 · 제42권 제5호Calibration Practices in Clinical Mass Spectrometry: Review and RecommendationsCheng Wan Ling, Lim Chun Yee, Loh Tze Ping, Markus Corey, Sethi Sunil Kumar, Tan Rui Zhen대한진단검사의학회 · Annals of Laboratory Medicine2023 · 제43권 제1호임상검사실에서의 액체크로마토그래피-질량분석을 위한 권고안: 제2편. 검사법 검증김세림, 문수영, 박형두, 송상훈, 이경훈, 이상국, 이수연, 최현정대한진단검사의학회 · Laboratory Medicine Online2020 · 제10권 제2호임상검사실에서의 액체크로마토그래피-질량분석을 위한 권고안: 제3편. 질 보증김세림, 문수영, 박형두, 송상훈, 이경훈, 이상국, 이수연, 최현정대한진단검사의학회 · Laboratory Medicine Online2020 · 제10권 제3호임상검사실에서의 액체크로마토그래피-질량분석법에 대한 제언: 도입과 운영김세림, 문수영, 박형두, 송상훈, 이경훈, 이상국, 이수연, 최현정대한진단검사의학회 · Laboratory Medicine Online2020 · 제10권 제1호Use of Liquid Chromatography-Tandem Mass Spectrometry for Clinical Testing in Korean Laboratories: a Questionnaire Survey박형두, 송상훈, 송정한, 윤여민, 이경훈, 이상국, 이수연, 이용화, 전사일, 조성은, 채효진대한진단검사의학회 · Annals of Laboratory Medicine2019 · 제39권 제5호

이 간행물의 다른 논문 (20건)