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임상검사실에서의 액체크로마토그래피-질량분석법에 대한 제언: 도입과 운영

Recommendations for the Use of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part I. Implementation and Management

최현정|이수연|송상훈|이상국|문수영|김세림|박형두|이경훈
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2020.01|Laboratory Medicine Online|제10권 제1호|pp. 1-9|DOI 10.3343/lmo.2020.10.1.1

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참고문헌

키워드

Clinical laboratoryLiquid chromatography-mass spectrometry (LC-MS)Mass spectrometric assay

초록

임상검사실에서 질량분석기를 이용한 검사법은 빠르게 발전하고 있으며 진료에 활용할 수 있는 검사항목도 증가하고 있다. 하지만 질량분석법은 아직까지는 생화학, 면역, 분자진단 등의 다른 측정 방법에 비해서 널리 확산되지는 않았다. 질량분석법을 이용한 검 사를 하기 위해서는 다른 검사와 동일하게 장비, 시약, 시설, 인력 등의 기본요소가 필요하다. 본 논문에서는 질량분석법에 관심이 있으나 도입을 하고 있지 못하거나 도입을 계획하고 있는 임상검사 실에서 액체크로마토그래피-질량분석법 도입시 고려해야 할 사항 을 소개하고자 한다

Abstract

Many types of assays involving mass spectrometry have been developed and applied in clinics. However, mass spectrometry has not been widely implemented yet relative to other measurement methods, including biochemical assays, immunoassays, and molecular diagnostics. Despite its strong advantage as an analytical method, many laboratory physicians and clinical laboratories are unwilling to introduce it. Fundamental elements, such as instruments, reagents, facilities, skilled human resources are required to implement mass spectrometry. This review contains considerations for the introduction of liquid chromatography-mass spectrometry to support the clinical laboratories interested in or planning to implement mass spectrometry.

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