백하수오와 속단 추출물의 뼈 골격 성장과 IGF-I 생성 촉진 효과
Effects of Cynanchum wilfordii and Phlomis umbrosa Extracts on Bone Growth and Serum Insulin Like Growth Factor-I
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This study examined the efficacies of Cynanchum wilfordii and Phlomis umbrosa extracts on serum insulin like growth factor-I (IGF-I) and bone growth by raising rats in vivo. C. wilfordii and P. umbrosa extracts significantly increased serum IGF-I by 42% and 22% than the control, respectively. Treatment with α-amylase when manufacturing these extracts remarkably increased the concentration of IGF-I by 63% and 36% above the control, respectively. This meant that these extracts, especially α- amylase treated extracts, maintained a higher level of IGF-I secretion in the treated groups. In addition, increases of 6% in femur length were found after 8 weeks of oral administration with these extracts. These results indicate that C. wilfordii and P. umbrosa extracts have beneficial effects on bone growth via IGF-I.
Abstract
This study examined the efficacies of Cynanchum wilfordii and Phlomis umbrosa extracts on serum insulin like growth factor-I (IGF-I) and bone growth by raising rats in vivo. C. wilfordii and P. umbrosa extracts significantly increased serum IGF-I by 42% and 22% than the control, respectively. Treatment with α-amylase when manufacturing these extracts remarkably increased the concentration of IGF-I by 63% and 36% above the control, respectively. This meant that these extracts, especially α- amylase treated extracts, maintained a higher level of IGF-I secretion in the treated groups. In addition, increases of 6% in femur length were found after 8 weeks of oral administration with these extracts. These results indicate that C. wilfordii and P. umbrosa extracts have beneficial effects on bone growth via IGF-I.
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