조피볼락, Sebastes schlegeli에 경구투여된 oxolinic acid의 약물동태에 미치는 수온의 영향
Effects of temperature on pharmacokinetics of oxolinic acid in black rockfish, Sebastes schlegeli following oral administration
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Oxolinic acid를 사육수온(13±1.5℃, 23±1.5℃)에 따라서 조피볼락(평균체중 500 g)에 60 ㎎/㎏의 농도로1회 경구 투여한 다음, 경시적인 혈청내 잔류농도를분석하였다. 23±1.5℃의 경우 투여 후 30시간째(0.60㎍/㎖)에 최대혈중농도에 도달하였다. 13±1.5℃의 경우 투여 후 10시간째(2.22 ㎍/㎖) 최대혈중농도에 도달하였다. OA의 조피볼락 혈중내 흡수양상과 소실정도는 사육수온에 크게 영향을 받았다. Two-compartment model로 해석하여 WinNonlin program을 이용, 약물동태학적 매개변수(parameter)를 조사하였다. 23±1.5℃의 경우, 혈장농도－시간곡선하 면적(AUC)은 42.16㎍ㆍh/㎖, 혈중최고농도의 도달시간(Tmax)은 26.13h, 혈중최고농도(Cmax)는 0.43 ㎍/㎖, 예상약물소실시간(Et)은 230시간으로 계산되었다. 13±1.5℃의 경우, AUC는 131.98 ㎍ㆍh/㎖, Tmax는 8.81 h, Cmax는2.04 ㎍/㎖, Et는 492시간으로 계산되었다.
Abstract
Effects of temperature (13±1.5℃, 23±1.5℃) on the pharmacokinetic properties of oxolinic acid (OA) were studied after oral administration to cultured black rockfish, Sebastes schlegeli. Serum concentrations of OA were determined using HPLC-UV detector after a single dosage of 60 ㎎/㎏ body weight (average about 500 g). The peak serum concentrations of OA at 23±1.5℃ and 13±1.5℃ were 0.60 ㎍/㎖ at 30 h and 2.22 ㎍/㎖ at 10 h post-dose, respectively. Better absorption of OA was noted at 13±1.5℃ compared to 23±1.5℃. The elimination of OA from serum was considerably faster at 23±1.5℃ than at 13±1.5℃. Both absorption and elimination of OA were affected significantly by temperature. The kinetic profile of absorption, distribution and elimination of OA in serum was analyzed by fitting to a two compartment model, with WinNonlin program. The AUC, Tmax and Cmax at 23±1.5℃ were 42.16 ㎍․h/㎖, 26.13 h and 0.43 ㎍/㎖, respectively. The AUC, Tmax and Cmax at 13±1.5℃ were 131.98 ㎍․h/㎖, 8.81 h and 2.04 ㎍/㎖, respectively.
참고문헌 (29)
- Björklund, H., "Temperature-related absorption and excretion of oxytetracycline in rainbow trout (Salmo gairdneri R.)", Aquaculture, 84, pp.363~372 (1990)
- Coyne, R., "Attempt to validate breakpoint MIC values estimated from pharmacokinetic data obtained during oxolinic acid therapy of winter ulcer disease in Atlantic salmon (Salmo salar)", Aquaculture, 238, pp.51~66 (2004)
- Hustvedt, S.O., "Distribution and elimination of oxolinic acid in rainbow trout (Oncorhynchus mykiss Walbaum) after a single rapid intravascular injection", Aquaculture, 92, pp.297~303 (1991)
- JinWooKim, "Effects of Temperature on the Pharmacokinetics of Ciprofloxacin in the Cultured Black Rockfish(Sebastes schlegeli) and Olive Flounders(Paralichthys olivaceus)", Fisheries and Aquatic Sciences, 5(3), pp.200~205 (2002), 한국수산과학회
- Poher, I., "Pharmacokinetics of oxolinic acid in sea bass, Dicentrarchus Iabrax (L., 1758), after a single rapid intravascular injection", J. Vet. Pharmacol. Therap., 20, pp.267~275 (1997)
- Rigos, G., "Temperature-dependent pharmacokinetics and tissue distribution of oxolinic acid in sea bass, Dicentrarchus labrax L., after a single intravascular injection", Aquacult. Res., 25, pp.401~408 (2002)
- Rigos, G., "Pharmacokinetics of oxolinic acid in gilthead sea bream, Sparus aurata L", J. Fish. Dis., 25, pp.401~408 (2002)
- Rigos, Tyrpenou, A.E., "The kinetic profile of oxolinic acid in sharpsnout sea bream, Diplodus puntazzo (Cetti 1777)", Aquacult. Res., 35, pp.1299~1304 (2004)
- Rogstad, A., "Pharmacokinetics and bioavailability of flumequine and oxolinic acid after various routes of administration to Atlantic salmon in seawater", Aquaculture, 110, pp.207~220 (1993)
- Samuelson, O.B., "Multiple dose pharmacokinetic study of oxolinic acid in cod, Gadus morhua L", Aquacult. Int., 14, pp.443~450 (2006)
- Samuelson, O.B., "A single-dose pharmacokinetic study of oxolinic acid ester, in cod, Gadus morhua L., held in sea water at 8℃ and in vitro antibacterial activity of oxolinic acid against Vibrio anguillarum strains isolated from diseased cod", J. Fish Dis., 26, pp.339~347 (2003)
- Samuelson, O.B., "A single-dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in Atlantic halibut, Hippoglossus hippoglossus L., held in sea water at 9℃", J. Fish Dis., 22, pp.13~23 (1999)
- Samuelson, O.B., "Absorption, tissue distribution and excretion of flumequine and oxolinic acid in corkwing wrasse (Symphodus melops) following a single intraperitoneal injection or bath treatment", J. Vet. Pharmacol. Therap., 24, pp.111~116 (2001)
- Samuelson, O.B., "Single-dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in atlantic salmon (Salmo salar) held in sea water and in vitro antibacterial activity of against Aeromonas salmonicida", Aquaculture, 187, pp.213~224 (2000)
- Sangrungruang, K., "Development of method for forced oral administration of xenobiotics in shrimp", Fish. Sci., 70, pp.463~466 (2004)
- Treves-Brown, K.M., "Tetracyclines. In Applied Fish Pharmacology", pp.64~82 (2000), Kluwer Academic Publishers
- Uno, K., "Pharmacokinetics of oxolinic acid and oxytetracycline in kuruma shrimp, Penaeus japonicus", Aquaculture, 230, pp.1~11 (2004)
- Uno, K., "Pharmacokinetics of oxolinic acid in black tiger shrimp, Penaeus monodon Fabricius, and the effect of cooking on residues", Aquacult. Res., 37, pp.826~833 (2006)
- Samuelson, O.B., "A single-dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in Atlantic halibut, Hippoglossus hippoglossus L., held in sea water at 9℃", J. Fish Diseas., 22, pp.13~23 (1999)
- Zhang, Q., "Pharmacokinetics and residue elimination of oxytetracycline in grass carp, Ctenopharyngodon idellus", Aquaculture, 272, pp.140~145 (2007)
- 김명석, "수온과 세균 감염이 나일틸라피아(Oreochromis niloticus)의 oxolinic acid 흡수와 배설에 미치는 영향", 한국어병학회지, 31, pp.677~684 (1998)
- 손맹현, "조피볼락 양식 표준지침서" (2007), 국립수산과학원 양식관리팀
- 옥영수, "조피볼락의 최근 생산 동향과 시사점", 월간해양수산, 285, pp.55~68 (1997)
- 정승희, "병용항균제의 어류질병 세균에 대한 시험관내 항균활성", 한국어병학회지, 13, pp.45~51 (2000)
- 정현도, "향어에서의 oxolinic acid 흡수와 배설속도", 한국어병학회지, 5, pp.135~142 (1992)
- 정승희, "Oxytetracycline의 약욕 및 경구투여에 따른 넙치 (Paralichthys olivaceus) 체내 약물동태학적 특성", 한국어병학회지, 21(2), pp.107~117 (2008), 한국어병학회
- 정승희, "Oxolinic acid의 경구투여, 주사 및 약욕에 따른 넙치, Paralichthys olivaceus 체내 약물동태학적 특성", 한국어병학회지, 22(2), pp.125~135 (2009), 한국어병학회
- 정승희, "넙치, Paralichthys olivaceus에 nalidixic acid, piromidic acid, oxolinic acid의 경구투여 약물동태에 미치는 수온의 영향", 한국어병학회지, 23(1), pp.57~67 (2010), 한국어병학회
- 최민순, "잉어에 있어서 Quinolones(Ciprofloxacin, Norfloxacin 및 Oxolinic acid)의 경구투여에 따른 장기내 분포상", 한국어병학회지, 18(3), pp.269~276 (2005), 한국어병학회