Oxytetracycline을 근육 주사한 넙치 (Paralichthys olivaceus)의 약물동태학적 특성
Pharmacokinetics of oxytetracycline in olive flounder (Paralichthys olivaceus) by intramuscular injection
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초록
옥시테트라사이클린 (OTC)을 넙치 (평균체중 600 g)에 1회 근육 주사 (12.5, 25 및 50 ㎎/㎏ body weight)한 다음, 경시적 (3시간~360시간)인 혈장내 OTC의 잔류농도를 분석하였다. 25 및 50 ㎎/㎏ 시험구에서 투여 5시간째 각각 0.99 및 1.49 ㎍/㎖로 최대혈중농도를 나타내었으나, 12.5 ㎎/㎏ 시험구는 투여 10시간째 0.35 ㎍/㎖ 로 최대혈중농도를 나타내었다. 모든 시험구는 투여 360시간째 혈중에서 OTC가 검출되지 않 았다. OTC의 넙치 체내 약물 혈중농도 측정결 과를 바탕으로 1- compartment model로 Win- Nonlin program을 이용하여 OTC의 흡수, 배설, 반감기 등 약물동태학적 매개변수 (parameter)를 조사하였다. 12.5, 25 및 50 ㎎/㎏을 근육 주사한 경우, 혈장농도-시간곡선하 면적 (AUC)은 각각 24.9, 44.67 및 50.45 ㎍∙h/㎖, 약물의 반감기 (T1/2)는 각각 0.42, 0.59 및 0.41 h, 혈중최고농도 의 도달시간 (Tmax)은 8.46, 6.34 및 2.66 h, 혈중 최고농도 (Cmax)는 0.30, 0.63 및 1.13 ㎕/㎖로 계 산되었다.
Abstract
The pharmacokinetic properties of oxytetracycline (OTC) were studied after intramuscular injection to cultured olive flounder, Paralichthys olivaceus. Plasma concentrations of OTC were determined after dosage of 12.5, 25 and 50 ㎎/㎏ body weight in olive flounder (average 600 g, 23±1℃). Plasma samples were taken at 3, 5, 10, 15, 24, 32, 48, 72, 120, 168, 240 and 360 h post-dose. With 25 and 50 ㎎/㎏, the peak plasma concentrations of OTC, which attained at 5 h post-dose, were 0.99 and 1.49 ㎍/㎖, respectively. However, the peak plasma concentration of 12.5 ㎎/㎏ was 0.35 ㎍/㎖ after 10 h post-dose. Plasma concentrations of OTC were not measurable at 360 h post-dose in all doses. The kinetic profile of absorption, distribution and elimination of OTC in plasma were analyzed fitting to a 1-compartment model by Win- Nonlin program. The following parameters were calculated for 12.5, 25 and 50 ㎎/㎏ body weight, respectively: AUC (the area under the concentration-time curve)=24.98, 44.67 and 50.45 ㎍∙h/㎖; T1/2 (half-life)=0.42, 0.59 and 0.41 h; Tmax (time for maximum concentration)=8.46, 6.34 and 2.66 h; Cmax (maximum concentration)=0.30, 0.63 and 1.13 ㎕/㎖.
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