조피볼락, Sebastes schlegeli에 경구투여된 nalidixic acid 및 piromidic acid의 약물동태에 미치는 수온의 영향
Effect of temperature on pharmacokinetics of nalidixic acid and piromidic acid in black rockfish Sebastes schlegeli following oral administration
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Effects of temperature (13±1.5℃, 23±1.5℃) on the pharmacokinetic properties of nalidixic acid (NA) and piromidic acid (PA) were studied after oral administration to cultured black rockfish, Sebastes schlegeli. Serum concentrations of NA and PA were determined using HPLC-UV detector after a single dosage of 60 ㎎/㎏ body weight. At 23±1.5℃, the peak serum concentrations of NA and PA, which attained at 24 h post-dose, were 5.87 and 0.43 ㎍/㎖, respectively. At 13±1.5℃, the peak serum concentrations of NA and PA, which attained at 10 h post-dose, were 6.22 and 1.57 ㎍/㎖, respectively. Better absorption of PA was noted at 13±1.5℃ compared to 23±1.5℃. However, absorption of NA was not affected significantly by temperature. The elimination of NA and PA from serum of black rockfish was considerably faster at 23±1.5℃ than at 13±1.5℃. The kinetic profile of absorption, distribution and elimination of NA and PA in serum were analyzed by fitting to a one compartment model, with WinNonlin program. The AUC, T_(1/2), T_(max) and C_(max), respectively, were: 161.25 ㎍․h/㎖, 0.15 h, 12.29 h and 8.91 ㎍/㎖ at 23±1.5℃, and 134.12 ㎍․h/㎖, 0.18 h, 8.79 h and 5.00 ㎍/㎖ at 13±1.5℃ with NA; 41.57 ㎍․h/㎖, 0.58 h, 8.24 h and 0.21 ㎍/㎖ at 23±1.5℃, and 40.36 ㎍․h/㎖, 0.59 h, 5.04 h and 1.20 ㎍/㎖ at 13±1.5℃ with PA.
Abstract
Effects of temperature (13±1.5℃, 23±1.5℃) on the pharmacokinetic properties of nalidixic acid (NA) and piromidic acid (PA) were studied after oral administration to cultured black rockfish, Sebastes schlegeli. Serum concentrations of NA and PA were determined using HPLC-UV detector after a single dosage of 60 ㎎/㎏ body weight. At 23±1.5℃, the peak serum concentrations of NA and PA, which attained at 24 h post-dose, were 5.87 and 0.43 ㎍/㎖, respectively. At 13±1.5℃, the peak serum concentrations of NA and PA, which attained at 10 h post-dose, were 6.22 and 1.57 ㎍/㎖, respectively. Better absorption of PA was noted at 13±1.5℃ compared to 23±1.5℃. However, absorption of NA was not affected significantly by temperature. The elimination of NA and PA from serum of black rockfish was considerably faster at 23±1.5℃ than at 13±1.5℃. The kinetic profile of absorption, distribution and elimination of NA and PA in serum were analyzed by fitting to a one compartment model, with WinNonlin program. The AUC, T_(1/2), T_(max) and C_(max), respectively, were: 161.25 ㎍․h/㎖, 0.15 h, 12.29 h and 8.91 ㎍/㎖ at 23±1.5℃, and 134.12 ㎍․h/㎖, 0.18 h, 8.79 h and 5.00 ㎍/㎖ at 13±1.5℃ with NA; 41.57 ㎍․h/㎖, 0.58 h, 8.24 h and 0.21 ㎍/㎖ at 23±1.5℃, and 40.36 ㎍․h/㎖, 0.59 h, 5.04 h and 1.20 ㎍/㎖ at 13±1.5℃ with PA.
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