Sulfadimethoxine의 경구 투여에 따른 넙치, Paralichthys olivaceus 혈액 및 간에서의 잔류량 변화
Residues of sulfadimethoxine in blood and liver of cultured olive flounder Paralichthys olivaceus by oral administration
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초록
설파디메톡신(sulfadimethoxine, SDM)을 넙치(평균 체중 100±20 g, 20±1.0℃)에 대하여 400 ㎎/㎏의농도로 1회 경구 투여한 다음, 혈장과 간에서 시간경과에 따른 잔류량을 HPLC로써 분석하였다. SDM 을 넙치의 조직에 2~50 ppm의 농도가 되도록 첨가한결과, 평균 회수율은 혈장에서 92.24~93.62%, 간에서88.34~91.90%의 범위로 나타났으며, 이 분석법의 검출한계는 0.05 ppm이었다. SDM은 투여한 후, 1시간째에 혈액(402.64±59.66 ㎍/㎖)과 간(238.18±54.00 ㎍/㎖)에서 모두 최고농도로 분포하였다. 이후 SDM은빠른 속도로 배설되었으며, 480시간째는 혈장과 간에서 검출되지 않았다.
Abstract
The residue levels of sulfadimethoxine (SDM) was studied after oral administration to cultured olive flounder, Paralichthys olivaceus at 20±1.0℃. The concentrations of SDM in the plasma and liver were determined by HPLC-UV detector after a single dosage of 400 ㎎/㎏ body weight. The average recoveries of SDM in spiked samples between 2∼50 ppm were 92.24∼93.62% for plasma and 88.34∼91.90% for liver. Limit of detection for SDM was 0.05 ppm by using this method. Samples were taken at 1 h, 6 h, 12 h, 24 h, 48 h, 72 h, 168 h, 240 h, 336 h and 480 h post-dose. The peak plasma and liver concentrations of SDM, which attained at 1 h post-dose, was 402.64±59.66 ㎍/㎖ and 238.18±54 ㎍/g, respectively. Thereafter, it's elimination from both tissues was considerably faster following process of time. Their concentrations of SDM were not measurable at 480 h post-dose. Based on this results, dosage and withdrawal times for SDM could be used when it is prescribed with SDM in olive flounder.
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