Interactions of Vascular Risk Factors and Apolipoprotein E4 on Geriatric Depression
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초록
목적: 혈관성 위험인자 및 아포지단백 E ε4 유전자형(APOE4)과 노년기 우울증 간의 연관성은 명확하지 않다. 본 연구는 노년기 우울증의 발병에 있어서 혈관성 위험인자와 APOE4의 상호작용이 있는지 조사하고자 하였다.방법: 지역사회에 거주하는 732명의 65세 이상 노인들을 대상으로 우울증을 조사하였고, 혈관성 위험인자에 대한 정보를 수집하고 검사를 시행하였다. 또한 APOE 유전자형, 인구학적 특성, 신체건강, 인지기능을 평가하였다.결과: 뇌졸중과 낮은 고밀도지단백 치가 노년기 우울증과 독립적 연관성이 있었다. 이들 간의 연관성은 APOE4를 가진 경우에만 유의하였으나, 상호작용은 통계적 유의수준에 미치지 못하였다.Conclusion: 혈관성 위험인자와 노년기 우울증 간의 연관성은 APOE4가 존재하는 경우에 보다 두드러졌으나, 이 주제에 대한 확실한 결론에 이르기 위해서는 전향적 연구가 필요하다.
Abstract
Objective: Associations of vascular risk / disease or apolipoprotein E ε4 (APOE4) with geriatric depression has been unclear at a population level. This study aimed to evaluate whether there would be interactions of vascular risk / disease and APOE4 on depression in a Korean elderly population.Methods: 732 community residents aged 65 or over were assessed for depression (GMS), information on vascular risk / disease (reported stroke, transient ishemic attack, heart disease, hypertension, diabetes, smoking), examinations for vascular risk / disease (blood pressure, blood tests for glucose and lipid profiles, body size), APOE genotypes, demographic characteristics (age, gender, education), physical health, and cognitive function (MMSE).Results: Previous stroke and lower level of high density lipoprotein (HDL) cholesterol were significantly associated with geriatric depression independent of demographic characteristics, physical illnesses, and cognitive function. These associations were statistically significant only in those with APOE4, although the interaction terms didnt reach to statistical significance.Conclusion: Associations between vascular risk / disease and geriatric depression might be more prominent in those with APOE4. However further research would be needed to clarify this issue.
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