알츠하이머병에서 우울 증상과 고혈압의 관계
Hypertension is Associated with Depressive Symptoms in Alzheimer’s Disease
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Objective：To explore the effect of vascular risk factors to the depressive symptom in Alzheimer’s disease (AD). Methods：Retrospective chart reviews were performed for the patients, who underwent comprehensive neuropsychiatric assessment in the geriatric psychiatric clinic in the period between May of 2015 and January of 2017. Patients with moderate to severe stage of AD, neurological comorbidities and major psychiatric disorders were excluded to minimize the confounding factors. Sixty five newly diagnosed early AD patients were included and bisected by the cutoff point of 5 in the short version of the Geriatric Depression Scale. Comparisons were done between two groups for vascular risk factors and other relevant clinic-demographic variables. Binary logistic regression analysis was additionally performed to estimate the effect of hypertension to the depressive symptoms. Results：Among the investigated vascular risk factors, hypertension was associated with depressive symptom in the early AD patients. In the logistic regression, odd ratio of hypertension for depression was 4.34 (95% confidence interval 1.47-12.79). Conclusion：Depressive symptoms in the AD patients were associated with hypertension. Therefore, managing this vascular factor in the middle age may not only decrease the risk for neurovascular disorders, but also provide additional benefits in curtailing depression in AD.
Abstract
Objective：To explore the effect of vascular risk factors to the depressive symptom in Alzheimer’s disease (AD). Methods：Retrospective chart reviews were performed for the patients, who underwent comprehensive neuropsychiatric assessment in the geriatric psychiatric clinic in the period between May of 2015 and January of 2017. Patients with moderate to severe stage of AD, neurological comorbidities and major psychiatric disorders were excluded to minimize the confounding factors. Sixty five newly diagnosed early AD patients were included and bisected by the cutoff point of 5 in the short version of the Geriatric Depression Scale. Comparisons were done between two groups for vascular risk factors and other relevant clinic-demographic variables. Binary logistic regression analysis was additionally performed to estimate the effect of hypertension to the depressive symptoms. Results：Among the investigated vascular risk factors, hypertension was associated with depressive symptom in the early AD patients. In the logistic regression, odd ratio of hypertension for depression was 4.34 (95% confidence interval 1.47-12.79). Conclusion：Depressive symptoms in the AD patients were associated with hypertension. Therefore, managing this vascular factor in the middle age may not only decrease the risk for neurovascular disorders, but also provide additional benefits in curtailing depression in AD.
참고문헌 (18)
- You Joung Kim, "Prevalence and Trends of Dementia in Korea: A Systematic Review and Meta-Analysis", Journal of Korean Medical Science, 29(7), pp.903~912 (2014), 대한의학회
- Kim KW, "A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea", J Alzheimers Dis, 23, pp.281~291 (2011)
- 오병훈, "치매의 행동•정신 증상 진단 및 관리", 대한의사협회지, 52(11), pp.1048~1054 (2009), 대한의사협회
- 김태유, "알쯔하이머병의 진행 정동에 따른 행동심리적 증상의 변화", 대한신경과학회지, 22(1), pp.34~39 (2004), 대한신경과학회
- Tsuno N, "What is the association between depression and Alzheimer’s disease?", Expert Rev Neurother, 9, pp.1667~1676 (2009)
- Kim BS, "Clinical manifestations of depressive symptoms in Korean elderly", J Korean Geriatr Psychiatry, 7, pp.163~177 (2003)
- 강유미, "기억력 저하를 호소하는 노인 우울증과 기억성 경도인지장애 환자에서 인지기능 특성의 비교", 노인정신의학, 15(1), pp.38~44 (2011), 대한노인정신의학회
- Notzon S, "Late-onset depression: pathophysiology, diagnostics and treatment", Nervenarzt, 87, pp.1017~1029 (2016)
- Köhler S, "Depression, vascular factors, and risk of dementia in primary care: a retrospective cohort study", J Am Geriatr Soc, 63, pp.692~698 (2015)
- Alexopoulos GS, "Vascular disease, depression, and dementia", J Am Geriatr Soc, 51, pp.1178~1180 (2003)
- Barnes DE, "Depressive symptoms, vascular disease, and mild cognitive impairment:findings from the Cardiovascular Health Study", Arch Gen Psychiatry, 63, pp.273~279 (2006)
- Mitchell AJ, "Diagnostic validity and added value of the Geriatric Depression Scale for depression in primary care: a meta-analysis of GDS30 and GDS15", J Affect Disord, 125, pp.10~17 (2010)
- Yesavage JA, "9", Geriatric Depression Scale (GDS), 1986, pp.5, 165~173
- Almeida OP, "Short versions of the Geriatric Depression Scale: a study of their validity for the diagnosis of a major depressive episode according to ICD-10 and DSM-IV", Int J Geriatr Psychiatry, 14, pp.858~865 (1999)
- Santos CY, "Pathophysiologic relationship between Alzheimer’s disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis", Alzheimers Dement (Amst), 7, pp.69~87 (2017)
- Kisler K, "Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease", Nat Rev Neurosci, 18, pp.419~434 (2017)
- Lim HK, "Regional cortical thickness and subcortical volume changes are associated with cognitive impairments in the drug-naive patients with late-onset depression", Neuropsychopharmacology, 37, pp.838~849 (2012)
- Portegies ML, "Cerebrovascular disease", Handb Clin Neurol, 138, pp.239~261 (2016)