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자살을 시도한 우울증 환자에서 혈장 ß -Nerve Growth Factor 농도의 변화

Alteration of plasma ？-Nerve Growth Factor concentration in depressed patients with suicidal attempt

권영준|원성두|양종철|이분희|김용구|심세훈
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2006.05|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제13권 제2호|pp. 18-25

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참고문헌

키워드

DepressionSuicideNGFNeurotrophinRisk-rescue ratingLethality Suicide Attempt Rating Scale.
주제분류정신과학

초록

ObjectNerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt.MethodsThe subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). The severity of the suicidal behavior was evaluated by Weisman and Wordens risk-rescue rating (RRR) system and the Lethality Suicide Attempt Rating Scale (LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay (ELISA) method.

Abstract

ObjectNerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt.MethodsThe subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). The severity of the suicidal behavior was evaluated by Weisman and Wordens risk-rescue rating (RRR) system and the Lethality Suicide Attempt Rating Scale (LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay (ELISA) method.

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