공황장애 환자에서의 Brain-Derived Neurotrophic Factor 변화
Alteration of Brain-Derived Neurotrophic Factor Levels in Panic Disorder
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in neurogenesis and synaptic plasticity, has been implicated in the pathophysiology of several neuropsychiatric disorders. However, there have been no consistent findings regarding BDNF levels in panic disor¬der. In this study, we investigated plasma BDNF levels in panic disorder, and evaluated whether there is an association between plasma BDNF levels and severity of symptoms of panic disorder. Methods Plasma BDNF levels were measured in 110 panic disorder patients and 110 normal control subjects using the enzyme-linked immunosorbent assay. The severity of symptoms of panic disorder was determined using the Panic Disorder Severity Scale, Acute Panic Inventory, Agoraphobic Cognition Questionnaire, and Hamilton Anxiety Rating Scale. Results The mean plasma BDNF levels of patients with panic disorder were significantly lower compared with those of control subjects (192.50 pg/mL vs. 693.75 pg/mL). No significant associa¬tion was observed between plasma BDNF levels and the severity of symptoms of panic disorder. Conclusion These results suggest that BDNF may play a potential role in the pathophysiology of panic disorder.
Abstract
Objectives Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in neurogenesis and synaptic plasticity, has been implicated in the pathophysiology of several neuropsychiatric disorders. However, there have been no consistent findings regarding BDNF levels in panic disor¬der. In this study, we investigated plasma BDNF levels in panic disorder, and evaluated whether there is an association between plasma BDNF levels and severity of symptoms of panic disorder. Methods Plasma BDNF levels were measured in 110 panic disorder patients and 110 normal control subjects using the enzyme-linked immunosorbent assay. The severity of symptoms of panic disorder was determined using the Panic Disorder Severity Scale, Acute Panic Inventory, Agoraphobic Cognition Questionnaire, and Hamilton Anxiety Rating Scale. Results The mean plasma BDNF levels of patients with panic disorder were significantly lower compared with those of control subjects (192.50 pg/mL vs. 693.75 pg/mL). No significant associa¬tion was observed between plasma BDNF levels and the severity of symptoms of panic disorder. Conclusion These results suggest that BDNF may play a potential role in the pathophysiology of panic disorder.
참고문헌 (58)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" (1994), American Psychiatric Association
- Katon WJ, "Clinical practice. Panic disorder", N Engl J Med, 354, pp.2360~2367 (2006)
- Spitzer RL, "Health-related quality of life in primary care patients with mental disorders. Results from the PRIME-MD 1000 Study", JAMA, 274, pp.1511~1517 (1995)
- Markowitz JS, "Quality of life in panic disorder", Arch Gen Psychiatry, 46, pp.984~992 (1989)
- Walker EA, "Psychiatric diagnoses, sexual and physical victimization, and disability in patients with irritable bowel syndrome or inflammatory bowel disease", Psychol Med, 25, pp.1259~1267 (1995)
- Katon WJ, "Psychiatric illness in patients with chronic fatigue and those with rheumatoid arthritis", J Gen Intern Med, 6, pp.277~285 (1991)
- Coryell W, "Excess mortality in panic disorder. A comparison with primary unipolar depression", Arch Gen Psychiatry, 39, pp.701~703 (1982)
- Zane RD, "Panic disorder and emergency services utilization", Acad Emerg Med, 10, pp.1065~1069 (2003)
- Rubin HC, "Quality of well being in panic disorder: the assessment of psychiatric and general disability", J Affect Disord, 57, pp.217~221 (2000)
- Nesse RM, "Adrenergic function in patients with panic anxiety", Arch Gen Psychiatry, 41, pp.771~776 (1984)
- Maddock RJ, "Evidence that decreased function of lymphocyte beta adrenoreceptors reflects regulatory and adaptive processes in panic disorder with agoraphobia", Am J Psychiatry, 150, pp.1219~1225 (1993)
- Maddock RJ, "Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder", J Affect Disord, 29, pp.27~32 (1993)
- Kent JM, "Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety", Biol Psychiatry, 44, pp.812~824 (1998)
- Klein DF, "False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis", Arch Gen Psychiatry, 50, pp.306~317 (1993)
- Papp LA, "Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects", Am J Psychiatry, 154, pp.1557~1565 (1997)
- Pavlov PI, "Conditioned reflexes: an investigation of the physiological activity of the cerebral cortex", Ann Neurosci, 17, pp.136~141 (2010)
- Yeragani VK, "Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate", Psychiatry Res, 46, pp.89~103 (1993)
- Numata S, "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms", Neurosci Lett, 401, pp.1~5 (2006)
- Lin PY, "State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study", Neurosci Lett, 466, pp.139~143 (2009)
- Shim SH, "Increased levels of plasma brain-derived neurotrophic factor (BDNF)in children with attention deficit-hyperactivity disorder (ADHD)", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.1824~1828 (2008)
- Gonul AS, "Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients", Eur Arch Psychiatry Clin Neurosci, 255, pp.381~386 (2005)
- Karege F, "Decreased serum brain-derived neurotrophic factor levels in major depressed patients", Psychiatry Res, 109, pp.143~148 (2002)
- Shimizu E, "Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants", Biol Psychiatry, 54, pp.70~75 (2003)
- Brunoni AR, "A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression", Int J Neuropsychopharmacol, 11, pp.1169~1180 (2008)
- Lee BH, "Decreased plasma BDNF level in depressive patients", J Affect Disord, 101, pp.239~244 (2007)
- Kim YK, "Low plasma BDNF is associated with suicidal behavior in major depression", Prog Neuropsychopharmacol Biol Psychiatry, 31, pp.78~85 (2007)
- David DJ, "Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety", depression, 2009, pp.62, 479~493
- Chen ZY, "Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior", Science, 314, pp.140~143 (2006)
- Maina G, "Serum levels of brain-derived neurotrophic factor in drug-naïve obsessive-compulsive patients: a case-control study", J Affect Disord, 122, pp.174~178 (2010)
- Rios M, "Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity", Mol Endocrinol, 15, pp.1748~1757 (2001)
- Nibuya M, "Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments", J Neurosci, 15, pp.7539~7547 (1995)
- Suliman S, "Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis.", Front Integr Neurosci, 7, pp.55~ (2013)
- Kobayashi K, "Serum brain-derived neurotrophic factor (BDNF)levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy", Prog Neuropsychopharmacol Biol Psychiatry, 29, pp.658~663 (2005)
- Fujimura H, "Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation", Thromb Haemost, 87, pp.728~734 (2002)
- Rosenfeld RD, "Purification and identification of brain-derived neurotrophic factor from human serum", Protein Expr Purif, 6, pp.465~471 (1995)
- Pan W, "Transport of brain-derived neurotrophic factor across the blood-brain barrier", Neuropharmacology, 37, pp.1553~1561 (1998)
- 이중서, "한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구", 신경정신의학, 44(4), pp.456~465 (2005), 대한신경정신의학회
- Shear MK, "Multicenter collaborative panic disorder severity scale", Am J Psychiatry, 154, pp.1571~1575 (1997)
- Kim JB, "Development of the Korean version of the Panic Disorder Severity Scale", Korean J Psychopathol, 10, pp.140~151 (2001)
- Dillon DJ, "Measurement of lactate-induced panic and anxiety", Psychiatry Res, 20, pp.97~105 (1987)
- Chambless DL, "Assessment of fear of fear in agoraphobics: the body sensations questionnaire and the agoraphobic cognitions questionnaire", J Consult Clin Psychol, 52, pp.1090~1097 (1984)
- Hamilton M, "The assessment of anxiety states by rating", Br J Med Psychol, 32, pp.50~55 (1959)
- Piccinni A, "Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments", J Affect Disord, 105, pp.279~283 (2008)
- Radka SF, "Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay", Brain Res, 709, pp.122~301 (1996)
- Laghrissi-Thode F, "Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease", Biol Psychiatry, 42, pp.290~295 (1997)
- Musselman DL, "Exaggerated platelet reactivity in major depression", Am J Psychiatry, 153, pp.1313~1317 (1996)
- Göğçegöz Gül I, "Decreased mean platelet volume in panic disorder", Neuropsychiatr Dis Treat, 10, pp.1665~1669 (2014)
- Mattson MP, "BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders", Trends Neurosci, 27, pp.589~594 (2004)
- Brindle PK, "The CREB family of transcription activators", Curr Opin Genet Dev, 2, pp.199~204 (1992)
- Nibuya M, "Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus", J Neurosci, 16, pp.2365~2372 (1996)
- Asberg M, "Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies", Ann N Y Acad Sci, 836, pp.158~181 (1997)
- Kasper S, "Panic disorder: the place of benzodiazepines and selective serotonin reuptake inhibitors", Eur Neuropsychopharmacol, 11, pp.307~321 (2001)
- Van Der Kolk BA, "The psychobiology and psychopharmacology of PTSD", Hum Psychopharmacol, 16, pp.S49~S64 (2001)
- Baldwin DS, "Evidence-based pharmacological treatment of generalized anxiety disorder", Int J Neuropsychopharmacol, 14, pp.697~710 (2011)
- Briggs AC, "Subtyping of panic disorder by symptom profile", Br J Psychiatry, 163, pp.201~209 (1993)
- Freire RC, "Panic disorder respiratory subtype:psychopathology, laboratory challenge tests, and response to treatment", Harv Rev Psychiatry, 18, pp.220~229 (2010)
- Pattyn T, "Identifying panic disorder subtypes using factor mixture modelin", Depress Anxiety, 32, pp.509~517 (2015)
- Mann JJ, "Toward a clinical model of suicidal behavior in psychiatric patients", Am J Psychiatry, 156, pp.181~189 (1999)