우울증 환자의 혈액에서 측정되는 BDNF 농도 변화와 그 의미
The Meaning of BDNF Level Measured in Blood of Depressed Patients
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초록
최근 임상 연구들은 우울증 환자에서 BDNF는 감소하고, 우울증의 치료 후에는 BDNF가 증가하여 정상화된다는 결 과를 제시하고 있다. 동물 연구와 임상 연구 모두에서 BDNF의 감소가 직접적으로 우울증을 유발하는지 여부는 명 확하지 않다. 그러나 우울증에서 BDNF 농도의 저하는 우 울증으로 인한 일종의 신경망의 기능부전 상태를 반영한다 고 생각된다. 따라서 향후 더 많은 임상 연구들이 진행되어 BDNF에 대한 지식이 더 쌓이고, 혈중 BDNF 측정 방법이 안정되면, 혈중에서 측정되는 BDNF 농도가 우울증의 심각도, 임상적 특징, 또는 우울증의 치료반응에 대한 생물학적 지표가 될 수 있을 것이다.
Abstract
Brain-derived neurotrophic factor (BDNF) is an important member of the neurotrophic factors, which are critical regulators of the formation and plasticity of neuronal networks. BDNF is abundant in the brain and periphery and it is found in both human serum and plasma. Stressed animals and depressed patients show reduced BDNF expression in the hippocampus and this reduction can be prevented by antidepressant drug treatment. Recent several clinical studies have indicated the decreases of serum or plasma BDNF levels in untreated patients with major depression. These decreases of BDNF can recover after antidepressant treatment. Increasing BDNF after antidepressant treatment could result from improving depressive symptoms, not just from antidepressant treatment. BDNF can play a critical role in the action mechanism of antidepressant treatment. Taken together, major depression may be considered a dysfunction of critical neuronal networks, and the gradual network recovery may induce antidepressant effect. Serum or plasma BDNF levels could indirectly show the above processes of major depression.
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