본문 바로가기
KERD
논문KCI 등재

열충격 단백질의 신경정신의학적 의의와 중요성

Heat shock proteins as molecular chaperons in neuropsychiatry

0

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류정신과학

초록

Abstract

Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins (HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost type of stresses including physical and psychological stresses. Our nervous system in brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. Normal HSPs function is a key factor for endogenous stress adaptation of neural tissues. HSPs play a important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. Altered HSPs function would be associated with the development of several neuropsychiatric disorders. Therefore, understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

참고문헌 (76)

  1. "Ritossa F. A new puffing pattern induced by temperature shock and DNP in Drosophilia. Experientia 1962", pp.571~573
  2. Tissieres A, "Tracy UM. Protein synthesis in salivary glands of Drosophila melanogaster Relation to chromosome puffs. J Mol Biol 1974", pp.389~398
  3. Voellmy R, "Chaperone regulation of the heat shock protein response", 594, pp.89~99 (2007)
  4. Soti C, "Heat shock proteins as emerging therapeutic targets", 146, pp.769~780 (2005)
  5. Smith RC, "Stress proteins in Alzheimer's disease", 21, pp.421~431 (2005)
  6. Macario AJ, "Sick chaperones, cellular stress, and disease", 353, pp.1489~1501 (2005)
  7. Fleshner M, "Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function", 21, pp.457~471 (2005)
  8. Beere HM, ""The stress of dying": the role of heat shock proteins in the regulation of apoptosis", 117, pp.2641~2651 (2004)
  9. Wu C, "Heat shock transcription factors: structure and regulation", 11, pp.441~469 (1995)
  10. Morrison AJ, "Heat shock transcription factors and the hsp70 induction response in brain and kidney of the hyperthermic rat during postnatal development", 75, pp.363~372 (2001)
  11. Goodson ML, "Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities", 15, pp.5288~5293 (1995)
  12. Tonkiss J, "Regulation of heat shock gene transcription in neuronal cells", 21, pp.433~444 (2005)
  13. Guzhova I, "In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance", 914, pp.66~73 (2001)
  14. Bechtold DA, "Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain", 74, pp.641~646 (2000)
  15. Greenberg SG, "Lasek RJ. Heat shock-like protein is transferred from glia to axon. Brain Res 1986", pp.161~164
  16. Tytell M, "Release of heat shock proteins (Hsps) and the effects of extracellular Hsps on neural cells and tissues", 21, pp.445~455 (2005)
  17. Fleshner M, "Diamond DM Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones", 29, pp.1142~1152 (2004)
  18. Johnson JD, "Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72", 99, pp.1789~1795 (2005)
  19. Asea A, "HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine", 6, pp.435~442 (2000)
  20. Pittet JF, "Serum levels of Hsp 72 measured early after trauma correlate with survival", 52, pp.611~617 (2002)
  21. Walsh D, "Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development", 53, pp.198~211 (1997)
  22. Kato M, "Developmental changes of heat shock protein 73 in human brain", 86, pp.180~186 (1995)
  23. Calabrese V, "Molecular chaperones and their roles in neural cell differentiation", 24, pp.1~13 (2002)
  24. Liang P, "Molecular chaperones and the cytoskeleton", 110, pp.1431~1440 (1997)
  25. "Tsang TC. New model for 70 kDa heat-shock proteins' potential mechanisms of function. FEBS Lett 1993", pp.1~3
  26. Meriin AB, "Role of molecular chaperones in neurodegenerative disorders", 21, pp.403~419 (2005)
  27. Gutsmann-Conrad A, "The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects", 241, pp.404~413 (1998)
  28. Jin X, "Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population", 9, pp.69~75 (2004)
  29. Garcia M, "Expanded huntingtin activates the c-Jun terminal kinase", c-Jun pathway prior toaggregate formation in striatal neurons in culture, 2004, pp.127, 859~870
  30. Merienne K, "Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway", 278, pp.16957~16967 (2003)
  31. Blake MJ, "Holbrook NJ. Stress-induced heat shock protein 70 expression in adrenal cortex", pp.9873~9877
  32. Lewthwaite J, "Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stress", 106, pp.196~201 (2002)
  33. Shamaei-Tousi A, "Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus", 27, pp.1565~1570 (2006)
  34. Pratt WB, "Chaperoning of glucocorticoid receptors", 172, pp.111~138 (2006)
  35. Pratt WB, "Role of molecular chaperones in steroid receptor action", 40, pp.41~58 (2004)
  36. "German J. Embryonic stress hypothesis of teratogenesis. Am J Med 1984", pp.293~301
  37. "Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987", pp.660~669
  38. "Finnell RH. Strain differences in expression of the murine heat shock response implications for abnormal neural development. Results Probl Cell Differ 1991", pp.71~82
  39. Bates PR, "Heat stress lipids and schizophrenia", 55, pp.101~107 (1996)
  40. Ganguli R, "Ragu U. Clinical and laboratory evidence of autoimmunity in acute schizophrenia. Ann N Y Acad Sci 1987", pp.676~685
  41. Lewis SW, "and risk of schizophrenia. J Psychiatr Res 1987", pp.413~1421
  42. Mednick SA, "Bonett D. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988"
  43. "Kirch DG. Infection and autoimmunity as etiologic factors in schizophrenia", pp.355~1370
  44. "Kim SU. HSP72 induction by heat stress is not universal in mammalian neural cell lines. J Neurosci Res 1994", pp.44~53
  45. Wang XF, "Studies characterizing 60 kda autoantibodies in subjects with schizophrenia.", 53, pp.361~375 (2003)
  46. Strauss DH, "et al. Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia. Lancet 1992", pp.569~572
  47. Kim JJ, "Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia", 52, pp.127~135 (2001)
  48. Mazeh D, "Antibodies to neuroblastoma cell line proteins in patients with schizophrenia", 84, pp.218~222 (1998)
  49. Schwarz MJ, "Antibodies to heat shock proteins in schizophrenic patients: implications for the mechanism of the disease", 156, pp.1103~1104 (1999)
  50. Pae CU, "Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia", 53, pp.8~13 (2005)
  51. Gabriele JP, "Decreased expression of a 40-kDa catecholamine-regulated protein in the ventral striatum of schizophrenic brain specimens from the Stanley Foundation Neuropathology Consortium", 74, pp.111~119 (2005)
  52. Creagh EM, "Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells", 257, pp.58~66 (2000)
  53. Smith RC, "Stress proteins in Alzheimer's disease", 21, pp.421~431 (2005)
  54. Eric JN, "Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. 1st ed", pp.469~ (2001)
  55. Lukiw WJ, "Gene expression profiling in fetal, aged, and Alzheimer hippocampus: a continuum of stress-related signaling", 29, pp.1287~1297 (2004)
  56. Hamos JE, "Drachman DA. Expression of heat shock proteins in Alzheimer's disease. Neurology 1991", pp.345~350
  57. Magrane J, "heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons", 24, pp.1700~1706 (2004)
  58. Dou F, "Chaperones increase association of tau protein with microtubules", 100, pp.721~726 (2003)
  59. Latchman DS, "HSP27 and cell survival in neurones", 21, pp.393~402 (2005)
  60. Shimura H, "Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival", 279, pp.17957~17962 (2004)
  61. de Kloet ER, "Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?", 3, pp.168~179 (2007)
  62. Yehuda R, "Current status of cortisol findings in post-traumatic stress disorder", 25, pp.341~368 (2002)
  63. Shimizu S, "An allel-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression", 219, pp.745~752 (1996)
  64. Bown C, "Increased temporal cortex ER stress proteins in depressed subjects who died by suicide", 22, pp.327~332 (2000)
  65. Binder EB, "Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment", 36, pp.1319~25 (2004)
  66. Filipovic D, "Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress", 51, pp.107~114 (2005)
  67. Scherrer LC, "Pratt WB. Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex. J Biol Chem 1990", pp.21397~21400, Meshinchi S
  68. Galigniana MD, "Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton", 274, pp.16222~16227 (1999)
  69. Solit DB, "Hsp90: a novel target for cancer therapy", 6, pp.1205~1214 (2006)
  70. Nakahara T, "Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats", 73, pp.193~197 (1999)
  71. Lee JS, "Fluoxetine Pretreatment Exert Time-Dependent Inhabits the Dexamethasone-Meditated Heat Shock Protein 70 Expression in Rat C6 Glioma Cells", 15, pp.66~74 (2004)
  72. Shao L, "Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells", 78, pp.1317~1323 (2006)
  73. Lohff B, "Natural defenses and autoprotection: naturotherapy, an old concept of healing in a new perspective", 51, pp.147~151 (1998)
  74. Lohff B, "Self-healing forces and concepts of health and disease. A historical discourse", 22, pp.543~564 (2001)
  75. Csernansky JG, "Neurodegeneration in schizophrenia: evidence from in vivo neuroimaging studies", 7, pp.135~143 (2007)
  76. Jarskog LF, "Apoptotic proteins in the temporal cortex in schizophrenia: high Bax", Bcl-2 ratio without caspase-3 activation, 2004, pp.161, 109~115

관련 논문AI추천

이 간행물의 다른 논문 (6건)