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Risk of Metabolic and Cardiovascular Risk Factors in Individuals with Autonomic Imbalance Measured by Heart Rate Variability

문지현|김현주|공미희|오윤환|정혜원
대한임상건강증진학회 (Korean Society For Health Promotion And Disease Prevention)|2020.06|Korean Journal of Health Promotion|제20권 제2호|pp. 41-48

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참고문헌

키워드

심박변이도심혈관질환자율신경계Autonomic nervous systemHeart rate variabilityCardiovascular diseaseMetabolic disease대사질환
주제분류기타자연과학

초록

Background: Studies have reported that reduced autonomic nervous system activity could result in a suboptimal health condition and various diseases, further increasing the mortality rate. The present study aimed to determine the difference in risk factors for metabolic and cardiovascular diseases in patients with reduced or unstable autonomic activity according to heart rate variability test results. Methods: We recorded blood pressure, physical measurements (body mass index and waist circumference), fasting blood glucose, and blood lipid status. Indicators representative of autonomic nerve functionality (total power [TP], standard deviation of the normal-to-normal intervals [SDNN], low-frequency band [LF], high-frequency band [HF]) were measured using a 5-minute heart rate variability test. Each indicator was divided into quartiles. Results: In men, the risk of abdominal obesity was high in the group with a low TP. In the group with a low SDNN, TP, and LF, the risk of a blood pressure increase was high. When LH and HF were low, there was a high risk of increased fasting blood sugar, whereas when LH was low, there was a high risk of hypertriglyceridemia. Women with SDNN loss had higher odds ratios for abdominal obesity and low high-density lipoprotein cholesterolemia. Conclusions: These results indicate a higher risk of having risk factors for metabolic and cardiovascular diseases, such as abdominal obesity, elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low high-density lipoprotein cholesterolemia in a group with reduced autonomic activity measured by heart rate variability. Women with a low SDNN had a 4.51-fold higher risk of abdominal obesity than women with a high SDNN, showing the greatest value of the heart rate variability indices.

Abstract

Background: Studies have reported that reduced autonomic nervous system activity could result in a suboptimal health condition and various diseases, further increasing the mortality rate. The present study aimed to determine the difference in risk factors for metabolic and cardiovascular diseases in patients with reduced or unstable autonomic activity according to heart rate variability test results. Methods: We recorded blood pressure, physical measurements (body mass index and waist circumference), fasting blood glucose, and blood lipid status. Indicators representative of autonomic nerve functionality (total power [TP], standard deviation of the normal-to-normal intervals [SDNN], low-frequency band [LF], high-frequency band [HF]) were measured using a 5-minute heart rate variability test. Each indicator was divided into quartiles. Results: In men, the risk of abdominal obesity was high in the group with a low TP. In the group with a low SDNN, TP, and LF, the risk of a blood pressure increase was high. When LH and HF were low, there was a high risk of increased fasting blood sugar, whereas when LH was low, there was a high risk of hypertriglyceridemia. Women with SDNN loss had higher odds ratios for abdominal obesity and low high-density lipoprotein cholesterolemia. Conclusions: These results indicate a higher risk of having risk factors for metabolic and cardiovascular diseases, such as abdominal obesity, elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low high-density lipoprotein cholesterolemia in a group with reduced autonomic activity measured by heart rate variability. Women with a low SDNN had a 4.51-fold higher risk of abdominal obesity than women with a high SDNN, showing the greatest value of the heart rate variability indices.

참고문헌 (32)

  1. "Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology", Circulation, 93(5), pp.1043~1065 (1996)
  2. Singh JP, "Reduced heart rate variability and new-onset hypertension : insights into pathogenesis of hypertension : the Framingham Heart study", Hypertension, 32(2), pp.293~297 (1998)
  3. Schroeder EB, "Diabetes, glucose, insulin, and heart rate variability : the Atherosclerosis Risk in Communities(ARIC)study", Diabetes Care, 28(3), pp.668~674 (2005)
  4. Liao D, "Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes : the atherosclerosis risk in communities(ARIC)study", Diabetes, 51(12), pp.3524~3531 (2002)
  5. Tsuji H, "Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart study", Circulation, 90(2), pp.878~883 (1994)
  6. Gerritsen J, "Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease : the Hoorn study", Diabetes Care, 24(10), pp.1793~1798 (2001)
  7. Thayer JF, "The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors", Int J Cardiol, 141(2), pp.122~131 (2010)
  8. Min KB, "The impact of the components of metabolic syndrome on heart rate variability : using the NCEP-ATP III and IDF definitions", Pacing Clin Electrophysiol, 31(5), pp.584~591 (2008)
  9. Christensen JH, "Heart rate variability and plasma lipids in men with and without ischaemic heart disease", Atherosclerosis, 145(1), pp.181~186 (1999)
  10. Kupari M, "Short-term heart rate variability and factors modifying the risk of coronary artery disease in a population sample", Am J Cardiol, 72(12), pp.897~903 (1993)
  11. Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75(1), pp.72~80 (2007)
  12. Petretta M, "Assessment of cardiac autonomic control by heart period variability in patients with early-onset familial obesity", Eur J Clin Invest, 25(11), pp.826~832 (1995)
  13. Karason K, "Heart rate variability in obesity and the effect of weight loss", Am J Cardiol, 83, pp.1242~1247 (1999)
  14. Liao D, "Association of vagal tone with serum insulin, glucose, and diabetes mellitus--the ARIC study", Diabetes Res Clin Pract, 30(3), pp.211~221 (1995)
  15. Singh JP, "Association of hyperglycemia with reduced heart rate variability(the Framingham Heart study)", Am J Cardiol, 86(3), pp.309~312 (2000)
  16. Liao D, "Association of cardiac autonomic function and the development of hypertension : the ARIC study", Am J Hypertens, 9(12 Pt 1), pp.1147~1156 (1996)
  17. Antelmi I, "Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease", Am J Cardiol, 93(3), pp.381~385 (2004)
  18. Maver J, "Autonomic nervous system and microvascular alterations in normotensives with a family history of hypertension", Blood Press, 13(2), pp.95~100 (2004)
  19. Lindmark S, "Does the autonomic nervous system play a role in the development of insulin resistance? A study on heart rate variability in first-degree relatives of type 2 diabetes patients and control subjects", Diabet Med, 20(5), pp.399~405 (2003)
  20. Lampert R, "Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men", Am Heart J, 156(4), pp.759~ (2008)
  21. Stein PK, "Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals : the Cardiovascular Health study", J Am Geriatr Soc, 56(2), pp.315~321 (2008)
  22. Kolacz J, "Chronic diffuse pain and functional gastrointestinal disorders after traumatic stress : pathophysiology through a polyvagal perspective", Front Med(Lausanne), 5, pp.145~ (2018)
  23. Hayano J, "Short-and long-term effects of cigarette smoking on heart rate variability", Am J Cardiol, 65(1), pp.84~88 (1990)
  24. Fifer WP, "Effects of alcohol and smoking during pregnancy on infant autonomic control", Dev Psychobiol, 51(3), pp.234~242 (2009)
  25. Rennie KL, "Effects of moderate and vigorous physical activity on heart rate variability in a British study of civil servants", Am J Epidemiol, 158(2), pp.135~143 (2003)
  26. Minami J, "Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers", Hypertension, 33(1 Pt 2), pp.586~590 (1999)
  27. Harte CB, "Effects of smoking cessation on heart rate variability among long-term male smokers", Int J Behav Med, 21(2), pp.302~309 (2014)
  28. Yotsukura M, "Heart rate variability during the first month of smoking cessation", Am Heart J, 135(6 Pt 1), pp.1004~1009 (1998)
  29. Sloan RP, "The effect of aerobic training and cardiac autonomic regulation in young adults", Am J Public Health, 99(5), pp.921~928 (2009)
  30. Shaltout HA, "Improvements in heart rate variability, baroreflex sensitivity, and sleep after use of closed-loop allostatic neurotechnology by a heterogeneous cohort", Front Public Health, 6, pp.116~ (2018)
  31. Tegeler CH, "Reduction in menopause-related symptoms associated with use of a noninvasive neurotechnology for autocalibration of neural oscillations", Menopause, 22(6), pp.650~655 (2015)
  32. Tegeler CH, "Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress", BMC Psychiatry, 17(1), pp.141~ (2017)

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