조현병 환자에서 보상 및 손실의 연합 학습의 특징
The Characteristics of Associative Learning of Reward Approach and Loss Aversion in Schizophrenia
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Objectives : Schizophrenia patients have deficits of prediction and learning related to dopaminergic dysfunction. It is hypothesized that there would be different characteristics in associative learning of reward approach and loss aversion between controls and patients. Methods : Participants were 23 healthy participants and 20 out-patients fulfilling criteria for schizophrenia according DSM-IV-TR. Using a monetary incentive contingency reversal task, successful learning rates, numbers of trials and errors till learning, numbers of trials of maintaining learning, response times were measured. Characteristics of learning were compared between controls and patients. Results : Physical anhedonia and PANSS negative symptom scores correlated with the number of trials while loss aversion was maintained. Overall correct response rates were decreased in patient group, particularly during reward approach learning. Patients required more trials and errors to learn reward approach than controls. There were no significant differences in learning performance and reaction times between groups during loss avoidance learning. Conclusion : These results support previous reports of deficits in reward-driven learning in schizophrenia. However, anhedonia and negative symptoms were associated with the preserved function of loss avoidance learning.
Abstract
Objectives : Schizophrenia patients have deficits of prediction and learning related to dopaminergic dysfunction. It is hypothesized that there would be different characteristics in associative learning of reward approach and loss aversion between controls and patients. Methods : Participants were 23 healthy participants and 20 out-patients fulfilling criteria for schizophrenia according DSM-IV-TR. Using a monetary incentive contingency reversal task, successful learning rates, numbers of trials and errors till learning, numbers of trials of maintaining learning, response times were measured. Characteristics of learning were compared between controls and patients. Results : Physical anhedonia and PANSS negative symptom scores correlated with the number of trials while loss aversion was maintained. Overall correct response rates were decreased in patient group, particularly during reward approach learning. Patients required more trials and errors to learn reward approach than controls. There were no significant differences in learning performance and reaction times between groups during loss avoidance learning. Conclusion : These results support previous reports of deficits in reward-driven learning in schizophrenia. However, anhedonia and negative symptoms were associated with the preserved function of loss avoidance learning.
참고문헌 (23)
- Strauss GP, "Deficits in positive reinforcement learning and uncertaintydriven exploration are associated with distinct aspects of negative symptoms in schizophrenia", Biological Psychiatry, 69, pp.424~431 (2011)
- Berridge KC, "Parsing reward", TRENDS in Neurosciences, 26, pp.507~513 (2003)
- Waltz JA, "Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction", Biological Psychiatry, 62, pp.756~764 (2007)
- Prentice KJ, "The Wisconsin Card Sorting impairment in schizophrenia is evident in the first four trials", Schizophrenia Research, 106, pp.81~87 (2008)
- Kapur S., "Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia", American Journal of Psychiatry, 160, pp.13~23 (2003)
- Frank MJ., "Schizophrenia: a computational reinforcement learning perspective", Schizophrenia Bulletin, 34, pp.1008~1011 (2008)
- Gard DE, "Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure", Schizophrenia Research, 93, pp.253~260 (2007)
- Gold JM, "Reward processing in schizophrenia: a deficit in the representation of value", Schizophrenia Bulletin, 34, pp.835~847 (2008)
- Wächter T, "Differential effect of reward and punishment on procedural learning", The Journal of Neuroscience, 29, pp.436~443 (2009)
- Association AP., "Diagnostic and statistical manual of mental disorders: DSM-IV-TR. ed" (2000), American Psychiatric Publishing
- Raven J., "Raven-Matrizen-test standard progressive matrices" (1988), Test Gesellschaft
- Chapman LJ, "Scales for physical and social anhedonia", Journal of Abnormal Psychology, 85, pp.374~ (1976)
- Watson D, "Development and validation of brief measures of positive and negative affect: the PANAS scales", Journal of Personality and Social Psychology, 54, pp.1063~ (1988)
- 민병배, "기질 및 성격검사 매뉴얼" (2007), (주)마음사랑
- 이중서, "한국판 양성 및 음성증후군 척도(Positive and Negative Syndrome Scale)의 신뢰도와 타당도", 신경정신의학, 40(6), pp.1090~1105 (2001), 대한신경정신의학회
- van der Gaag M, "The five-factor model of the Positive and Negative Syndrome Scale II: a ten-fold cross-validation of a revised model", Schizophrenia Research, 85, pp.280~287 (2006)
- Blanchard JJ, "Anhedonia, positive and negative affect, and social functioning in schizophrenia", Schizophrenia Bulletin, 24, pp.413~424 (1998)
- Waltz JA, "Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction", Schizophrenia Research, 93, pp.296~303 (2007)
- 김양태, "Dissociation of emotional decision-making from cognitive decision-making in chronic schizophrenia", PSYCHIATRY RESEARCH, 152, pp.113~120, ELSEVIER IRELAND LTD
- Danion JM, "Defective relationship between subjective experience and behavior in schizophrenia", American Journal of Psychiatry, 158, pp.2064~2066 (2001)
- Wise RA, "Dopamine, learning and motivation", Nature Reviews Neuroscience, 5, pp.483~494 (2004)
- Arnt J., "Pharmacological specificity of conditioned avoidance response inhibition in rats: inhibition by neuroleptics and correlation to dopamine receptor blockade", Acta Pharmacologica et Toxicologica, 51, pp.321~329 (1982)
- Borison R., "The role of cognition in the risk-benefit and safety analysis of antipsychotic medication", Acta Psychiatrica Scandinavica, 94, pp.5~11 (1996)