신경 발달 장애에서 정신병 혹은 양극성 장애로의 전환 확률
Probability of Transition to Psychosis and Bipolar Disorder in Individuals With Neurodevelopmental Disorders
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Objectives: The clinical trajectories of adolescent-onset psychosis and bipolar disorder are worse than that of adult-onset cases. Although psychosis and bipolar disorder are more prevalent among those with neurodevelopmental disorders such as ADHD and autism spectrum disorder compared with the general population, the incidence during adolescence has not yet been explored. Methods: Out of 3,730 patients who visited the Department of Pediatric Psychiatry at Pusan National University Yangsan Hos- pital between November 2008 and May 2021, patients with neurodevelopmental disorders who did not meet the criteria for psy- chosis or bipolar disorder and had at least one year of the follow-up period were selected. A Kaplan-Meier analysis was performed to examine the cumulative incidence of psychosis and bipolar disorder in patients with neurodevelopmental disorders. Results: The sample included 591 patients with neurodevelopmental disorders (mean age 12.6 years, range 10-18 years). The 9-years cumulative incidences of psychosis and bipolar disorder are 1.3% (95% CI=0.2%-2.4%), 11.6% (95% CI=7.4%-15.6%), respectively. Conclusion: Patients with neurodevelopmental disorders showed a high incidence of psychosis and bipolar disorder during ado- lescence. This suggests that patients diagnosed with neurodevelopmental disorders should be continuously evaluated and moni- tored of the occurrence of comorbidities during adolescence.
Abstract
Objectives: The clinical trajectories of adolescent-onset psychosis and bipolar disorder are worse than that of adult-onset cases. Although psychosis and bipolar disorder are more prevalent among those with neurodevelopmental disorders such as ADHD and autism spectrum disorder compared with the general population, the incidence during adolescence has not yet been explored. Methods: Out of 3,730 patients who visited the Department of Pediatric Psychiatry at Pusan National University Yangsan Hos- pital between November 2008 and May 2021, patients with neurodevelopmental disorders who did not meet the criteria for psy- chosis or bipolar disorder and had at least one year of the follow-up period were selected. A Kaplan-Meier analysis was performed to examine the cumulative incidence of psychosis and bipolar disorder in patients with neurodevelopmental disorders. Results: The sample included 591 patients with neurodevelopmental disorders (mean age 12.6 years, range 10-18 years). The 9-years cumulative incidences of psychosis and bipolar disorder are 1.3% (95% CI=0.2%-2.4%), 11.6% (95% CI=7.4%-15.6%), respectively. Conclusion: Patients with neurodevelopmental disorders showed a high incidence of psychosis and bipolar disorder during ado- lescence. This suggests that patients diagnosed with neurodevelopmental disorders should be continuously evaluated and moni- tored of the occurrence of comorbidities during adolescence.
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