Differences in Psychopathology between Offspring of Parents with Bipolar I Disorder and Those with Bipolar II Disorder: A Cross-Sectional Study
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II). Methods The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years. Results In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II. Conclusion The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.
Abstract
Objective The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II). Methods The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years. Results In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II. Conclusion The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.
참고문헌 (54)
- Judd LL, "The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases", J Affect Disord, 73, pp.123~131 (2003)
- Pradhan S, "Psycho-social dysfunctions in patients after recovery from mania and depression", Int J Rehab Res, 22, pp.303~309 (1999)
- Judd LL, "Psychosocial disability in the course of bipolar I and II disorders:a prospective, comparative, longitudinal study", Arch Gen Psychiatry, 62, pp.1322~1330 (2005)
- Xu G, "Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: a longitudinal, naturalistic study", J Affect Disord, 136, pp.328~339 (2012)
- Dell’Osso B, "American tertiary clinic-referred bipolar II disorder compared to bipolar I disorder: more severe in multiple ways, but less severe in a few other ways", J Affect Disord, 188, pp.257~262 (2015)
- Fletcher K, "Temperament and personality in bipolar II disorder", J Affect Disord, 136, pp.304~309 (2012)
- Parker G, "Differentiating bipolar I and II disorders and the likely contribution of DSM-5 classification to their cleavage", J Affect Disord, pp.152~154 (2014)
- Heun R, "The distinction of bipolar II disorder from bipolar I and recurrent unipolar depression: results of a controlled family study", Acta Psychiatr Scand, 87, pp.279~284 (1993)
- Andreasen NC, "Familial rates of affective disorder", Arch Gen Psychiatry, 44, pp.461~469 (1987)
- Song J, "Specificity in etiology of subtypes of bipolar disorder: Evidence from a Swedish population-based family study", Biol Psychiatry (2017)
- Charney A, "Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder", Transl Psychiatry, 7, pp.e993~ (2017)
- Baek JH, "Differences between bipolar I and bipolar II disorders in clinical features, comorbidity, and family history", J Affect Disord, 131, pp.59~67 (2011)
- Lapalme M, "Children of parents with bipolar disorder: a metaanalysis of risk for mental disorders", Can J Psychiatry, 42, pp.623~631 (1997)
- Diler RS, "Dimensional psychopathology in offspring of parents with bipolar disorder", Bipolar Disord, 13, pp.670~678 (2011)
- Faraone SV, "The genetics of pediatric-onset bipolar disorder", Biol Psychiatry, 53, pp.970~977 (2003)
- Pavuluri MN, "Pediatric bipolar disorder: a review of the past 10 years", J Am Acad Child Adolesc Psychiatry, 44, pp.846~871 (2005)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders (DSM-5®)" (2013), American Psychiatric Association
- Kaufman J, "Schedule for affective disorders and schizophrenia for school-age childrenpresent and lifetime version (K-SADS-PL): initial reliability and validity data", J Am Acad Child Adolesc Psychiatry, 36, pp.980~988 (1997)
- 김영신, "The Reliability and Validity of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version (K-SADS-PL-K)", Yonsei Medical Journal, 45(1), pp.81~89 (2004), 연세대학교의과대학
- Mesman E, "The Dutch bipolar offspring study: 12-year follow-up", Am J Psychiatry, 170, pp.542~549 (2013)
- Wagner KD, "Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents", J Clin Psychiatry, 67, pp.827~830 (2006)
- Se-Hoon Shim, "Screening with the Korean Version of the Mood Disorder Questionnaire for Bipolar Disorders in Adolescents: Korean Validity and Reliability Study", Clinical Psychopharmacology and Neuroscience, 16(3), pp.316~323 (2018), 대한정신약물학회[DOI]
- Youngstrom EA, "Developing a 10-item mania scale from the Parent General Behavior Inventory for children and adolescents", J Clin Psychiatry, 69, pp.831~839 (2008)
- Lee HJ, "Diagnostic validity and reliability of a Korean version of the Parent and Adolescent General Behavior Inventories", Compr Psychiatry, 55, pp.1730~1737 (2014)
- DuPaul GJ., "Parent and teacher ratings of ADHD symptoms: psychometric properties in a community-based sample", J Clin Child Adolesc Psychol, 20, pp.245~253 (1991)
- 소유경, "한국어판 부모, 교사 ADHD 평가 척도의 신뢰도와 타당도 연구", 신경정신의학, 41(2), pp.283~289 (2002), 대한신경정신의학회
- Reynolds CR, "Revised Children’s Manifest Anxiety Scale" (1985), Western Psychological Services
- Cho SC, "Development of the Korean form of the state-trait anxiety inventory for children", Seoul J Psychiatry, 14, pp.150~157 (1989)
- Kovacs M., "The Children’s Depression Inventory: A Self-Rated Depression Scale for School-Aged Youngsters" (1983), University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic
- Cho SC, "Development of the Korean form of the Kovacs’ Children’s Depression Inventory", J Korean Neuropsychiatr Assoc, 29, pp.943~956 (1990)
- Childhood Trauma Questionnaire: A Retrospective Self-Report: Manual, "Bernstein DP", Psychological Corporation, ~ (1998)
- 유재학, "한국판 아동기 외상 질문지의 타당화: 상담 및 치료적 개입에서의 활용", 한국심리학회지: 건강, 14(3), pp.563~578 (2009), 한국건강심리학회[DOI]
- Zappitelli MC, "Lifetime psychopathology among the offspring of Bipolar I parents", Clinics, 66, pp.725~730 (2011)
- Duffy A, "The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents", Bipolar Disord, 9, pp.828~838 (2007)
- Dervic K, "Bipolar I and II versus unipolar depression: clinical differences and impulsivity", aggression traits, 2015, pp.30, 106~113
- Molnar BE, "Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey", Am J Pub Health, 91, pp.753~760 (2001)
- Chang K, "Bipolar offspring:a window into bipolar disorder evolution", Biol Psychiatry, 53, pp.945~951 (2003)
- Chang KD, "Family environment of children and adolescents with bipolar parents", Bipolar Disord, 3, pp.73~78 (2001)
- Sidebotham P, "Child maltreatment in the “Children of the Nineties”: A longitudinal study of parental risk factors", Child Abuse Negl, 25, pp.1177~1200 (2001)
- Egeland JA, "A 16-year prospective study of prodromal features prior to BPI onset in well Amish children", J Affect Disord, 142, pp.186~192 (2012)
- Henin A, "Psychopathology in the offspring of parents with bipolar disorder:a controlled study", Biol Psychiatry, 58, pp.554~561 (2005)
- Hammen C, "Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder", Arch Gen Psychiatry, 47, pp.1112~1117 (1990)
- Duffy A, "A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment", J Clin Psychiatry, 63, pp.1171~1178 (2002)
- Chang KD, "Psychiatric phenomenology of child and adolescent bipolar offspring", J Am Acad Child Adolesc Psychiatry, 39, pp.453~460 (2000)
- Aldinger F, "Environmental factors, life events, and trauma in the course of bipolar disorder", Psychiatry Clin Neurosci, 71, pp.6~17 (2017)
- Merikangas K, "Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders", Mol Psychiatry, 19, pp.214~219 (2014)
- Ha TH, "Regional brain gray matter abnormalities in patients with bipolar II disorder: A comparison study with bipolar I patients and healthy controls", Neurosci Lett, 456, pp.44~48 (2009)
- Carlson GA, "Childhood behavior problems and bipolar disorder-relationship or coincidence?", J Affect Disord, 28, pp.143~153 (1993)
- Geller B, "Diagnostic characteristics of 93 cases of a prepubertal and early adolescent bipolar disorder phenotype by gender, puberty and comorbid attention deficit hyperactivity disorder", J Child Adolesc Psychopharmacol, 10, pp.157~164 (2000)
- Chang K, "Studies of offspring of parents with bipolar disorder", Am J Med Genet C Semin Med Genet, 15(123C), pp.26~35 (2003)
- Nierenberg AA, "Clinical and diagnostic implications of lifetime attentiondeficit", hyperactivity disorder comorbidity in adults with bipolar disorder:data from the first 1000 STEP-BD participants, 2005, pp.57, 1467~1473
- Biederman J, "Attention-deficit hyperactivity disorder and juvenile mania: an overlooked comorbidity?", J Am Acad Child Adolesc Psychiatry, 35, pp.997~1008 (1996)
- Milberger S, "Attention deficit hyperactivity disorder and comorbid disorder: Issues of overlapping symptoms", Am J Psychiatry, 152, pp.1793~1799 (1995)
- Abbo C, "Prevalence, comorbidity and predictors of anxiety disorders in children and adolescents in rural north-eastern Uganda", Child Adolesc Psychiatry Ment Health, 7, pp.21~ (2013)
