한우에서의 Myostatin 유전변이와 도체형질간 연관성 분석
Association Analysis of Carcass Traits and Genetic Variation of Myostatin Gene in Hanwoo
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Thus far, there have been many studies focusing on meat quality improvement for Hanwoo (Korean cattle). It is considered that studies on meat quality have been actively conducted because beef consumption has changed from quantity to quality since early 1990's. Moreover, many studies on meat quality using maker assisted selection (MAS) have been conducted. However, there is a need to study quantity of meat in order to enhance the economic effect by genetic diversity and quantity of meat for Hanwoo. Therefore, in order to use a myostatin gene affecting meat quantity among quantitative genes for MAS, this study analyzed the association between genetic variation of myostatin gene in individuals of Hanwoo and carcass traits. Analysis between genotypes and individual phenotypic characteristics was performed by ANOVA using ASREML. Association analysis between these 10 SNPs and phenotypic characteristics (carcass weight, eye muscle area, backfat thickness, marbling score, yield index), and there were significant differences in 5 SNPs. As a result, there were five significant differences. Although all the SNPs did not show significant differences in each trait in this study, some SNPs showed significant differences in each trait. The diversity of myostatin gene was found in Hanwoo.
Abstract
Thus far, there have been many studies focusing on meat quality improvement for Hanwoo (Korean cattle). It is considered that studies on meat quality have been actively conducted because beef consumption has changed from quantity to quality since early 1990's. Moreover, many studies on meat quality using maker assisted selection (MAS) have been conducted. However, there is a need to study quantity of meat in order to enhance the economic effect by genetic diversity and quantity of meat for Hanwoo. Therefore, in order to use a myostatin gene affecting meat quantity among quantitative genes for MAS, this study analyzed the association between genetic variation of myostatin gene in individuals of Hanwoo and carcass traits. Analysis between genotypes and individual phenotypic characteristics was performed by ANOVA using ASREML. Association analysis between these 10 SNPs and phenotypic characteristics (carcass weight, eye muscle area, backfat thickness, marbling score, yield index), and there were significant differences in 5 SNPs. As a result, there were five significant differences. Although all the SNPs did not show significant differences in each trait in this study, some SNPs showed significant differences in each trait. The diversity of myostatin gene was found in Hanwoo.
참고문헌 (17)
- Arthur, P. F., "Incidence of dystocia and perinatal calf mortality resulting from reciprocal crossing of double-muscled and normal cattle", CVMA, 29, pp.163~167 (1988)
- Arthur, P. F., "Heterosis, maternal and direct effects in double-muscled and normal cattle: I. Reproduction and growth traits", J. Anim. Sci, 87, pp.902~910 (1989)
- Arthur, P. F., "Plasma growth hormone and insulin concentrations in doublemuscled and normal bull calves", J. Anim. Sci, 68, pp.1609~1615 (1990)
- Boman, I. A., "A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis Aries)", Anim. Genet, 40, pp.418~422 (2009)
- Casas, E., "Association of the muscle hypertrophy locus with carcass traits in beef cattle", J. Anim. Sci, 76, pp.468~473 (1998)
- Dunner, S., "Haplotype diversity of the myostatin gene among beef cattle breeds", Genet. Sel. Evol, 35, pp.103~ (2003)
- Fahrenkrug, S. C., "Technical note: direct genotyping of the double-muscling locus (mh) in Piedmontese and Belgian Blue cattle by fluorescent PCR", J. Anim. Sci, 77, pp.2028~2030 (1999)
- Georges, M., "Positional candidate cloning of the bovine mh locus identifies an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle", Proceedings of the 6th World Congress on Genetics Applied to Livestock Production, 26, pp.195~204 (1998)
- Grobet, L., "Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle", Mamm. Genome, 9, pp.210~213 (1998)
- Holmes, J. H., "Effects of stress on cattle with hereditary muscular hypertrophy", J. Anim. Sci, 36, pp.684~694 (1973)
- Boman, I. A, "Impact of two myostatin (MSTN) mutations on weight gain and lamb carcass classification in Norwegian White Sheep (Ovis aries)", Genet. Sel. Evol, 42, pp.4~ (2010)
- Johansen, J., "Validation of the EUROP system for lamb classification in Norway; repeatability and accuracy of visual assessment and prediction of lamb carcass composition", Meat Sci, 74, pp.497~509 (2006)
- Karim, L., "Convenient genotyping of six myostatin mutations causing double-muscling in cattle using a multiplex oligonucleotide ligation assay", Anim. Genet, 31, pp.396~399 (2000)
- McPherron, A. C., "Double muscling in cattle due to mutations in the myostatin gene", Proc. Natl. Acad. Sci. U. S. A, 94, pp.12457~12461 (1997)
- McPherron, A. C., "Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member", Nature, 387, pp.83~90 (1997)
- Lee, S. H., "Genome wide association test to identity QTL for dressing precentage in Hanwoo", J. Agri. Sci. CNU, 40(2), pp.155~162 (2013)
- Yu, S. L, "SNP and Expression Analyses of Myostatin Gene in korean Cattle(Hanwoo)", J. Agri. Sci. C. N. U, 31(2), pp.97~104 (2004)