후각질환에서 부데소나이드 비강세척 또는 비강 내 스테로이드 스프레이의 효과
The Effect of Nasal Budesonide Irrigation or Intranasal Steroid on Olfactory Disorders
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Background and Objectives: Oral steroid medication is known to be effective in the treatment of olfactory dysfunc- tion, but long-term steroid use can lead to serious complications such as high blood pressure, diabetes, and gastric ulcers. In this study, the authors aimed to investigate the effects of oral steroid medication with nasal spray and budesonide nasal irrigation alone or nasal spray alone on olfactory disorders. Materials and Methods: A total of 222 patients of anosmia or hyposmia had been treated in Department of Otorhinolaryngology of Haeundae Paik Hospi- tal from March 2010 to December 2022 and were reviewed retrospectively. First, they underwent a 2-week course of oral steroid medication with nasal spray, followed by a pre- and post-treatment with the Korean version of the Sniffin' Sticks (KVSS)-II olfactory assessment. 41 patients finished the first treatment and were divided into two groups. Group 1 (25 patients) used nasal spray alone once a day, while Group 2 (19 patients) underwent budesonide nasal irrigation twice a day. Results: The KVSS-II scores for 41 patients who received the first treatment showed statistically significant improvement (12.6±6.4 to 17.1±5.4, p=0.000). The Group 1 experienced a statistically non-significant decrease in the KVSS-II scores (17.8±5.6 to 15.4±6.5, p=0.140). The KVSS-II scores in Group 2 showed improvement but there was no statistical significance (14.4±4.5 to 16.3±5.4, p=0.326). Conclusion: Using nasal spray alongside oral steroid medication demonstrated statistically significant effects on olfactory disorders. However, using nasal spray alone or budesonide nasal irrigation alone did not show statistically significant results.
Abstract
Background and Objectives: Oral steroid medication is known to be effective in the treatment of olfactory dysfunc- tion, but long-term steroid use can lead to serious complications such as high blood pressure, diabetes, and gastric ulcers. In this study, the authors aimed to investigate the effects of oral steroid medication with nasal spray and budesonide nasal irrigation alone or nasal spray alone on olfactory disorders. Materials and Methods: A total of 222 patients of anosmia or hyposmia had been treated in Department of Otorhinolaryngology of Haeundae Paik Hospi- tal from March 2010 to December 2022 and were reviewed retrospectively. First, they underwent a 2-week course of oral steroid medication with nasal spray, followed by a pre- and post-treatment with the Korean version of the Sniffin' Sticks (KVSS)-II olfactory assessment. 41 patients finished the first treatment and were divided into two groups. Group 1 (25 patients) used nasal spray alone once a day, while Group 2 (19 patients) underwent budesonide nasal irrigation twice a day. Results: The KVSS-II scores for 41 patients who received the first treatment showed statistically significant improvement (12.6±6.4 to 17.1±5.4, p=0.000). The Group 1 experienced a statistically non-significant decrease in the KVSS-II scores (17.8±5.6 to 15.4±6.5, p=0.140). The KVSS-II scores in Group 2 showed improvement but there was no statistical significance (14.4±4.5 to 16.3±5.4, p=0.326). Conclusion: Using nasal spray alongside oral steroid medication demonstrated statistically significant effects on olfactory disorders. However, using nasal spray alone or budesonide nasal irrigation alone did not show statistically significant results.
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