후각장애 환자에서의 스테로이드 효과 분석
Analysis of Steroid Effect in Patients with Olfactory Dysfunction
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Background and Objectives Olfaction plays an important role on sensing and discriminatingsmell and taste. The number of patients visiting outpatient department for treatment of olfactorydysfunction is increasing along with the change in patients’ perception about the importanceof olfactory function. Subjects and Method Patients with olfactory dysfunction, who visited the hospital from2010 to 2018, were included in this study. The medical records were reviewed focusing on theKorean Version of Sniffin’ Stick, the CT finding of olfactory cleft or signs of sinusitis, and theeffect of oral steroids. Postviral olfactory disorder (PVOD) patients and chronic rhinosinusitis(CRS) patients were treated by oral steroid, starting on prednisolon (Solondo Tab®, YuHanCorp.; 40 mg per day) and tapered for 2 weeks. Results There were 13 cases where patients’ sense of smell was improved only for a shortperiod of time after taking steroids but worsened thereafter. They showed improvement of olfactoryfunction every time they took steroids. We defined this group as “steroid dependentolfactory dysfunction.”Conclusion It is necessary to understand the physiology and molecular biologic mechanismsbehind the causes of olfactory dysfunction in order to establish the diagnostic criteria andtreatment strategy. Steroid dependent olfactory dysfunction also needs more investigation.
Abstract
Background and Objectives Olfaction plays an important role on sensing and discriminatingsmell and taste. The number of patients visiting outpatient department for treatment of olfactorydysfunction is increasing along with the change in patients’ perception about the importanceof olfactory function. Subjects and Method Patients with olfactory dysfunction, who visited the hospital from2010 to 2018, were included in this study. The medical records were reviewed focusing on theKorean Version of Sniffin’ Stick, the CT finding of olfactory cleft or signs of sinusitis, and theeffect of oral steroids. Postviral olfactory disorder (PVOD) patients and chronic rhinosinusitis(CRS) patients were treated by oral steroid, starting on prednisolon (Solondo Tab®, YuHanCorp.; 40 mg per day) and tapered for 2 weeks. Results There were 13 cases where patients’ sense of smell was improved only for a shortperiod of time after taking steroids but worsened thereafter. They showed improvement of olfactoryfunction every time they took steroids. We defined this group as “steroid dependentolfactory dysfunction.”Conclusion It is necessary to understand the physiology and molecular biologic mechanismsbehind the causes of olfactory dysfunction in order to establish the diagnostic criteria andtreatment strategy. Steroid dependent olfactory dysfunction also needs more investigation.
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