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Fist generic advantage in generic competition - selection bias problem

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The aim of this paper is to estimate the advantage of first generic drugs in pharmaceutical industry taking into account the selection bias problem in unobservable variables. I use the non-parametric method to identify the parameter of interest and it is shown that heterogeneity among firms is not a substantial problem with our data. Three alternative approaches are studied to evaluate the first mover advantage: linear regression, matching methods, and instrumental variables (IV). Under the necessary assumptions and the data requirements for each method, linear regression estimate 26.3% increased in market share for the first generics (matching method is 26.2%, IV is 32.58%). If we compare it to the second generic, the first mover advantage amounts to 21.5%.

Abstract

The aim of this paper is to estimate the advantage of first generic drugs in pharmaceutical industry taking into account the selection bias problem in unobservable variables. I use the non-parametric method to identify the parameter of interest and it is shown that heterogeneity among firms is not a substantial problem with our data. Three alternative approaches are studied to evaluate the first mover advantage: linear regression, matching methods, and instrumental variables (IV). Under the necessary assumptions and the data requirements for each method, linear regression estimate 26.3% increased in market share for the first generics (matching method is 26.2%, IV is 32.58%). If we compare it to the second generic, the first mover advantage amounts to 21.5%.

참고문헌 (12)

  1. Becker, S., "Estimation of average treatment effects based on propensity scores", Stata Journal, 2(4), pp.358~377 (2002)
  2. Cleveland, W.S., "Robust Locally Weighted Regression and Smoothing Scatterplots", Journal of the American Statistical Association, 74, pp.829~836 (1979)
  3. Henry G. Grabowski, "Brand Loyalty, Entry, and Price competition in pharmaceuticals after the 1984 Drug act", Journal of Law and Economics, pp.331~350 (1992)
  4. J. Heckman, "Sample selection bias as a specification error", pp.153~161 (1979), Econometrica
  5. J. Heckman, "Local Instrumental Variable and Latent Variable Models for Identifying and Bounding Treatment Effects", Proceedings of the National Academy of Sciences, 96, pp.4730~4734 (1999)
  6. J. Heckman, "Local Instrumental Variables, In Nonlinear Statistical Modeling: Proceedings of the Thirteenth International Symposium in Economic Theory and Econometrics: Essays in Honor of Takeshi Amemiya", pp.1~46 (2000), Cambridge University Press
  7. Aidan Hollis, "The importance of being first: Evidence from canadian generic pharmaceuticals", Health Economics, pp.723~734 (2002)
  8. Rosenbaum P., "The central role of the propensity score in observational studies for casual effects", Biometrika, pp.41~55 (1983)
  9. P. Robinson, "Root-n-consistent semi-parametric regression", pp.931~954 (1988), Econometrica
  10. M.B Lieberman, "First-Mover Advantage", Strategic Management Journal, 9(Special), pp.41~58 (1988)
  11. KHIDI, "2008 Korea pharmaceutical industy directory"
  12. Pharmaceutical sector inquiry preliminary Report, "European Commission Competition DG", ~ (2008)

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