농촌지역 주민의 공복혈당장애와 관련요인
Associated Factors of Impaired Fasting Glucose in Some Korean Rural Adults
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Objectives: This study was performed to investigate the prevalence of impaired fasting glucose (IFG) and its related characteristics among healthy adults in some Korean rural areas. Methods: We conducted a cross-sectional study using the data from 1352 adults who were over the age 40 and under the age 70 and who were free of diabetes mellitus (DM), cardiovascular diseases and other diseases and who participated in a survey conducted as part of the Korean Rural Genomic Cohort Study. IFG was defined as a serum fasting glucose level between 100and 125 mg/dL. Results: The prevalence of IFG was 20.4% in men, 15.5% in women and 12.7% overall. Multivariate logistic regression analysis demonstrated that the independent risk factors for IFG were male gender, having a family history of DM, the quartiles of gamma glutamyltransferase and high sensitive C-reactive protein and the waist circumference. The homeostatis model assessment for insulin resistance was very strongly associated with IFG. The prevalence of metabolic syndrome (MS) and MS components was higher in the subjects with IFG then in those with normal fasting glucose (NFG). Conclusions: The result of study could supply evidence to find the high risk population and to determine a strategy for treating IFG. Further research is needed to explain the causal relationship and mechanisms of IFG.
Abstract
Objectives: This study was performed to investigate the prevalence of impaired fasting glucose (IFG) and its related characteristics among healthy adults in some Korean rural areas. Methods: We conducted a cross-sectional study using the data from 1352 adults who were over the age 40 and under the age 70 and who were free of diabetes mellitus (DM), cardiovascular diseases and other diseases and who participated in a survey conducted as part of the Korean Rural Genomic Cohort Study. IFG was defined as a serum fasting glucose level between 100and 125 mg/dL. Results: The prevalence of IFG was 20.4% in men, 15.5% in women and 12.7% overall. Multivariate logistic regression analysis demonstrated that the independent risk factors for IFG were male gender, having a family history of DM, the quartiles of gamma glutamyltransferase and high sensitive C-reactive protein and the waist circumference. The homeostatis model assessment for insulin resistance was very strongly associated with IFG. The prevalence of metabolic syndrome (MS) and MS components was higher in the subjects with IFG then in those with normal fasting glucose (NFG). Conclusions: The result of study could supply evidence to find the high risk population and to determine a strategy for treating IFG. Further research is needed to explain the causal relationship and mechanisms of IFG.
참고문헌 (39)
- Wild S, "Global prevalence of diabetes: estimates for the year 2000 and projections for 2030", Diabetes Care, 27(5), pp.1047~1053 (2004)
- Kim JS, "Mean fasting blood glucose level and an estimated prevalence of diabetes mellitus among a representative adult Korean population", Korean J Prev Med, 26(3), pp.311~320 (1993)
- Ministry of Health & Welfare; Korea Centers for Disease Control and Prevention, "Disease Control and Prevention. 2007 National Health Statistics: The fourth Korean National Health and Nutrition Examination Survey, 1st Year Results" (2007), Korea Centers for Disease Control and Prevention
- Unwin N, "Impaired glucose tolerance and impaired fasting glycemia: the current status on definition and intervention", Diabet Med, 19(9), pp.708~723 (2002)
- Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus", Diabetes Care, 20(7), pp.1183~1197 (1997)
- Del Prato S, "Phasic insulin release and metabolic regulation in type 2 diabetes", Diabetes, 51(1), pp.S109~S116 (2002)
- Lim SC, "Cardiovascular risk profile in individuals with borderline glycemia: the effect of the 1997 American Diabetes Association diagnostic criteria and the 1998 World Health Organization Provisional Report", Diabetes Care, 23(3), pp.278~282 (2000)
- DECODE Study Group, the European Diabetes Epidemiology Group, "Glucose tolearnce and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria", Arch Intern Med, 161(3), pp.397~405 (2001)
- American Diabetes Association, "Diagnosis and classification of diabetes mellitus", Diabetes Care, 27(1), pp.S5~S10 (2004)
- Bjornholt JV, "Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men", Diabetes Care, 22(1), pp.45~49 (1999)
- Tuomilehto J, "Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance", N Engl J Med, 344(18), pp.1343~1350 (2001)
- Jiamjarasrangsi W, "Increased alanine aminotransferase level and future risk of type 2 diabetes and impaired fasting glucose among the employees in a university hospital in Thailand", Diabetes Metab, 34(3), pp.283~289 (2008)
- Nakanishi N, "Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men", J Intern Med, 254(3), pp.287~295 (2003)
- Sakai Y, "Relation of alcohol use and smoking to glucose tolerance status in Japanese men", Diabetes Res Clin Pract, 73(1), pp.83~88 (2006)
- Rafalson L, "Cigarette smoking is associated with conversion from normoglycemia to impaired fasting glucose: the Western New York Health Study", Ann Epidemiol, 19(6), pp.365~371 (2009)
- Kriska AM, "The association of physical activity with obesity, fat distribution and glucose intolearnce in Pima Indians", Diabetologia, 36(9), pp.863~869 (1993)
- 김진화, "나주지역 중년인구에서 공복혈당을 통한 당뇨병 진단의 적절성 평가", Diabetes and Metabolism Journal, 32(4), pp.328~337 (2008), 대한당뇨병학회
- Ryu S, "Should the lower limit of impaired fasting glucose be reduced from 110 mg", dL in Korea?, 2006, pp.55(4), 489~493
- 류승호, "복부비만이 제2형 당뇨병 및 공복혈당장애 발생에 미치는 영향: 후향적 코호트 연구", 예방의학회지, 37(4), pp.359~365 (2004), 대한예방의학회
- Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75(1), pp.72~80 (2007)
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentration in man", Diabetologia, 28(7), pp.412~419 (1985)
- Korea Centers for Disease Control and Prevention, "Indepth Study Report of the Third Korean National Health and Nutrition Examination Survey: Health Examination Parts" (2007), Korea Centers for Disease Control and Prevention
- Song KH, "Change in prevalence and 6-year incidence of diabetes and impaired fasting glucose in Korean subjects living in a rural area", Diabetes Res Clin Pract, 78(3), pp.378~384 (2007)
- 김철식, "신체 계측 특성 및 식사습관에 관련된 당뇨병(ADA 공복혈당기준) 및 공복혈당장애의 유병률- 1998년 국민건강영양조사에 의한 -", Diabetes and Metabolism Journal, 29(2), pp.151~166 (2005), 대한당뇨병학회
- Chen LK, "Metabolic characteristics and insulin resistance of impaired fasting glucose among the middle-aged and elderly Taiwanese", Diabetes Res Clinic Pract, 71(2), pp.170~176 (2006)
- Hung WW, "Metabolic risk factors in southern Taiwanese with impaired fasting glucose of 100 to 109 mg", dL, 2007, pp.56(4), 528~532
- Attvall S, "Smoking induces insulin resistance: A potential link with the insulin resistance syndrome", J Intern Med, 233(4), pp.327~332 (1993)
- 박창해, "우리나라 성인 남성에서 흡연량과 공복혈당장애 또는 제2형 당뇨병 발생과의 연관성", 예방의학회지, 41(4), pp.249~254 (2008), 대한예방의학회
- 엄홍대, "규칙적 운동과 제 2형 당뇨병 발생에 관한 전향적 코호트 연구- 공복혈당장애군을 대상으로-", 예방의학회지, 41(1), pp.45~50 (2008), 대한예방의학회
- Pradhan AD, "reactive protein, interleukin-6, and risk of developing type 2 diabetes mellitus", JAMA, 286(3), pp.327~334 (2001)
- Howard BV, "C-Reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: Insights from the Genetics of Coronary Artery Disease in Alaska Natives (GCADAN) study", Diabetes Care, 31(12), pp.2312~2314 (2008)
- 김영춘, "한국인 성인에서 혈당 및 혈압 정도에 따른 인슐린저항성 및 혈중 hsCRP 농도의 비교", 대한내과학회지, 68(2), pp.178~185 (2005), 대한내과학회
- Lim JS, "Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?", Free Radic Biol Med, 37(7), pp.1018~1023 (2004)
- Choi KM, "Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly Koreans", Clin Endocrinol, 41(1), pp.75~80 (2004)
- Snehalatha C, "Plasma adiponectin is an independent predictor of type 2 diabetes in Asian indians", Diabetes Care, 26(12), pp.3226~32229 (2003)
- Stefan N, "Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans", Diabetes, 51(6), pp.1884~1888 (2002)
- Kelly DE, "Fuel selection in human skeletal muscle in insulin resistance: a reexamination", Diabetes, 49(5), pp.677~683 (2000)
- Jellinger PS, "Metabolic consequences of hyperglycemia and insulin resistance", Clin Cornerstone, 8(7), pp.S30~S42 (2007)
- 이시훈, "대사증후군의 위험예측인자로서 인슐린저항성", 대한내과학회지, 63(1), pp.7~60 (2002), 대한내과학회