본문 바로가기
KERD
논문KCI 등재

우울장애의 신경생물학적 최신 지견 : 세로토닌 전달체에 대한 영상 유전학적 연구를 중심으로

Current Understanding in Neurobiology of Depressive Disorders : Imaging Genetic Studies on Serotonin Transporter

2

조회

0

다운로드

2

인용

0

참고문헌

주제분류정신과학

초록

Depressive disorders have strong genetic components. However, conventional linkage and association studies have not yielded definitive results. These might be due to the absence of objective diagnostic tests, the complex nature of human behavior or the incomplete penetrance of psychiatric traits. Imaging genetics explores the influences of genetic variation on the brain function or structure. This technique could provide a more sensitive assessment than traditional behavioral measures in psychiatric studies. Imaging genetics is a relatively new field of psychiatric researches, and may improve our understanding on neurobiology of psychiatric disorders. In this review, current understanding in neurobiology of depressive disorders, especially imaging genetic studies on serotonin transporter will be discussed.

Abstract

Depressive disorders have strong genetic components. However, conventional linkage and association studies have not yielded definitive results. These might be due to the absence of objective diagnostic tests, the complex nature of human behavior or the incomplete penetrance of psychiatric traits. Imaging genetics explores the influences of genetic variation on the brain function or structure. This technique could provide a more sensitive assessment than traditional behavioral measures in psychiatric studies. Imaging genetics is a relatively new field of psychiatric researches, and may improve our understanding on neurobiology of psychiatric disorders. In this review, current understanding in neurobiology of depressive disorders, especially imaging genetic studies on serotonin transporter will be discussed.

참고문헌 (37)

  1. Kessler RC, "The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)", JAMA, 289, pp.3095~3105 (2003)
  2. Korea National Statistical Office, "2008 Annual report on the cause of death statistics" (2009), Korea National Statistical Office
  3. Kendler KS, "Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes", Psychol Med, 31, pp.605~616 (2001)
  4. 김용구, "우울증과 유전자-환경 상호작용", 신경정신의학, 49(6), pp.538~545 (2010), 대한신경정신의학회
  5. Kempf L, "Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function", PLoS Genet, 4, pp.e1000252~ (2008)
  6. Scharinger C, "The genetic blueprint of major depressive disorder: Contributions of imaging genetics studies", World J Biol Psychiatry, 12, pp.474~488 (2011)
  7. Plomin R, "The genetic basis of complex human behaviors", Science, 264, pp.1733~1739 (1994)
  8. Mattay VS, "Imaging genetic influences in human brain function", Curr Opin Neurobiol, 14, pp.239~247 (2004)
  9. Berger M, "The expanded biology of serotonin", Annu Rev Med, 60, pp.355~366 (2009)
  10. Wrase J, "Serotonergic dysfunction: brain imaging and behavioral correlates", Cogn Affect Behav Neurosci, 6, pp.53~61 (2006)
  11. Lesch KP, "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region", Science, 274, pp.1527~1531 (1996)
  12. Caspi A, "Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene", Science, 301, pp.386~389 (2003)
  13. Heils A, "Allelic variation of human serotonin transporter gene expression", J Neurochem, 66, pp.2621~2624 (1996)
  14. Kim DK, "Serotonin transporter gene polymorphism and antidepressant response", Neuroreport, 11, pp.215~219 (2000)
  15. Ham BJ, "Serotonergic genes and personality traits in the Korean population", NEUROSCI LETT, 354, pp.2~5 (2004)
  16. Mayberg HS, "Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment", Br Med Bull, 65, pp.193~207 (2003)
  17. Amunts K, "Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps", Anat Embryol, 210, pp.343~352 (2005)
  18. Hamilton JP, "Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies", Mol Psychiatry, 13, pp.993~1000 (2008)
  19. 김유라, "기분장애 뇌신경기저에 대한 이해:뇌영상 연구를 중심으로", 생물정신의학, 18(1), pp.15~24 (2011), 대한생물정신의학회
  20. Woon FL, "Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.1181~1188 (2010)
  21. Nestler EJ, "Neurobiology of depression", Neuron, 34, pp.13~25 (2002)
  22. Lorenzetti V, "Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies", J Affect Disord, 117, pp.1~17 (2009)
  23. McKinnon MC, "A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder", J Psychiatry Neurosci, 34, pp.41~54 (2009)
  24. Stevens FL, "Anterior cingulate cortex: unique role in cognition and emotion", J Neuropsychiatry Clin Neurosci, 23, pp.121~125 (2011)
  25. Koolschijn PC, "Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies", Hum Brain Mapp, 30, pp.3719~3735 (2009)
  26. Tanti A, "Open questions in current models of antidepressant action", Br J Pharmacol, 159, pp.1187~1200 (2010)
  27. Semendeferi K, "Humans and great apes share a large frontal cortex", Nat Neurosci, 5, pp.272~276 (2002)
  28. Kringelbach ML, "The human orbitofrontal cortex: linking reward to hedonic experience", Nat Rev Neurosci, 6, pp.691~702 (2005)
  29. aan het Rot M, "Neurobiological mechanisms in major depressive disorder", CMAJ, 180, pp.305~313 (2009)
  30. Phillips ML, "Neurobiology of emotion perception II: Implications for major psychiatric disorders", Biol Psychiatry, 54, pp.515~528 (2003)
  31. Hariri AR, "Serotonin transporter genetic variation and the response of the human amygdala", Science, 297, pp.400~403 (2002)
  32. Hariri AR, "Genetics of emotional regulation: the role of the serotonin transporter in neural function", Trends Cogn Sci, 10, pp.182~191 (2006)
  33. Frodl T, "Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression", Arch Gen Psychiatry, 61, pp.177~183 (2004)
  34. Frodl T, "Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression", Am J Med Genet B Neuropsychiatr Genet, 147B, pp.1003~1007 (2008)
  35. Eker MC, "Smaller hippocampus volume is associated with short variant of 5-HTTLPR polymorphism in medication-free major depressive disorder patients", Neuropsychobiology, 63, pp.22~28 (2011)
  36. Pezawas L, "5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression", Nat Neurosci, 8, pp.828~834 (2005)
  37. 함병주, "Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women", GENES BRAIN AND BEHAVIOR, 7, pp.899~905, BLACKWELL PUBLISHING

관련 논문AI추천

이 간행물의 다른 논문 (13건)