Methylphenidate 투약에 따른 주의력결핍 광잉운동장애 아동의 정량화 뇌파의 변화
Altered Quantified EEG Activity Following Adminisstration of Methylphenidate in Children with Attention Deficit Hyperactivity Disorder
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초록
저자들은 ADHD 환아들이 보이는 증가된 서파 활동(주로 전두엽 영역의 쉐타파)과 감소된 후두엽 영역의 베타파 활동이 각각 피질의 지연된 성숙(delayed maturation)과 각성 감소(hypoarousal)를 반영한다는 사실을 기초로 해서, MPH가 ADHD 아동에 미치는 신경생리학적 영향을 알아보기 위해서 2001년 1월 3일부터 2001년 7월 28일까지 경북대학교 병원 정신과 외래와 백 정신과의원을 방문한 환아중 ADHD로 진단받은 남아 14명과 여아1명등 15명의 환아들을 연구대상으로 하여 MPH를 주기 전과 MPH 투약 1시간후의 정량화 뇌파 소견을 비교하여 다음과 같은 결과를 얻었다.
Abstract
Objectives: Quantified Electroencephalography(QEEG) has been widely used to examine the electrophysiological disturbance in Attention Deficit Hyperactivity Disorder(ADHD), particularly with respect to increased slow wave activity and reduced fast wave activity. On the basis of these aspects, this study was designed to evaluate the effects of Methylphenidate(MPH) on QEEG in ADHD children by comparison of QEEG before and 1 hour after administration of MPH. Methods: The subjects that entered this study were 15 children (14 boys and 1 girls) who were diagnosed as ADHD by DSM-IV at department of psychiatry of Kyunpook National University Hospital and Baek's psychiatry clinic. We examined the Quantified Electroencephalography(QEEG) activity 1 hour after administration of MPH and compared these results with those of QEEG activity before administration of MPH. Results: 1) In central(T4) and posterior(Cp1, Cp2, P3, Po1, Po2, O1, Oz, O2) area, they showed statistically significant decreased absolute delta1(δ1) activity(P<0.05) 1 hour after administration of MPH, compared to the results before administration of MPH. 2) In central(C4) area, they showed statistically significant decreased absolute delta2(δ2) activity(P<0.05) 1 hour after administration of MPH, compared to the results before administration of MPH. 3) In anterior(F3) area, they showed statistically significant decreased absolute beta(β)2 activity 1 hour after administration of MPH, compared to the results before administration of MPH. Conclusion: The results in this study predict partly the hypothesis that Methylphenidate can manifest its effect on their symptoms by reversing increased slow wave activity and reduced fast wave activity in ADHD children.