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알코올리즘 가족력이 있는 한국인 사회적 음주자에서 심리적 스트레스가 타액 코티졸 농도에 미치는 영향

Salivary Cortisol Responses to Psychological Stress in Korean Social Drinkers with a Family History of Alcoholism

김수연|김지훈|김대욱|김성곤|민은정|김진미|변원탄|서유나|박문일
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2012.10|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제18권 제2호|pp. 155-163

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참고문헌

키워드

스트레스StressAlcoholism타액 코티졸Salivary cortisol가족력Family history알코올리즘
주제분류정신과학

초록

Objectives：A number of studies have shown dysregulation of the hypothalamus-pituitary-adrenal axis in alcoholics. The aim of the present study was to determine whether there are differences in salivary cortisol responses to a psychological stressor between nonalcoholic offspring from families with a history of alcoholism and those without a family history of alcoholism in Korea. Methods：We studied 45 healthy social drinkers, who were medical students aged≥18 years. The participants completed a baseline assessment and, salivary cortisol levels were obtained. All subjects were exposed to almost 15 minutes of stress. Immediately following completion of the stress exposure, four additional salivary specimens were obtained for cortisol levels at 15 minute intervals. The subjects were divided into two groups those who reported a history of alcoholism in either parent(FHP, n=9) and those who reported no alcoholism in their family for three generations(FHN, n=30). Results：A significant difference in salivary cortisol by family history group(p＜.001), and by time was discovered (p=.005) with a repeated-measures ANOVA. Basal salivary cortisol levels in FHP subjects were significantly higher than those in FHN subjects(p=.003). After stress exposure, salivary cortisol levels decreased significantly over time in the FHN group, whereas they did not in the FHP group. Conclusion：FHP subjects had higher baseline salivary cortisol concentrations than those of FHN subjects and maintained the levels after stress. This finding suggests that social drinkers with a history of alcoholism in a parent have increased vulnerability to stress and difficulty coping with stress effectively.

Abstract

Objectives：A number of studies have shown dysregulation of the hypothalamus-pituitary-adrenal axis in alcoholics. The aim of the present study was to determine whether there are differences in salivary cortisol responses to a psychological stressor between nonalcoholic offspring from families with a history of alcoholism and those without a family history of alcoholism in Korea. Methods：We studied 45 healthy social drinkers, who were medical students aged≥18 years. The participants completed a baseline assessment and, salivary cortisol levels were obtained. All subjects were exposed to almost 15 minutes of stress. Immediately following completion of the stress exposure, four additional salivary specimens were obtained for cortisol levels at 15 minute intervals. The subjects were divided into two groups those who reported a history of alcoholism in either parent(FHP, n=9) and those who reported no alcoholism in their family for three generations(FHN, n=30). Results：A significant difference in salivary cortisol by family history group(p＜.001), and by time was discovered (p=.005) with a repeated-measures ANOVA. Basal salivary cortisol levels in FHP subjects were significantly higher than those in FHN subjects(p=.003). After stress exposure, salivary cortisol levels decreased significantly over time in the FHN group, whereas they did not in the FHP group. Conclusion：FHP subjects had higher baseline salivary cortisol concentrations than those of FHN subjects and maintained the levels after stress. This finding suggests that social drinkers with a history of alcoholism in a parent have increased vulnerability to stress and difficulty coping with stress effectively.

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