조기발병 경도인지장애에서 해마 부분체의 구조적 변화
Structural Changes in the Hippocampal Subfields in Early-Onset Mild Cognitive Impairment
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Objectives:The aim of this study was to examine the structural change in the hippocampal subfields in early-onset (EO) mild cognitive impairment (MCI) patients associated with the APOE ε4 carrier state. Methods:This study had 50 subjects aged 55-63 years, all of whom were diagnosed with amnestic MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The volumes of hippocampal subfields were measured for all the subjects. The calculations were based on the change of the volumes between the 2-year-interval brain Magnetic resonance image (MRI) scans between MCIcont and ADconv groups according to the Apolipoprotein ε4 (APOE ε4) carrier state. Results:There was a significant correlation between APOE ε4 allele and structural changes in several hippocampal subfields. The volume reduction in cornus ammonis 1 (CA1) field and subiculum, especially in the APOE ε4 carriers. The significance was more prominent in ADconv group. Conclusion:These results suggest that the possession of APOE ε4 allele may lead to significantly greater predilection for the structural changes in hippocampal subfields, showing significant changes, especially in the ADconv patients compared with MCIcont patients.
Abstract
Objectives:The aim of this study was to examine the structural change in the hippocampal subfields in early-onset (EO) mild cognitive impairment (MCI) patients associated with the APOE ε4 carrier state. Methods:This study had 50 subjects aged 55-63 years, all of whom were diagnosed with amnestic MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The volumes of hippocampal subfields were measured for all the subjects. The calculations were based on the change of the volumes between the 2-year-interval brain Magnetic resonance image (MRI) scans between MCIcont and ADconv groups according to the Apolipoprotein ε4 (APOE ε4) carrier state. Results:There was a significant correlation between APOE ε4 allele and structural changes in several hippocampal subfields. The volume reduction in cornus ammonis 1 (CA1) field and subiculum, especially in the APOE ε4 carriers. The significance was more prominent in ADconv group. Conclusion:These results suggest that the possession of APOE ε4 allele may lead to significantly greater predilection for the structural changes in hippocampal subfields, showing significant changes, especially in the ADconv patients compared with MCIcont patients.
참고문헌 (35)
- Pericak-Vance MA, "Identification of novel genes in late-onset Alzheimer’s disease", Exp Gerontol, 35, pp.1343~1352 (2000)
- Ertekin-Taner N, "Genetics of Alzheimer disease in the pre-and post-GWAS era", Alzheimers Res Ther, 2, pp.3~ (2010)
- Rossor MN, "The diagnosis of young-onset dementia", Lancet Neurol, 9, pp.793~806 (2010)
- Ye BS, "Neuropsychological performance and conversion to Alzheimer’s disease in early-compared to late-onset amnestic mild cognitive impairment : CREDOS study", Dement Geriatr Cogn Disord, 34, pp.156~166 (2012)
- Manning EN, "APOE epsilon4 is associated with disproportionate progressive hippocampal atrophy in AD", PLoS One, 9, pp.e97608~ (2014)
- Chiang GC, "Impact of apolipoprotein E4-cerebrospinal fluid beta-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment", Alzheimers Dement, 7, pp.514~520 (2011)
- Cohen RM, "Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women", Neurology, 57, pp.2223~2228 (2001)
- Crivello F, "Effects of ApoE-epsilon4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons", Neuroimage, 53, pp.1064~1069 (2010)
- Moffat SD, "Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype", Neurology, 55, pp.134~136 (2000)
- Morra JH, "Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer’s disease, mild cognitive impairment, and elderly controls", Neuroimage, 45, pp.S3~15 (2009)
- Mueller SG, "Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer’s disease using high resolution MRI at 4 T", Neuroimage, 42, pp.42~48 (2008)
- de Flores R, "Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease", Neuroscience, 309, pp.29~50 (2015)
- Csernansky JG, "Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus. Dementia of the Alzheimer type", Neurology, 55, pp.1636~1643 (2000)
- Chetelat G, "Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxelbased morphometry", Neuropsychologia, 46, pp.1721~1731 (2008)
- Dinov I, "Neuroimaging study designs, computational analyses and data provenance using the LONI pipeline", PLoS One, 5, pp.e13070~ (2010)
- Rao AT, "Genetics of Alzheimer disease", AJNR Am J Neuroradiol, 35, pp.457~458 (2014)
- Corder EH, "Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families", Science, 261, pp.921~923 (1993)
- Jaekwang Kim, "Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms", Molecules and Cells, 37(11), pp.767~776 (2014), 한국분자세포생물학회
- Thal DR, "Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia", Exp Neurol, 163, pp.98~110 (2000)
- Braak E, "Alzheimer’s disease : transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon’s horn", Acta Neuropathol, 93, pp.323~325 (1997)
- Braak H, "Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry", Acta Neuropathol, 112, pp.389~404 (2006)
- Adler DH, "Characterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histology", Proc Natl Acad Sci U S A, 115, pp.4252~4257 (2018)
- Shi F, "Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer’s disease : Meta-analyses of MRI studies", Hippocampus, 19, pp.1055~1064 (2009)
- Apostolova LG, "Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps", Arch Neurol, 63, pp.693~699 (2006)
- Apostolova LG, "3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI", Hum Brain Mapp, 31, pp.786~797 (2010)
- Leung KK, "Cerebral atrophy in mild cognitive impairment and Alzheimer disease : rates and acceleration", Neurology, 80, pp.648~654 (2013)
- Nadal L, "Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer’s clinical syndrome", Neurobiol Aging, 90, pp.75~83 (2020)
- Fjell AM, "Alzheimer’s Disease Neuroimaging I. What is normal in normal aging? Effects of aging, amyloid and Alzheimer’s disease on the cerebral cortex and the hippocampus", Prog Neurobiol, 117, pp.20~40 (2014)
- Hanko V, "In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies", Neurobiol Aging, 74, pp.171~181 (2019)
- Frisoni GB, "In vivo neuropathology of the hippocampal formation in AD : a radial mapping MR-based study", Neuroimage, 32, pp.104~110 (2006)
- Frisoni GB, "Mapping local hippocampal changes in Alzheimer’s disease and normal ageing with MRI at 3 Tesla", Brain, 131, pp.3266~3276 (2008)
- Li YD, "Discriminative analysis of mild Alzheimer’s disease and normal aging using volume of hippocampal subfields and hippocampal mean diffusivity : an in vivo magnetic resonance imaging study", Am J Alzheimers Dis Other Demen, 28, pp.627~633 (2013)
- Mueller SG, "Selective effect of age, Apo e4, and Alzheimer’s disease on hippocampal subfields", Hippocampus, 19, pp.558~564 (2009)
- Lindberg O, "Hippocampal shape analysis in Alzheimer’s disease and frontotemporal lobar degeneration subtypes", J Alzheimers Dis, 30, pp.355~365 (2012)
- Trujillo-Estrada L, "Early neuronal loss and axonal", presynaptic damage is associated with accelerated amyloid-beta accumulation in AbetaPP, J Alzheimers Dis, pp.2014, 42[DOI]
